Effects of combined OncoTherad immunotherapy and probiotic supplementation on modulating the chronic inflammatory process in colorectal carcinogenesis

Reis, Sabrina Karen; Socca, Eduardo Augusto Rabelo; Souza, Bianca Ribeiro de; Genaro, Sandra Cristina; Fávaro, Wagner José

doi:10.1016/j.tice.2022.101747

Cited by 10 publications

(5 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the results of the previous studies [ 39 – 43 ], DMH and its metabolites as a carcinogen induce the different levels of inflammation, precancerous, weight loss [ 44 ], and cancerous lesions. Weight loss is associated with the colon cancer [ 45 ], and the main possible reason for the weight loss would be the reduced function of the colon epithelium, which mainly caused by a wide inflammation that led to a lower absorption of feed [ 44 ]. Dolara et al [ 46 ] proved the ability of oral antioxidants to diminish the effects and lesions induced by DMH.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anticarcinogenic Potentials of Propolis for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats

Salehi

Hosseini

Kazemi

2022

BioMed Research International

View full text Add to dashboard Cite

Propolis is a natural compound with anticarcinogenic properties. The present study aimed to compare the inhibitory effect of ethanolic extract of propolis (EEP) and vitamin E on dimethylhydrazine-induced colon lesions in rats. In this study, 60 rats were randomly categorized into six 10-member groups. After 13 weeks, blood and colon tissue were sampled to examine some factors. The parameters included red (RBC) and white (WBC) blood cell profile, lactate dehydrogenase (LDH), C-reactive protein (CRP), total protein (TP), creatine kinase (CPK), and albumin, as well as the extent of colon histological lesions, protein expression (adenomatous polyposis coli (APC), proliferating cell nuclear antigen (PCNA), carcinoembryonic antigen (CEA), and platelet-derived growth factor (PDGF)), and oxidative stress markers (total antioxidant capacity (TAC), malondialdehyde (MDA), and superoxide dismutase (SOD)) in colon tissue. A significant decrease was observed in congestion, mitotic index, inflammation, and cell destruction in colon tissue in dimethylhydrazine group in comparison with the control group ( P < 0.05 ). The EEP exposed rats exhibited a significant lower oxidative stress than the DMH group ( P < 0.05 ). Furthermore, the extract significantly affected TAC level ( P < 0.05 ). While the expression level of APC rose substantially in the EEP-treated group compared to the DMH group, the level of PCNA, CEA, and PDGF proteins significantly reduced. It seems that the EEP can efficiently prevent DMH-induced colonic lesions. Furthermore, its effectiveness is more than the vitamin E, which is a strong antioxidant.

show abstract

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anticarcinogenic Potentials of Propolis for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats

Salehi

Hosseini

Kazemi

2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The advances of using combinations of multiple probiotic organisms to balance pro- and anti-inflammatory signals are highlighted, as described by other research teams too [ 67 , 68 , 69 , 70 ]. Indeed, we also observed that combining B. lactis, L. acidophilus, L. plantarum and S. boulardii resulted in a moderate, but statistically significant, upregulation of both chemokine and healing factor expression, highlighting again the importance of using multiple probiotics.…”

Section: Discussionmentioning

confidence: 99%

The Probiotic Strains Bifidοbacterium lactis, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Saccharomyces boulardii Regulate Wound Healing and Chemokine Responses in Human Intestinal Subepithelial Myofibroblasts

et al. 2022

View full text Add to dashboard Cite

Bifidobacterium lactis, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Saccharomyces boulardii are common probiotic supplements. Colonic subepithelial myofibroblasts (cSEMFs) are actively involved in mucosal wound healing and inflammation. cSEMFs, isolated from healthy individuals, were stimulated with 102 or 104 cfu/mL of these probiotic strains alone and in combination, and their effect on chemokine and wound healing factor expression was assessed by qRT-PCR, ELISA and Sircol Assay, and on cSEMFs migration, by Wound Healing Assay. These strains remained viable and altered cSEMFs’ inflammatory and wound healing behavior, depending on the strain and concentration. cSEMFs treated with a combination of the four probiotics had a moderate, but statistically significant, increase in the mRNA and/or protein expression of chemokines CXCL1, CXCL2, CXCL4, CXCL8, CXCL10, CCL2 and CCL5, and healing factors, collagen type I and III, fibronectin and tissue factor. In contrast, when each strain was administered alone, different effects were observed, with greater increase or decrease in chemokine and healing factor expression, which was balanced by the mixture. Overall, this study highlights that the use of multiple probiotic strains can potentially alert the gut mucosal immune system and promote wound healing, having a better effect on mucosal immunity than the use of single probiotics.

show abstract

“…Targeting TLR2 may be one of the treatment targets for cancer treatment. Many studies on the above topic suggest that activating TLR2 deserves careful evaluation of its application in cancer therapy, enhancing the growth of cancer cells and migration and inhibiting TLR2 may constitute combined effective strategies for cancer treatment 200,201 …”

Section: Tlr‐related Diseasesmentioning

confidence: 99%

Toll‐like receptors in health and disease

Wang,

Huang,

Zhan

et al. 2024

MedComm

View full text Add to dashboard Cite

Toll‐like receptors (TLRs) are inflammatory triggers and belong to a family of pattern recognition receptors (PRRs) that are central to the regulation of host protective adaptive immune responses. Activation of TLRs in innate immune myeloid cells directs lymphocytes to produce the most appropriate effector responses to eliminate infection and maintain homeostasis of the body's internal environment. Inappropriate TLR stimulation can lead to the development of general autoimmune diseases as well as chronic and acute inflammation, and even cancer. Therefore, TLRs are expected to be targets for therapeutic treatment of inflammation‐related diseases, autoimmune diseases, microbial infections, and human cancers. This review summarizes the recent discoveries in the molecular and structural biology of TLRs. The role of different TLR signaling pathways in inflammatory diseases, autoimmune diseases such as diabetes, cardiovascular diseases, respiratory diseases, digestive diseases, and even cancers (oral, gastric, breast, colorectal) is highlighted and summarizes new drugs and related clinical treatments in clinical trials, providing an overview of the potential and prospects of TLRs for the treatment of TLR‐related diseases.

show abstract

Effects of combined OncoTherad immunotherapy and probiotic supplementation on modulating the chronic inflammatory process in colorectal carcinogenesis

Cited by 10 publications

References 65 publications

Antioxidant and Anticarcinogenic Potentials of Propolis for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats

Antioxidant and Anticarcinogenic Potentials of Propolis for Dimethylhydrazine-Induced Colorectal Cancer in Wistar Rats

The Probiotic Strains Bifidοbacterium lactis, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Saccharomyces boulardii Regulate Wound Healing and Chemokine Responses in Human Intestinal Subepithelial Myofibroblasts

Toll‐like receptors in health and disease

Contact Info

Product

Resources

About