1968
DOI: 10.1002/cpt196892240
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Effects of chronic administration of the amphetamines and other stimulants on behavior

Abstract: Effects of chronic administration of the amphetamines and other stimulants on behaviorAfter a brief survey of effects in man, the authors review behavioral studies in animals on the effects of chronic administration of dl-amphetamine, d-amphetamine, methamphetamine, cocaine, pipradrol, methylphenidate, phenmetrazine, and

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Cited by 108 publications
(18 citation statements)
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“…It should be pointed out that oscil lated groups exhibited shivering-like movements right after exercise, a phenomenon similar to that seen in motionsickness, yet distinguishable from shivering, a rhythmic contraction of voluntary muscle (9 …”
Section: Discussionmentioning
confidence: 65%
“…It should be pointed out that oscil lated groups exhibited shivering-like movements right after exercise, a phenomenon similar to that seen in motionsickness, yet distinguishable from shivering, a rhythmic contraction of voluntary muscle (9 …”
Section: Discussionmentioning
confidence: 65%
“…When taken at relatively lower doses, amphetamines cause mood enhancement, such as experiences of euphoria, increased alertness, a sense of self-confidence, and suppression of fatigue [10]. Development of tolerance to mood enhancement increases the intake frequency and dose of the drug in AMPH abusers [11]. Repeated drug use causes dysregulation of the brain reward system that progressively increases compulsive and uncontrolled drug intake [6,12,13].…”
Section: Introductionmentioning
confidence: 99%
“…In mature animals, chronic amphetamine-like drugs exert a profound effect on the monoamine system of the brain. These changes appear as deficits in neurochemical function (e.g., neurotransmitter uptake, transmitter metabolism, and receptor changes; Caldecott-Hazard et al, 1989a;Ellinwood and Lee, 1983;Ramirez et al, 1983;Robinson and Becker, 1986;Tonge, 1974), changes in behavior (Caldecott-Hazard et al, 1989b;Cassens et al, 1981;Kosman and Unna, 1968;Robinson and Becker, 1986;Tonge, 1974), and morphological degeneration of neurons (Ellison et al, 1978;Ricaurte et al, 1984;Wahnschaffe and Esslen, 1985). Many of these changes are probably related to the neurotoxicity of these drugs.…”
Section: Introductionmentioning
confidence: 99%