Effects of Coffee Consumption against the Development of Liver Dysfunction. A 4-Year Follow-Up Study of Middle-Aged Japanese Male Office Workers.

Abstract

controlling for age, body mass index, alcohol intake, and cigarette smoking. These results suggest that coffee may be protectively against the liver dysfunction in middle-aged Japanese men.

Association of caffeine intake and histological features of chronic hepatitis C

“…A large population-based study in the United States has shown that caffeine consumption is associated with a lower risk of elevated serum alanine aminotransferase (ALT) activity in patients at high risk of liver disease [1]. Epidemiological surveys conducted in Europe and Japan also found inverse correlations between coffee drinking and aminotransferases [2][3][4][5] or c-glutamyltransferase [2,3,[6][7][8][9][10][11][12][13] serum levels. Coffee and caffeine consumption has been shown to be associated with a reduced risk of fibrosis or cirrhosis in several prospective studies [14][15][16][17][18][19][20].…”

Coffee, liver enzymes, cirrhosis and liver cancer

“…These span from liver enzymes, to cirrhosis and to hepatocellular carcinoma, and therefore constitute a continuation not only of epidemiological data, but also of biological and clinical evidences.Coffee consumption, in fact, has been inversely related to gamma-glutamyltransferase (GGT) activity in studies from Norway, Italy, Finland, France, Japan and the United States [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. The inverse relation was particularly strong in high risk subjects, including heavy alcohol drinkers [3,4,6,[8][9][10].…”

The association of coffee intake with liver cancer incidence and chronic liver disease mortality in male smokers

“…Coffee consumption has been reported to be inversely associated with enzymes indicative of liver disease and damage (Arnesen et al , 1986; Kono et al , 1994; Poikolainen and Vartiainen, 1997; Tanaka et al , 1998; Nakanishi et al , 2000; Ruhl and Everhart, 2005), fibrosis and cirrhosis in cross-sectional studies (Modi et al , 2010; Muriel and Arauz, 2010), and liver disease progression (Freedman et al , 2009). Coffee may also be associated with lower cancer risk.…”