In utero methamphetamine effects: I. Behavior and monoamine uptake sites in adult offspring

Weissman, Arthur D.; Caldecott-Hazard, S

doi:10.1002/syn.890130307

Cited by 33 publications

(24 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the present study demonstrates that pups prenatally exposed to M opened their eyes later than controls or saline-exposed pups. This finding is in agreement with the work of Cho, Lyu, Lee, Kim, and Chin (1991) and Martin (1975), while it is in contrast with the data of Weissman and Caldecott-Hazard (1993). Further, Vorhees (1985) showed that the .5 mg/kg amphetamine group showed delayed eye opening, but the 2.0 mg/kg group did not.…”

Section: Discussionsupporting

confidence: 43%

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Hrubá

Schutová

Šlamberová

et al. 2008

Developmental Psychobiology

View full text Add to dashboard Cite

The present study tested the hypothesis that cross-fostering influences the development of rat pups. Mothers were exposed daily to injection of methamphetamine (M) (5 mg/kg) or saline for 9 weeks: 3 weeks prior to impregnation, throughout gestation and lactation periods. Control females animals without any injections were used. On postnatal day (PD) 1, pups were cross-fostered so that each mother received four pups of her own and eight pups from the mothers with the other two treatments. Offspring were tested for sensorimotor development in preweaning period by using tests of: negative geotaxis, tail pull, righting reflexes, rotarod and bar-holding. Further, the pups were weighed daily. Our results showed that birth weight in prenatally M-exposed pups was lower than in control or saline-exposed pups. Prenatally M-exposed pups gained less weight than control or saline-exposed pups regardless of postnatal treatment and sex. Further, our data demonstrated that prenatal and postnatal M exposure impairs sensorimotor functions in most of the tests. On the other hand, the negative effect of prenatal M exposure was partially suppressed in prenatally M-exposed pups by cross-fostering to control dams. Our hypothesis that cross-fostering may affect postnatal development of pups was confirmed.

show abstract

Section: Discussionsupporting

confidence: 43%

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Hrubá

Schutová

Šlamberová

et al. 2008

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…MA exposure during brain development affects multiple neurotransmitter systems, including the dopamine and serotonin systems (Won et al , 1992, 2002; Weissman and Caldecott-Hazard 1993; Heller et al , 2001a,b; Crawford et al , 2003; Schaefer et al , 2007). Although less well known, MA also affects the brain acetylcholine (ACh) system.…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Siegel¹,

Craytor²,

Raber³

2010

Behavioural Pharmacology

View full text Add to dashboard Cite

Exposure to methamphetamine during brain development impairs cognition in humans and rodents. In mice, these impairments are greater in females than males. Genetic factors, such as apolipoprotein E genotype, may modulate the cognitive effects of methamphetamine. Methamphetamine-induced alterations in the brain acetylcholine system may contribute to the cognitive effects of methamphetamine and may also be modulated by apolipoprotein E isoform. We assessed the long-term effects of methamphetamine exposure during brain development on cognitive function and muscarinic acetylcholine receptors in mice, and whether apolipoprotein E isoform modulates these effects. Mice expressing human apolipoprotein E3 or E4 were exposed to methamphetamine (5 mg/kg) or saline once a day from postnatal day 11-20 and behaviorally tested in adulthood. Muscarinic acetylcholine receptor binding was measured in the hippocampus and cortex. Methamphetamine exposure impaired novel location recognition in female, but not male, mice. Methamphetamine-exposed male and female mice showed impaired novel object recognition and increased number of muscarinic acetylcholine receptors in the hippocampus. The cognitive and cholinergic effects of methamphetamine were similar in apolipoprotein E3 and E4 mice. Thus, the cholinergic system, but not apolipoprotein E isoform, might play an important role in the long-term methamphetamine-induced cognitive deficits in adulthood.

show abstract

“…This psychostimulant with well-documented neurotoxic effects on mature monamine neurons [22,23] accumulates in the placenta in high concentrations [24]. According to rodent models, most of its teratogenic effects also involve disruptions of monoamine systems, including synaptic remodeling of axonal terminals [25] and disruptions in monoamine transmitter levels, in particular frontal [26] and striatal [27,28,29] dopamine depletion.…”

Section: Introductionmentioning

confidence: 99%

Frontostriatal Connectivity in Children during Working Memory and the Effects of Prenatal Methamphetamine, Alcohol, and Polydrug Exposure

et al. 2012

View full text Add to dashboard Cite

Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and polydrug exposure. Because the putamen is part of the corticostriatal motor loop whereas the caudate is involved in the executive loop, we hypothesized that a loss of segregation between distinct corticostriatal networks may occur in these participants. The current study was designed to test this hypothesis using functional connectivity MRI. We examined 50 children ranging in age from 7 to 15, including 19 with prenatal methamphetamine exposure (15 of whom had concomitant prenatal alcohol exposure), 13 with prenatal exposure to alcohol but not methamphetamine, and 18 unexposed controls. We measured the coupling between blood oxygenation level dependent (BOLD) fluctuations during a working-memory task in four striatal seed regions and those in the rest of the brain. We found that the putamen seeds showed increased connectivity with frontal brain regions involved in executive functions while the caudate seeds showed decreased connectivity with some of these regions in both groups of exposed subjects compared to controls. These findings suggest that localized brain abnormalities resulting from prenatal exposure to alcohol and/or methamphetamine lead to a partial rewiring of corticostriatal networks. These results represent important progress in the field, and could have substantial clinical significance in helping devise more targeted treatments and remediation strategies designed to better serve the needs of this population.

show abstract

In utero methamphetamine effects: I. Behavior and monoamine uptake sites in adult offspring

Cited by 33 publications

References 52 publications

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Long-term effects of methamphetamine exposure on cognitive function and muscarinic acetylcholine receptor levels in mice

Frontostriatal Connectivity in Children during Working Memory and the Effects of Prenatal Methamphetamine, Alcohol, and Polydrug Exposure

Contact Info

Product

Resources

About