Effects of copper nanoparticles in porous TiO2 coatings on bacterial resistance and cytocompatibility of osteoblasts and endothelial cells

Zhang, Xiangyu; Li, Jianfang; Wang, Xin; Wang, Yueyue; Hang, Ruiqiang; Huang, Xiaobo; Tang, Bin; Chu, Paul K.

doi:10.1016/j.msec.2017.08.061

Cited by 111 publications

(64 citation statements)

References 43 publications

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“…Still, the rate of morbidity and mortality because of the microbial infections is high . Therefore, it is important to find out novel strategies and develop new antimicrobial agent by easy, fast, and environment‐friendly route with a broad‐spectrum of antimicrobial activity . Progress in the research continues, which has produced different organic and inorganic nanomaterials for their bio‐ and medicinal applications .…”

Section: Introductionmentioning

confidence: 99%

“…However, most of the nanostructured (NS) thin films are not suitable for antimicrobial and antiviral studies. Particularly, the NS metal films like Cu, Ag, Ti, and Au have been reported to have good antibacterial behaviors. Further, the cost‐effectiveness and the easy accessibility of Cu has made it a better option to work with, since it shares characteristic properties similar to those of expensive Ag, Au, and other noble metals.…”

Section: Introductionmentioning

confidence: 99%

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Direct synthesis of magnetron sputtered nanostructured Cu films with desired properties via plasma chemistry for their efficient antibacterial application

Kim

Sahu

Xiang

et al. 2018

Plasma Processes & Polymers

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By changing the power density, the microstructure, surface morphology, surface energy, and electrical conductivity of the magnetron sputtered Cu films are tuned at a fixed Cu atomic content and the amount of Cu ion release. Data reveals that films with good crystallinity, low surface roughness, minimum surface energy, and the lowest electrical resistivity have shown a strong antibacterial response of Gram-positive bacteria Staphylococcus aureus up to 90-96%. The correlation between the plasma chemistry and film properties is established to investigate the optimized film properties. A possible mechanism is hypothesized to elucidate the observed antibacterial property from the viewpoint of charge transfer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Direct synthesis of magnetron sputtered nanostructured Cu films with desired properties via plasma chemistry for their efficient antibacterial application

Kim

Sahu

Xiang

et al. 2018

Plasma Processes & Polymers

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“…The unique plasmonic properties of metallic nanoparticles have placed them in a privileged spot among other materials in nanoscience [1][2][3] . Copper nanoparticles (CuNPs) have been proposed for a number of applications within photonics 4 , catalysis 5 , nanothermometry 6 , biosensing 7,8 or nanomedicine 9 . Nevertheless, the choice of copper tends to fall behind silver, gold or platinum, probably due to its poor stability, i.e., its tendency towards oxidation.…”

mentioning

confidence: 99%

Optical trapping reveals differences in dielectric and optical properties of copper nanoparticles compared to their oxides and ferrites

Purohit

Samadi

Bendix

et al. 2020

Sci Rep

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In a nanoplasmonic context, copper (Cu) is a potential and interesting surrogate to less accessible metals such as gold, silver or platinum. We demonstrate optical trapping of individual Cu nanoparticles with diameters between 25 and 70 nm and of two ionic Cu nanoparticle species, CuFe 2 o 4 and cuZnfe 2 o 4 , with diameters of 90 nm using a near infrared laser and quantify their interaction with the electromagnetic field experimentally and theoretically. We find that, despite the similarity in size, the trapping stiffness and polarizability of the ferrites are significantly lower than those of Cu nanoparticles, thus inferring a different light-particle interaction. One challenge with using Cu nanoparticles in practice is that upon exposure to the normal atmosphere, Cu is spontaneously passivated by an oxide layer, thus altering its physicochemical properties. We theoretically investigate how the presence of an oxide layer influences the optical properties of Cu nanoparticles. Comparisons to experimental observations infer that oxidation of CuNPs is minimal during optical trapping. By finite element modelling we map out the expected temperature increase of the plasmonic cu nanoparticles during optical trapping and retrieve temperature increases high enough to change the catalytic properties of the particles. Scientific RepoRtS |(2020) 10:1198 | https://doi.

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“…Therefore, it is beneficial for bone tissue formation [12]. Moreover, copper exhibits excellent antibacterial properties versus a broad spectrum of bacteria, including gram-positive and gram-negative bacteria by interfering DNA replication and disrupting cell membranes [48][49][50].In particular, there have been some promising studies on the fabrication of antibacterial Cu/CuO-nanoparticles containing Cu-incorporated TiO 2 coatings on cp-Ti by using the MAO technique for the last five years [42,45,[51][52][53][54][55][56]. Wu et al investigated the formation and investigation of antibacterial resistances of Cu-incorporated TiO 2 coatings by MAO and hydrothermal treatment (HT) [42].…”

mentioning

confidence: 99%

“…In particular, there have been some promising studies on the fabrication of antibacterial Cu/CuO-nanoparticles containing Cu-incorporated TiO 2 coatings on cp-Ti by using the MAO technique for the last five years [42,45,[51][52][53][54][55][56]. Wu et al investigated the formation and investigation of antibacterial resistances of Cu-incorporated TiO 2 coatings by MAO and hydrothermal treatment (HT) [42].…”

mentioning

confidence: 99%

Characterization, Bioactivity and Antibacterial Properties of Copper-Based TiO2 Bioceramic Coatings Fabricated on Titanium

Durdu

2018

Coatings

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The bioactive and anti-bacterial Cu-based bioceramic TiO 2 coatings have been fabricated on cp-Ti (Grade 2) by two-steps. These two-steps combine micro-arc oxidation (MAO) and physical vapor deposition-thermal evaporation (PVD-TE) techniques for dental implant applications. As a first step, all surfaces of cp-Ti substrate were coated by MAO technique in an alkaline electrolyte, consisting of Na 3 PO 4 and KOH in de-ionized water. Then, as a second step, a copper (Cu) nano-layer with 5 nm thickness was deposited on the MAO by PVD-TE technique. Phase structure, morphology, elemental amounts, thickness, roughness and wettability of the MAO and Cu-based MAO coating surfaces were characterized by XRD (powder-and TF-XRD), SEM, EDS, eddy current device, surface profilometer and contact angle goniometer, respectively. The powder-and TF-XRD spectral analyses showed that Ti, TiO 2 , anatase-TiO 2 and rutile-TiO 2 existed on the MAO and Cu-based MAO coatings' surfaces. All coatings' surfaces were porous and rough, owing to the presence of micro sparks through MAO. Furthermore, the surface morphology of Cu-based MAO was not changed. Also, the Cu-based MAO coating has more hydrophilic properties than the MAO coating. In vitro bioactivity and in vitro antibacterial properties of the coatings have been investigated by immersion in simulated body fluid (SBF) at 36.5 • C for 28 days and bacterial adhesion for gram-positive (S. aureus) and gram-negative (E. coli) bacteria, respectively. The apatite layer was formed on the MAO and Cu-based MAO surfaces at post-immersion in SBF and therefore, the bioactivity of Cu-based MAO surface was increased to the MAO surface. Also, for S. aureus and E. coli, the antibacterial properties of Cu-based MAO coatings were significantly improved compared to one of the uncoated MAO surfaces. These results suggested that Cu-based MAO coatings on cp-Ti could be a promising candidate for biomedical dental implant applications.TiO 2 -based coatings have been suggested to improve corrosion resistance, bioactivity and biocompatibility of implant surfaces. They have recently received great attention for the biomedical applications owing to their more stable chemical composition [11,12]. TiO 2 were fabricated on cp-Ti by various surface coating methods including sol-gel [13], anodic oxidation [14], magnetron sputtering [15], electrophoretic deposition [16], acid etching [17,18], laser surface treatment [19], plasma spraying [20,21] and micro arc oxidation [22][23][24][25] etc. However, certain problems like non-homogenous structure, micro-structural control problems, micro-cracks formation, the presence of phase impurity, poor adhesion strength were observed in these methods except for MAO technique [26][27][28]. Thus, implant application areas of the coatings produced by these techniques are limited.Micro-arc oxidation (MAO) is one of the most applicable methods to deposit a porous and rough bioceramic layer on valve metals such as Ti, Al, Mg, and Zr surfaces [3,[29][30][31]. The MAO coating promotes bioacti...

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Effects of copper nanoparticles in porous TiO2 coatings on bacterial resistance and cytocompatibility of osteoblasts and endothelial cells

Cited by 111 publications

References 43 publications

Direct synthesis of magnetron sputtered nanostructured Cu films with desired properties via plasma chemistry for their efficient antibacterial application

Direct synthesis of magnetron sputtered nanostructured Cu films with desired properties via plasma chemistry for their efficient antibacterial application

Optical trapping reveals differences in dielectric and optical properties of copper nanoparticles compared to their oxides and ferrites

Characterization, Bioactivity and Antibacterial Properties of Copper-Based TiO2 Bioceramic Coatings Fabricated on Titanium

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