Effects of corticosterone within the hypothalamic arcuate nucleus on food intake and body weight in male rats

Izzi‐Engbeaya, Chioma; Ma, Yue; Buckley, Niki; Ratnasabapathy, Risheka; Richardson, Errol; Counsell, John R.; Fernandes-Freitas, Isabel; Norton, Mariana; Farooq, Gala; Mirza, Zainab; Cai, Mingzhu; Cheetham, Sharon C.; Murphy, Kevin G.; Dhillo, Waljit S.; Gardiner, James

doi:10.1016/j.molmet.2020.02.015

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…These results suggest that linear growth was restored within 6 months from the acute event, but the lean mass lost during hospitalization was not fully recovered and the fat mass has increased simultaneously. Furthermore, despite all patients having received nutritional advice to follow after hospital discharge, they were following anti‐inflammatory cortisone therapy from dismission up to 10 days later, which is known to lead to hyperphagia and redistribution of lean mass and fat mass (37). Studies on adults patients, affected by SARS‐CoV‐19, reported that a long stay in the hospital could rise the risk of malnutrition induced by weight loss, reduced appetite, and difficulty in feeding in patients especially those with mechanical ventilation (continuous positive airways pressure mask) (38,39).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Anthropometry and Body Composition in Children With SARS-CoV-2-Associated Multisystem Inflammatory Syndrome

Profio

Vizzuso

Fiore

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: Acute coronavirus disease 2019 infection has been shown to negatively affect body composition among adult and malnourished or obesity children. Our aim is to longitudinally evaluate body composition in children affected by the Multisystem Inflammatory Syndrome (MIS-C). Methods: In this cohort study, we recruited 40 patients affected by MIS-C, aged 2–18 years old, who were admitted in our clinic between December 2020 and February 2021. Physical examination for each participant included weight, height, body mass index (BMI) z score, circumferences, and skinfolds assessment. The same measurements were repeated during outpatient follow-up at 10 (T2), 30 (T3), 90 (T4), and 180 (T5) days after hospital discharge. Fat mass and fat free mass were calculated according to skinfolds predictive equations for children and adolescents. A control group was randomly selected among patients attending a pediatric nutritional outpatient clinic. Results: BMI z score significantly decrease between preadmission and hospital discharge. Similarly, arm circumference z score, arm muscular area z score, and arm fat area z score significantly decreased, during hospital stay. Fat mass index (FMI) significantly increased over time, peaking at T3. Fat free mass index decreased during hospitalization. Conclusions: To the best of our knowledge, this is the first study to assess body composition in a numerically large pediatric MIS-C population from acute infection to 6 months after triggering event. FMI and anthropometric parameters linked to fat deposits were significantly higher 6 months after acute event. Thus, limiting physical activity and having sedentary lifestyle may lead to an accumulation of adipose tissue even in healthy children who experienced MIS-C and long hospitalization.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Anthropometry and Body Composition in Children With SARS-CoV-2-Associated Multisystem Inflammatory Syndrome

Profio

Vizzuso

Fiore

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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“…At the same time, alendronate can also substantially improve weight gain [31,32]. The improvement in body weight and food intake may better reflect the results of the improvement in bone metabolism and glucose metabolism [33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice

Zhou

Guan

Liu

et al. 2022

Aging

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Background: To explore the anti-osteoporosis and anti-diabetes effects and potential underlying mechanisms of treatment with metformin and alendronate in diabetes mellitus mice. Methods: Eight-week-old C57 BL/KS db/db and db/+ female mice were evaluated according to the following treatment group for 12 weeks: control group, diabetes mellitus group, diabetes mellitus with metformin group, diabetes mellitus with Alendronate group, diabetes mellitus with metformin plus alendronate group. Glucose level, glucose tolerance test, bone mineral density, bone microarchitecture, bone histomorphometry, serum biomarkers, and qPCR analysis. Results: Combined metformin and alendronate can improve progression in glucose metabolism and bone metabolism, including blood glucose levels, blood glucose levels after 4 and 16 hours fasting, glucose tolerance test results, insulin sensitivity and reduces bone loss than the diabetes group. The use of alendronate alone can increase significantly serum glucagon-like peptide-1 levels than the diabetes group. The use of metformin alone can improve bone microstructure such as Tb.Sp and Tb.N of spine in diabetic mice. Conclusion: The combined use of alendronate and metformin has an anti-diabetes and anti-osteoporotic effect compared with diabetic mice, but they appear to act no obvious synergistically between alendronate and metformin.

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“…Unfortunately, the fight and strife between human groups has prevented, so far, a complete universalization of this primary objective. Food insecurity is a main cause of stress [938,939], which represents a corticosteroid-dominated regulatory milieu [940,941] in the context of the modulation of feeding by the brain [942][943][944]. (d) Social enviroment and its effects on psychology and behavior.…”

Section: Pattern Of Development Of the Msmentioning

confidence: 99%

The Metabolic Syndrome, a Human Disease

Alemany

2024

IJMS

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This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of related but rather independent pathologies. The human nature of MS (its exceptionality in Nature and its close interdependence with human action and evolution) is presented and discussed. The text also describes the close interdependence of its components, with special emphasis on the description of their interrelations (including their syndromic development and recruitment), as well as their consequences upon energy handling and partition. The main theories on MS’s origin and development are presented in relation to hepatic steatosis, type 2 diabetes, and obesity, but encompass most of the MS components described so far. The differential effects of sex and its biological consequences are considered under the light of human social needs and evolution, which are also directly related to MS epidemiology, severity, and relations with senescence. The triggering and maintenance factors of MS are discussed, with especial emphasis on inflammation, a complex process affecting different levels of organization and which is a critical element for MS development. Inflammation is also related to the operation of connective tissue (including the adipose organ) and the widely studied and acknowledged influence of diet. The role of diet composition, including the transcendence of the anaplerotic maintenance of the Krebs cycle from dietary amino acid supply (and its timing), is developed in the context of testosterone and β-estradiol control of the insulin-glycaemia hepatic core system of carbohydrate-triacylglycerol energy handling. The high probability of MS acting as a unique complex biological control system (essentially monophyletic) is presented, together with additional perspectives/considerations on the treatment of this ‘very’ human disease.

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Effects of corticosterone within the hypothalamic arcuate nucleus on food intake and body weight in male rats

Cited by 8 publications

References 22 publications

Longitudinal Anthropometry and Body Composition in Children With SARS-CoV-2-Associated Multisystem Inflammatory Syndrome

Longitudinal Anthropometry and Body Composition in Children With SARS-CoV-2-Associated Multisystem Inflammatory Syndrome

The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice

The Metabolic Syndrome, a Human Disease

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