Effects of chrysin on free radicals and enzymatic antioxidants in N<sup>ω</sup>-nitro-l-arginine methyl ester: Induced hypertensive rats

Ramanathan, Veerappan

doi:10.4103/2231-0738.129600

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…However, a significant increase was recorded in GSH level in the L-NAME group treated with n-hexane fraction of PB. The effect of L-NAME on MDA and antioxidant enzymes levels recorded in this study is in contrast with previous studies, where it was reported that L-NAME caused an increase in MDA level and a decrease in antioxidant enzymes activities [42,43]. However, a study reported no significant change in MDA and some antioxidant enzymes level in L-NAME treated rats [36].…”

Section: Discussioncontrasting

confidence: 99%

Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats

et al. 2020

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Purpose The reduction in nitric oxide (NO) bioavailability accelerates atherosclerosis development, augments lipolysis, elevates blood pressure and upregulate leukocyte level. This study was designed to examine the biochemical constituents of fractions of Peristrophe bivalvis (PB) leaf, their effect on blood pressure, serum lipid contents and complete blood count in NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats. Method Male Wistar rats were grouped into control and hypertensive groups. The hypertensive group was pretreated with 60 mg/kg b.w of L-NAME (L-NAME60) daily for two weeks. They were then randomly sub-grouped into: Hypertensive (H), Hypertensive+n-hexane fraction (HHF), Hypertensive+dichloromethane fraction (HDF), Hypertensive+ethyl acetate fraction (HEF) and Hypertensive+aqueous fraction (HAF) groups. These were orally gavaged with L-NAME60 and L-NAME60+200 mg/kg b.w of fractions of PB respectively, daily for two weeks. Result The biochemical components analysis of the fractions of PB identified numerous polar and non polar compounds like alkaloids, organic acids and esters. The results showed a significant increase in NO level in HHF and HEF groups compared to H. Total cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C) and very LDL-C were significantly decreased in HAF group compared to H. High density lipoprotein cholesterol (HDL-C) increased significantly and atherogenic indices decreased significantly in HHF, HDF and HAF groups compared to H, while reduced glutathione level increased significantly in HHF group compared to H. White blood cells count effectively decreased in HEF group compared to H. Conclusion In brief, the fractions of PB leaf increased HDL-C and NO, and decrease atherogenic indices in L-NAME treated rats.

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Section: Discussioncontrasting

confidence: 99%

Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats

et al. 2020

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“…CR is also a highly abundant substance in propolis (28 g/L) (Mani & Natesan, 2018). Malarvili and Veerappan (2014) reported that CR inhibited xanthine oxidase and MDA. In our study, CR can also reduce the formation of free radicals by inhibiting of xanthine oxidase.…”

Section: Ta B L Ementioning

confidence: 99%

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

et al. 2020

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Chrysin (CR) is a flavone found in propolis and many plants. Lipopolysaccharide (LPS) is a component of the cell wall of gram‐negative bacteria that causes sepsis. The purpose of this study was to investigate the effects of CR on LPS‐induced sepsis in rats. LPS intraperitoneal and a single dose and CR were given orally for 10 days. Rats were sacrificed, blood samples were taken, liver, lung, and kidney tissues were dissected, homogenized, and histopathological analysis was carried out. When CR groups compared to sepsis group, CR significantly decreased the serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT), interleukin‐1 beta (IL‐1β), interleukin‐10 (IL‐10), tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), and levels of malondialdehyde (MDA) in tissues. CR also increased the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) in tissues. Histopathological findings were consistent with biochemical findings. Conclusion, CR could reduce the oxidative stress markers and cytokines in sepsis. Practical applications Our approach is to determine the antioxidant and anti‐inflammatory effects of chrysin, known as a flavolonoid, which are found in many plants and foods such as honey and propolis. In this study, experimental sepsis model was created using LPS. According to the results of the study, CR can attribute to the ameliorating of oxidative damage in tissues (lung, liver, and kidney) and it can suppress the sepsis‐associated acute tissue injury via reduction of inflammation in rats. Even, CR can be used as a pharmacological agent in inflammatory diseases caused by other sources and in many cases causing oxidation.

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“…Chrysin (5,7-dihydroxy flavones structure shown in Figure 1) is a naturally occurring flavone contained in flowers such as the blue passion flower (Passiflora caerulea) and the Indian trumpet flower, as well as in edible items such as mushroom, [8] honey and propolis. [9] Chrysin has been found to possess antioxidant, [10] anti-allergic, [11] anti-inflammatory, [12] anti-cancer, [13] antiestrogenic, [14] anxiolytic [15] and antihypertensive [16] properties.…”

Section: Introductionmentioning

confidence: 99%

Chrysin enhances antioxidants and oxidative stress in L-NAME-induced hypertensive rats

Ramanathan¹,

Rajagopal

2015

Int J Nutr Pharmacol Neurol Dis

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Objectives:The study seeks to evaluate the effect of chrysin; a natural, biologically active compound extracted from plants, honey or propolis, on the tissues and circulatory antioxidant status and lipid peroxidation in N ω -nitro-l-arginine methyl ester (L-NAME) induced hypertensive rats. Materials and Methods: Male albino rats were divided into four groups. Control (Group I) and chrysin supplementation of the control (Group II) received normal diet. Groups III and IV received L-NAME (40 mg/kg B.W). Groups II and IV received chrysin (25 mg/kg B.W) dissolved in 0.2% dimethylsulfoxide solution after the 4 th week. Results and Discussion: The results showed significantly elevated levels of tissue and circulatory thiobarbituric acid reactive substances, conjugated dienes and lipid hydroperoxides, and significantly lowered enzymic and non-enzymic antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, vitamin C and vitamin E in L-NAME-induced hypertensive rats compared with those in control group. From chrysin administration to rats with L-NAME-induced hypertension leads to tissue damage which significantly decreases the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes, and significantly elevates the activity of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, vitamin C and vitamin E in the tissues and circulation compared with those on the unsupplemented L-NAME induced hypertensive group. Conclusions: Chrysin offers protection against free radical-mediated oxidative stress in rats with L-NAME-induced hypertension.

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Effects of chrysin on free radicals and enzymatic antioxidants in N^ω-nitro-l-arginine methyl ester: Induced hypertensive rats

Cited by 13 publications

References 20 publications

Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats

Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

Chrysin enhances antioxidants and oxidative stress in L-NAME-induced hypertensive rats

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Effects of chrysin on free radicals and enzymatic antioxidants in Nω-nitro-l-arginine methyl ester: Induced hypertensive rats

Cited by 13 publications

References 20 publications

Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats

Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats

The effects of chrysin on lipopolysaccharide‐induced sepsis in rats

Chrysin enhances antioxidants and oxidative stress in L-NAME-induced hypertensive rats

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Product

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Effects of chrysin on free radicals and enzymatic antioxidants in N^ω-nitro-l-arginine methyl ester: Induced hypertensive rats