Effects of compressive ratio and sintering temperature on mechanical properties of biocompatible collagen/hydroxyapatite composite scaffolds fabricated for bone tissue engineering

Islam, Shariful; Rahman, Abul Kalam Md. Lutfor; Sharif, Md Hamim; Khan, Alam; Abdulla-Al-Mamun, Md.; Todo, Mitsugu

doi:10.1080/21870764.2019.1600226

Cited by 14 publications

(6 citation statements)

References 48 publications

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“…HAP-1400 exhibits large grains, on the order of tens of microns (10.7–11.4 µm or more) and closed porosity, with pore sizes between 1.3–2.6 µm. When the sintering temperature was increased, the porosities of the HAp specimens were reduced due to the higher densification of the material [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Hydroxyapatite from Natural Sources for Medical Applications

et al. 2022

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The aim of this work is to study the physical-chemical, mechanical, and biocompatible properties of hydroxyapatite obtained by hydrothermal synthesis, at relatively low temperatures and high pressures, starting from natural sources (Rapana whelk shells), knowing that these properties influence the behavior of nanostructured materials in cells or tissues. Thus, hydroxyapatite nanopowders were characterized by chemical analysis, Fourier-transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). In vitro studies on osteoblast cell lines (cytotoxicity and cell proliferation), as well as preliminary mechanical tests, have been performed. The results showed that the obtained powders have a crystallite size below 50 nm and particle size less than 100 nm, demonstrating that hydrothermal synthesis led to hydroxyapatite nanocrystalline powders, with a Ca:P ratio close to the stoichiometric ratio and a controlled morphology (spherical particle aggregates). The tensile strength of HAp samples sintered at 1100 °C/90 min varies between 37.6–39.1 N/mm2. HAp samples sintered at 1300 °C/120 min provide better results for the investigated mechanical properties. The coefficient of friction has an appropriate value for biomechanical applications. The results of cell viability showed that the cytotoxic effect is low for all tested samples. Better cell proliferation is observed for osteoblasts grown on square samples.

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Section: Resultsmentioning

confidence: 99%

Hydroxyapatite from Natural Sources for Medical Applications

et al. 2022

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“…The growth of cells and tissue in all tissue engineering scaffolds is limited by the supply of oxygen and nutrients and, consequently, the extension of vascularization in the scaffold core. − Many researchers have introduced interconnected macropores or channels into scaffolds to facilitate the ingrowth of blood vessels (BVs). − The infiltration of BVs and the seeding of osteoprogenitor cells throughout the scaffold are facilitated by macropores with diameters of 100–300 μm. , It has been demonstrated that the size and area percentage of the formed BVs in the scaffolds increase as the size of the interconnecting region (channel size) between the macropores increases. , However, the details of this correlation remain unknown due to the nonuniform channel sizes. The influence of channel size on angiogenesis and osteogenesis should be clarified using scaffolds with precisely size-controlled channels.…”

Section: Introductionmentioning

confidence: 99%

Honeycomb Scaffolds Fabricated Using Extrusion Molding and the Sphere-Packing Theory for Bone Regeneration

Hayashi

Ishikawa

2020

ACS Appl. Bio Mater.

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Osteoconductive scaffolds can be used to treat large bone defects that arise due to accidents, tumors, congenital defects, and age-related ailments. Carbonate apatite is a promising material for the fabrication of scaffolds because its composition is analogous to that of natural bone. Here, three types of carbonate apatite honeycomb scaffolds with uniaxially penetrating precisely sizecontrolled channels were fabricated using extrusion molding as a base technique. The channel sizes of the scaffolds were varied, with the other parameters kept approximately identical, to correlate channel size with angiogenesis and osteogenesis. The scaffold struts were constructed by interconnecting the carbonate apatite spheres based on the theory of sphere packing; thus, micropores of predictable sizes were formed in the struts. In vivo animal experiments indicated that the size of the formed blood vessels in the scaffolds increased ∼fivefold as the channel size increased from 170 to 285 μm. Moreover, the large channels promoted the formation and maturation of bone tissue. We concluded that the channel size significantly affected angiogenesis within the scaffolds, thereby impacting bone regeneration. The results of this study may contribute to the fabrication of scaffolds for tissue regeneration techniques that involve angiogenesis as an underlying mechanism.

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“…An in vitro stem cell line cultured over the Coll/HAP scaffold exhibits cell adhesion and proliferation. Thus, designing pure HAP with Coll/HAP can be useful to obtain intended scaffolds with better mechanical properties with different pore sizes, which showed great significance in tissue engineering …”

Section: Functionalized Hap Involved In Tissue Engineering Applicationsmentioning

confidence: 99%

“…Thus, designing pure HAP with Coll/HAP can be useful to obtain intended scaffolds with better mechanical properties with different pore sizes, which showed great significance in tissue engineering. 94 Development of nanofiber based material with PCL/n-HAP was followed by electrospinning with a unique concentration of zinc oxide (ZnO). Higher concentrations of ZnO (15% and 30%) lead to excellent antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) and result in a decrease in mechanical strengths and cell viability.…”

Section: Functionalized Hap Involved In Tissue Engineering Applicationsmentioning

confidence: 99%

Functionalized Porous Hydroxyapatite Scaffolds for Tissue Engineering Applications: A Focused Review

Bhat

Uthappa

Altalhi

et al. 2021

ACS Biomater. Sci. Eng.

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Biomaterials have been widely used in tissue engineering applications at an increasing rate in recent years. The increased clinical demand for safe scaffolds, as well as the diversity and availability of biomaterials, has sparked rapid interest in fabricating diverse scaffolds to make significant progress in tissue engineering. Hydroxyapatite (HAP) has drawn substantial attention in recent years owing to its excellent physical, chemical, and biological properties and facile adaptable surface functionalization with other innumerable essential materials. This focused review spotlights a brief introduction on HAP, scope, a historical outline, basic structural features/properties, various synthetic strategies, and their scientific applications concentrating on functionalized HAP in the diverse area of tissue engineering fields such as bone, skin, periodontal, bone tissue fixation, cartilage, blood vessel, liver, tendon/ligament, and corneal are emphasized. Besides clinical translation aspects, the future challenges and prospects of HAP based biomaterials involved in tissue engineering are also discussed. Furthermore, it is expected that researchers may find this review expedient in gaining an overall understanding of the latest advancement of HAP based biomaterials.

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Effects of compressive ratio and sintering temperature on mechanical properties of biocompatible collagen/hydroxyapatite composite scaffolds fabricated for bone tissue engineering

Abstract: (2019) Effects of compressive ratio and sintering temperature on mechanical properties of biocompatible collagen/hydroxyapatite composite scaffolds fabricated for bone tissue engineering,

Cited by 14 publications

References 48 publications

Hydroxyapatite from Natural Sources for Medical Applications

Hydroxyapatite from Natural Sources for Medical Applications

Honeycomb Scaffolds Fabricated Using Extrusion Molding and the Sphere-Packing Theory for Bone Regeneration

Functionalized Porous Hydroxyapatite Scaffolds for Tissue Engineering Applications: A Focused Review

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