Effects of Cobalamin (Vitamin B12) on Gentamicin Induced Nephrotoxicity in Rat

Hajihashemi, Saeed; Hamidizad, Zeinab; Rahbari, Ali; Ghanbari, Fatemeh; Motealeghi, Zohre Aghaee

doi:10.1055/s-0043-117418

Cited by 18 publications

(29 citation statements)

References 41 publications

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“…As a result, serum level of MDA is elevated in diverse models of gentamicin-induced nephrotoxicity as showed by Hajihashemi et al study that established the protecting outcome of Zataria multiflora hydroalcoholic extract in the reduction of MDA with significant increasing effect of antioxidant enzyme activities [11].…”

Section: Discussionmentioning

confidence: 94%

Pomegranate Attenuates Acute Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats: The Potential Antioxidant and Anti-Inflammatory Effects

Al-Kuraishy

Al-Gareeb

Al-Naimi

2019

Asian J Pharm Clin Res

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Objectives: Nephrotoxicity is a renal-specific situation in which the excretion of toxic metabolites is reduced due to toxic agents and drugs. Gentamicin is an antibiotic belongs to aminoglycoside group which may induce nephrotoxicity due to induction of oxidative stress. Pomegranate is a component of the traditional medicine called Punica granatum with significant nephron-protective effect. Therefore, the objective of the present study was to evaluate the nephronprotective effect of pomegranate in gentamicin-induced nephrotoxicity. Methods: A total of 30 male Sprague-Dawley rats were used which divided into Group 1 (n=10): Rats treated with distilled water 5 ml/kg plus normal saline 5 ml/kg for 12 days, Group 2 (n=10): Rats treated with distilled water 5 ml/kg plus gentamicin 100 mg/kg for 12 days, and Group 3 (n=10): Rats treated with pomegranate 100 mg/kg plus gentamicin 100 mg/kg for 12 days. Blood urea, serum creatinine, malondialdehyde (MDA), kidney injury molecule (KIM-1), and cystatin-C were measured in both control and experimental groups. Results: Rats treated with gentamicin showed nephrotoxicity as evident by significant elevation in serum creatinine, blood urea, serum creatinine, KIM-1, MDA, and cystatin-C sera levels. Pomegranate leads to significant reduction of blood urea and serum creatinine compared to gentamicin group, p<0.05. Pomegranate also reduced MDA, KIM-1, and cystatin-C sera levels significantly compared to gentamicin group, p<0.01. Conclusion: Pomegranate produced significant nephroprotective effect on gentamicin-induced nephrotoxicity through modulation of oxidative stress and inflammatory biomarkers.

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Section: Discussionmentioning

confidence: 94%

Pomegranate Attenuates Acute Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats: The Potential Antioxidant and Anti-Inflammatory Effects

Al-Kuraishy

Al-Gareeb

Al-Naimi

2019

Asian J Pharm Clin Res

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“…The rats were anesthetized 24 h after reperfusion. Systolic blood pressure was measured using a Power Lab instrument (AD Instruments, Australia) [17,18] and employing the tail-cuff method. A longitudinal incision was then made on the surface of the abdo-men using a razor blade.…”

Section: Methodsmentioning

confidence: 99%

Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats

et al. 2019

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Background Ischemia-reperfusion (I-R) leads to acute kidney injury (AKI). The present study investigated the effects of nitroglycerine (NG) on improving renal dysfunctions caused by I-R in rats. Methodology Twenty-four rats were equally divided into four groups: (1) the control group, (2) the sham group, (3) the I-R group, and (4) NG-treated groups.NG (50 μg/kg) was injected intraperitoneally after induction of IR. I-R was induced through clamping of the bilateral renal artery and vein of both kidneys for 20 min followed by 24 h of reperfusion. Results NG significantly increased the creatinine clearance levels and renal blood flow rate (which was reduced by I-R). NG also significantly improved serum electrolytes (sodium and potassium) that were disordered by I-R. In addition, NG significantly offset impaired antioxidant defense mechanism and inhibited lipid peroxidation. Conclusions The results show NG has a protective effect on renal tissue against AKI caused by I-R. These protective effects mediated through antioxidant activity and decrease of lipid peroxidation.

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“…After 24 h of reperfusion, the rats' systolic blood pressure was measured from the tail by using a Power Lab instrument (AD Instruments, Australia) and the mean of systolic blood pressure was calculated for a rat. 13,14 The rats were anesthetized and a longitudinal cut was created in the abdomen with a blade. After separation of the artery and vein of the left kidney, after stabilization of amount of blood flow, the renal blood flow (RBF) was recorded for 30 min by using flow meter of Power Lab instrument (T402, America) 15,16 and the mean of blood flow was measured for 30 min.…”

Section: Methodsmentioning

confidence: 99%

“…After preparation the slides, tissue analysis was performed by an expert pathologist. 14,16 The changes in glomerular and tubular and vascular structure were analyzed. Glomerulus diameter and Bowman's space size, percentage of injuries in tubule and glomerulus, the number of red blood cells (RBCs) in glomeruli, the shedding of tubular cells, formation of cast proteins in the lumen, tubular cells necrosis and the formation of vacuoles within the cells were examined.…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat.

2019

J. contemp. med. sci.

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Objective Renal ischemia-reperfusion (I-R) induces acute kidney injury (AKI). In this study, the effect of hydralazine was investigated on the renal injury induced by the I-R in rats. Methods AKI was induced with bilateral obstruction of the renal artery and vein for 20 min following 24 h of reperfusion. Hydralazine (5mg/ kg) was injected intraperitoneally as post-treatment. Results Hydralazine significantly increased the levels of renal clearance of creatinine and renal blood flow, while they were decreased by I-R. Also, hydralazine significantly improved levels of serum electrolytes (sodium and potassium) that were impaired by I-R. The tissue malondialdehyde levels were significantly suppressed by hydralazine. Conclusion According to the results, the post-treatment of hydralazine had a therapeutic effect on renal I-R because of improved ion reabsorption and excretion and increased renal blood flow and glomerular filtration rate and decreased lipid peroxidation. Key words hydralazine, renal ischemia-reperfusion injury, rat This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

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Effects of Cobalamin (Vitamin B12) on Gentamicin Induced Nephrotoxicity in Rat

Cited by 18 publications

References 41 publications

Pomegranate Attenuates Acute Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats: The Potential Antioxidant and Anti-Inflammatory Effects

Pomegranate Attenuates Acute Gentamicin-Induced Nephrotoxicity in Sprague-Dawley Rats: The Potential Antioxidant and Anti-Inflammatory Effects

Effects of Nitroglycerine on Renal Ischemia-Reperfusion Injury in Adult Male Rats

Therapeutic Effects of Hydralazine on Renal Ischemia-Reperfusion Injury in Rat.

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