Effects of coffee (Coffea arabica) consumption on the femoral morphology and biomechanics in rats

Santos, M. P.; Pagani, J. C. M.; Silva, T. D.; Garcia, José Antônio Dias; Romào, M. O. C.; Fernandes, Geraldo José Medeiros; Soares, Evelise Aline

doi:10.4322/jms.ao062513

Cited by 4 publications

(5 citation statements)

References 26 publications

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“…A study in rats observed negative interference of coffee consumption on the material and structural bone properties, diminishes trabecular and cortical bone density, and hence making bones more fragile and likely to fractures. 8 Human physiological studies and controlled balance studies show a clear but only a very small depressant effect of caffeine on intestinal calcium absorption, and no effect on total 24-h urinary calcium excretion. 9 The epidemiologic studies showing a negative effect may be explained in part by an inverse relationship between consumption of milk and caffeine-containing beverages.…”

Section: Discussionmentioning

confidence: 99%

Life style risk factors for femoral neck fracture in Dr. Sardjito General Hospital, Yogyakarta

2018

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As life expentancy improved, the incidence of femoral neck fracture, as one of the most common traumatic injuries in the elderly, has also increased. Risk for fracture is not only determined by age and sex but also by the degree of osteoporosis and certain lifestyles. The purpose of this study was to investigate lifestyle risk factors for femoral neck fracture in Dr. Sardjito General Hospital, Yogyakarta. In this case-control study, all patients with femoral neck fractures admitted to the Orthopedic Division and Traumatology, Department of Surgery in 2013-2014 was included as cases. Controls were subjects without fracture of similar age and sex. Data of corticosteroid use, habitual coffee consumption, visual acuity disorders, habitual use of slippers and engagement in routine sport activity were collected with questionnaires. We invited 63 patients (51 females and 12 males) and 63 controls. Corticosteroid use, habitual coffee consumption, visual acuity disorder and habitual use of slippers were risks factors for fractures, OR (95% CI) = 7.5 (2.9-21.6), p < 0.001; 7.5 (2.9-21.6), p < 0.001; 3.2 (1.6-6.8), p < 0.001 and 5.7 (2.7-12.6), p < 0.001, respectively. Engagement in routine sport activity was a protecting factor, OR (95% CI) = 0.10 (0.02-0.33), p < 0.001. In conclusion, corticosteroid use, habitual coffee consumption, visual acuity disorder and habitual use of slippers are risk for fractures, while engagement in routine sport is a protecting factor.

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Section: Discussionmentioning

confidence: 99%

Life style risk factors for femoral neck fracture in Dr. Sardjito General Hospital, Yogyakarta

2018

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“…Hasil dari penelitian ini menunjukkan bahwa konsumsi kopi robusta dapat menurunkan kekuatan tulang. Hasil tersebut sesuai dengan penelitian serupa yang pernah dilakukan mengenai efek konsumsi kopi (Coffea arabica) terhadap biomekanika tulang femur pada tikus yang diberi konsumsi kopi selama 60 hari [6]. Penelitian tersebut membuktikan bahwa biomekanika pada sifat mekanis tulang femur dengan pengujian Three Point Bending Test pada kelompok perlakuan yang diberi konsumsi kopi arabika secara signifikan lebih rapuh dibandingkan dengan kontrol.…”

Section: Pembahasanunclassified

“…Biomekanika terbagi menjadi 2 yaitu struktur mekanis tulang (ukuran, volume, arsitektur tulang) dan sifat mekanis tulang (sel, matriks organik, matriks anorganik tulang) [6]. Hal tersebut sesuai dengan hasil uji Anova dalam penelitian ini yang menunjukkan bahwa tidak terdapat perbedaan yang signifikan pada penimbangan berat badan (BB) tikus minggu 1, minggu 2, d a n minggu 3, s e r t a p a d a penimbangan massa sampel tulang dan luas permukaan sampel tulang femur tikus wistar jantan.…”

Section: Pembahasanunclassified

Konsumsi Kopi Robusta Menurunkan Kekuatan Tulang Femur Tikus Wistar Jantan

Andalusia¹,

Hasan²,

Wisudanti³

2018

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Caffeine in coffee is suspected to decrease the bone mineral density and increase the risk factor of osteoporosis, however the contents of coffee is not only caffeine. Considering the great number of people consuming coffee daily, therefore, the study is conducted to investigate the effect of robusta coffee consumption on the femoral bone strength in male wistar rats. Thirty male wistar rats were subjected for the study. They were divided into three groups, i.e control group (K) without robusta coffee consumption, treatment group 1 (P1) with robusta coffee consumption of 0,9 mg/gBW, and treatment group 2 (P2) with robusta coffee consumption of 2,7 mg/gBW. After 21 days, the rats were terminated and the right and the left femurs were collected for force bone test. The force bone test of P1 and P2 group demonstrated weaker bones than K group, and there was no difference effect of P1 group compared to P2 group on the femoral bone strength in male wistar rats. It can be concluded that robusta coffee consumption has negative effect on the bone strenght and hence causing bones more fragile, and there was no difference on effect of 0,9 mg/g BW compared to 2,7 mg/g BW.

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“…Intakes of caffeine in amounts >300 mg/dl led to low mineralization of the bone organic matrix present in the rat femur (Rapuri et al, 2001). Coffee consumption interferes negatively with bone material and structural qualities and decreases femur trabecular and cortical bone volume (Santos et al, 2018). On the other hand, Sakamoto et al, (2001) found through analyses of bone histomorphometry and serum and urinary biomarkers of bone turnover that coffee consumption did not lead to bone resorption in normal conditions.…”

Section: Introductionmentioning

confidence: 99%

Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats

Dal‐Fabbro¹,

Cosme‐Silva

Capalbo³

et al. 2021

Int Endodontic J

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Aim To evaluate the effect of excessive caffeine intake on the inflammation/resorption processes associated with periapical periodontitis (PP) in rats. Methodology Sixteen Wistar rats were used. Periapical periodontitis was induced in the four first molars in each animal. The animals were arranged into two groups: control (C)—rats with periapical periodontitis; and caffeine (CAF)—rats with periapical periodontitis under caffeine administration protocol. The CAF animals received 10 mg/100 g of body weight/day of caffeine via gavage starting fifteen days before PP induction and continuing for thirty more days until euthanasia. On the 30th day, the animals were euthanized and the jaws removed for microcomputed tomography, histological and immunohistochemical analysis for RANKL, OPG, TRAP, IL‐10, TNF‐⍺ and IL‐1β. The Mann–Whitney test was performed for nonparametric data, and Student's t test was performed for parametric data, using p < .05. Results There was no significant difference in the weight change between the groups. The median score of the inflammatory process was significantly greater in the CAF group (3) compared with the C group (2), p = .0256. Bone resorption was greater in the group consuming caffeine (1.08 ± 0.15 mm3) compared with the C group (0.88 ± 0.10 mm3), p = .0346. The immunolabelling for RANKL, TRAP and IL‐1β was significantly higher in the CAF group when compared to the control, p < .05. No differences were found for the OPG, IL‐10 and TNF‐⍺ immunolabelling. Conclusion Excessive caffeine exposure via gavage in rats was able to exacerbate the volume of periapical bone destruction, and the inflammatory pattern deriving from periapical periodontitis altering the expression of RANKL, IL‐1β and TRAP.

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Effects of coffee (Coffea arabica) consumption on the femoral morphology and biomechanics in rats

Cited by 4 publications

References 26 publications

Life style risk factors for femoral neck fracture in Dr. Sardjito General Hospital, Yogyakarta

Life style risk factors for femoral neck fracture in Dr. Sardjito General Hospital, Yogyakarta

Konsumsi Kopi Robusta Menurunkan Kekuatan Tulang Femur Tikus Wistar Jantan

Excessive caffeine intake increases bone resorption associated with periapical periodontitis in rats

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