Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats

Han, Xiaolong; Xu, Yajun; Wang, Junbo; Pei, Xinrong; Yang, Ruiyue; Li, Ning; Li, Yong

doi:10.1016/j.bone.2008.12.005

Cited by 40 publications

(37 citation statements)

References 34 publications

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“…Previous studies showed that acupuncture can increase the serum E2 level, 7 and that E2 is associated with biochemical markers. 22 23 Therefore, we inferred that EA can similarly regulate biochemical markers by improving the serum E2 level.…”

Section: Discussionmentioning

confidence: 93%

Electroacupuncture Prevents Ovariectomy-Induced Osteoporosis in Rats: A Randomised Controlled Trial

et al. 2012

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Background Electroacupuncture (EA) treatment has been shown to increase bone mineral density (BMD) in ovariectomised (OVX) rats; however, the underlying mechanisms remain unclear. Objective To systematically evaluate the effects of EA on OVX rats and the Wnt/β-catenin signalling pathway. Methods Three-month-old female Sprague-Dawley rats were randomly divided into three different groups (n=10 each): sham operated control (sham operated), ovariectomy (OVX) and ovariectomy with EA treatment (OVX+EA). Rats in the OVX+EA group received 12-week EA treatments. Results Serum bone-specifi c alkaline phosphatase level (p<0.01), BMD of the proximal femoral metaphysis and the fi fth lumbar (L5) vertebral body (both, p<0.05) and maximum load and energy to failure of L5 vertebral body (both p<0.01) were signifi cantly higher in the OVX+EA group than in the OVX group. Trabecular area, trabecular width and trabecular number were signifi cantly higher in the OVX+EA group by 66.9%, 29.2% and 30.3%, respectively, than in the OVX group (all, p<0.01). Trabecular separation was 31.9% lower in the OVX+EA group than in the OVX group (p<0.01). Quantitative real-time reverse transcription polymerised chain reaction indicated that the expressions of mRNAs for low-density lipoprotein receptor-related protein 5 and β-catenin were signifi cantly increased in the OVX+EA group, as compared with the OVX group (p<0.01 and p<0.05, respectively). Conclusion This study demonstrates that EA can prevent OVX-induced bone loss and deterioration of bone architecture and strength by stimulating the Wnt/β-catenin signalling pathway. These fi ndings suggest that EA may bet a promising adjunct method for inhibiting OVX-induced osteoporosis in clinical settings.

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Section: Discussionmentioning

confidence: 93%

Electroacupuncture Prevents Ovariectomy-Induced Osteoporosis in Rats: A Randomised Controlled Trial

et al. 2012

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“…Cortical bones have been shown to be unaffected by estrogen deficiency. 45 This may explain why there are fewer differences between BMD and BMC. The different superscripts indicate significant differences (P < .05).…”

Section: Discussionmentioning

confidence: 99%

Whey Protein Concentrate Hydrolysate Prevents Bone Loss in Ovariectomized Rats

Kim

et al. 2015

Journal of Medicinal Food

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Milk is known as a safe food and contains easily absorbable minerals and proteins, including whey protein, which has demonstrated antiosteoporotic effects on ovariectomized rats. This study evaluated the antiosteoporotic effect of whey protein concentrate hydrolysate (WPCH) digested with fungal protease and whey protein concentrate (WPC). Two experiments were conducted to determine (1) efficacy of WPCH and WPC and (2) dose-dependent impact of WPCH in ovariectomized rats (10 weeks old). In Experiment I, ovariectomized rats (n = 45) were allotted into three dietary treatments of 10 g/kg diet of WPC, 10 g/kg diet of WPCH, and a control diet. In Experiment II, ovariectomized rats (n = 60) were fed four different diets (0, 10, 20, and 40 g/kg of WPCH). In both experiments, sham-operated rats (n = 15) were also fed a control diet containing the same amount of amino acids and minerals as dietary treatments. After 6 weeks, dietary WPCH prevented loss of bone, physical properties, mineral density, and mineral content, and improved breaking strength of femurs, with similar effect to WPC. The bone resorption enzyme activity (tartrate resistance acid phosphatase) in tibia epiphysis decreased in response to WPCH supplementation, while bone formation enzyme activity (alkaline phosphatase) was unaffected by ovariectomy and dietary treatment. Bone properties and strength increased as the dietary WPCH level increased (10 and 20 g/kg), but there was no difference between the 20 and 40 g/kg treatment. WPCH and WPC supplementation ameliorated bone loss induced by ovariectomy in rats.

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“…Guillerminet et al administered a fish and bovine-derived collagen hydrolysate enriched diet to ovariectomized mice for 12 weeks and observed that there was an increase in the osteoblast activity along with the reduction in differentiation and maturation of osteoclasts (Guillerminet et al, 2010). Studies have shown that cod bone gelatine may prevent bone loss by decreasing bone resorption in ovariectomized rats (Han et al, 2009). In osteoporosis patients, particularly in postmenopausal women, a collagen protein-rich diet may enhance and prolong the therapeutic effect of calcitonin (Adam et al, 1996;Cuneo et al, 2010).…”

Section: Marine Fishesmentioning

confidence: 99%

Marine Natural Products: New Avenue in Treatment of Osteoporosis

Chaugule¹,

Indap²,

Chiplunkar

2017

Front. Mar. Sci.

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Bone metabolism is a physiological process that maintains the skeletal integrity and bone functions. Skeletal integrity is always balanced by two key cell types-bone resorbing osteoclasts and bone-forming osteoblasts. Imbalance between generation and function of osteoclasts and osteoblasts often leads to pathological conditions such as osteoporosis, osteopetrosis, Paget's disease. Osteoporosis is one of the most common age-related diseases characterized by decreased bone mineral density and microarchitectural deterioration. Current therapies are indeed effective in preventing bone loss but are also followed by side effects. Since many years, marine organisms have been considered as a good source of bioactive molecules or compounds with potential pharmaceutical properties. Marine Natural Products (MNPs) derived from various marine resources such as marine cyanobacteria, dinoflagellates, algae, sponges, soft corals, molluscs, fishes, and mangroves had shown profound effect on bone metabolism through inhibiting osteoclastogenesis and up-regulating osteoblastogenesis via modulating RANK/RANKL/OPG pathway. Amongst the pre-clinically investigated MNPs for management of osteoporosis, very few are under phase I clinical trials. This review discusses the currently available pharmacological drugs and there major health concern in osteoporosis treatment. It further gives an insight into various marine resources and marine-derived bioactive products, depicting their mechanism of action, functional role, and how these can be exploited for the treatment of osteoporosis.

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Effects of cod bone gelatin on bone metabolism and bone microarchitecture in ovariectomized rats

Cited by 40 publications

References 34 publications

Electroacupuncture Prevents Ovariectomy-Induced Osteoporosis in Rats: A Randomised Controlled Trial

Electroacupuncture Prevents Ovariectomy-Induced Osteoporosis in Rats: A Randomised Controlled Trial

Whey Protein Concentrate Hydrolysate Prevents Bone Loss in Ovariectomized Rats

Marine Natural Products: New Avenue in Treatment of Osteoporosis

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