Effects of coenzyme Q10 on salivary secretion

Ryo, Koufuchi; Ito, Atsuko; Takatori, Rie; Tai, Yoshinori; Arikawa, Kazumune; Seido, Taro; Yamada, Takashi; Shinpo, Keiko; Tamaki, Yoh; Fukui, Kenji; Yamamoto, Yorihiro

doi:10.1016/j.clinbiochem.2011.03.029

Cited by 21 publications

(20 citation statements)

References 28 publications

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“…Recently, orally administered ubiquinol (CoQ10) 100 mg/day was shown to significantly improve salivary secretion (up to 80%) in dry mouth non-Parkinsonian patients [ 26 ].…”

Section: Xerostomiamentioning

confidence: 99%

Disorders of the Oral Cavity in Parkinson’s Disease and Parkinsonian Syndromes

Zlotnik

Balash²,

Korczyn

et al. 2015

Parkinson's Disease

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Awareness of nonmotor symptoms of Parkinson's disease is growing during the last decade. Among these, oral cavity disorders are, although prevalent, often neglected by the patients, their caregivers, and physicians. Some of these disorders include increased prevalence of caries and periodontal disease, sialorrhea and drooling, xerostomia, orofacial pain, bruxism, and taste impairment. Though many of these disorders are not fully understood yet and relatively few controlled trials have been published regarding their treatment, physicians should be aware of the body of evidence that does exist on these topics. This paper reviews current knowledge regarding the epidemiology, pathophysiology, and treatment options of disorders of the oral cavity in Parkinson's disease patients.

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“…Recently, orally administered ubiquinol (CoQ10) 100 mg/day was shown to significantly improve salivary secretion (up to 80%) in dry mouth non-Parkinsonian patients [ 26 ].…”

Section: Xerostomiamentioning

confidence: 99%

Disorders of the Oral Cavity in Parkinson’s Disease and Parkinsonian Syndromes

Zlotnik

Balash²,

Korczyn

et al. 2015

Parkinson's Disease

View full text Add to dashboard Cite

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“…Dormenval et al ( 5 ) reported that salivary flow rate was correlated with serum albumin concentrations and that the relative frequency of malnutrition was greater in subjects with lower salivary flow rates, as compared to those with higher levels of saliva secretion. Saito and coworkers reported that ingestion of astaxanthin, ( 6 ) coenzyme Q10, ( 7 ) isoflavones, ( 8 ) and quercetin ( 9 ) corrected impaired salivary secretion. Therefore, dietary modification or the use of a dietary supplement may prevent hyposalivation.…”

Section: Introductionmentioning

confidence: 99%

Changes in salivary flow rate following <i>Chlorella</i>-derived multicomponent supplementation

Otsuki

Shimizu

Zempo-Miyaki

et al. 2016

J. Clin. Biochem. Nutr.

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Decreases in saliva secretion compromise food mastication and swallowing, reduce mucosal immune function, and increase the risk for oral diseases like dental caries. Chlorella is a green alga that contains a variety of nutrients including amino acids, vitamins, and minerals. In our previous study, Chlorella-derived multicomponent supplementation did not affect salivary flow rates in healthy young individuals, but Chlorella-derived supplementation attenuated a decrease in saliva secretion that was observed during a kendo training camp. Hence, we hypothesized that Chlorella-derived supplementation increases saliva secretion in individuals with lower rates of saliva flow. Sixty-four subjects took Chlorella-derived tablets for four weeks. Before and after supplementation, saliva samples were collected by chewing cotton. In the complete study group, there was no difference in saliva production before and after supplementation (1.91 ± 0.11 ml/min before vs 2.01 ± 0.12 ml/min after). Analysis of subgroups based on saliva production before supplementation found an increase in saliva secretion in the lower saliva flow group (1.18 ± 0.06 vs 1.38 ± 0.08 ml/min), but no change in the higher saliva flow group (2.63 ± 0.11 vs 2.64 ± 0.15 ml/min). These results suggest that Chlorella-derived multicomponent supplementation increases saliva production in individuals with lower levels of saliva secretion.

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“…Clinical tests have suggested that lycopene has beneficial effects in the treatment of oral lichen planus cancer, oral submucous fibrosis, leukoplakia, and periodontitis (by reducing both gingivitis and bacterial plaque), as well as the symptoms of burning mouth syndrome (23)(24)(25)(26). Because of lycopene's biological actions and its pleasant taste, and in light of the reported positive effect of the other antioxidative agent CoQ10 on salivary secretion, it was decided to carry out the present clinical trial on xerostomia patients (22). The present study found that the topical application of spray alleviated symptoms whether or not it contained the active substance.…”

Section: Discussionmentioning

confidence: 99%