Effects of Creatine Supplementation on Body Composition and Renal Function in Rats

Ferreira, Larissa Gorayb; Bergamaschi, Cássia T.; Lazaretti-Castro, Marise; Heilberg, Ita Pfeferman

doi:10.1249/01.mss.0000177555.94271.44

Cited by 26 publications

(37 citation statements)

References 26 publications

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“…Taes et al (2003) failed to demonstrate any deleterious effects of CR intake in rats with kidney failure or normal kidney function whereas others have found a reduction on GFR in physically inactive rats (Ferreira et al 2005) or exacerbation of disease progression in an animal model of cystic kidney disease (Edmunds et al 2001). However, species-and tissue-specific response to CR intake has been consistently demonstrated (Tarnopolsky et al 2003;Harris et al 1992;Sewell and Harris 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, these studies have numerous severe limitations (e.g., retrospective design, lack of the subjects' clinical background, absence of information regarding the CR purity, use of other nutritional supplements and medications along with CR), thus preventing any definitive conclusion. Furthermore, it has been showed that CR may induce deleterious effects in rodents (Edmunds et al 2001;Ferreira et al 2005). However, the relevance of such findings is debatable, since several studies have indicated that animals respond differently from humans when ingesting CR (Tarnopolsky et al 2003;Harris et al 1992;Sewell and Harris 2002).…”

Section: Introductionmentioning

confidence: 99%

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Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial

et al. 2010

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Creatine supplementation may have a therapeutic role in diabetes, but it is uncertain whether this supplement is safe for kidney function. The aim of this study was to investigate the effects of creatine supplementation on kidney function in type 2 diabetic patients. A randomized, double-blind, placebo-controlled trial was performed. The patients were randomly allocated to receive either creatine or placebo for 12 weeks. All the patients underwent exercise training throughout the trial. Subjects were assessed at baseline and after the intervention. Blood samples and 24-h urine samples were obtained for kidney function assessments. Additionally, 51 Cr-EDTA clearance was performed. To ensure the compliance with creatine intake, we also assessed muscle phosphorylcreatine content. The creatine group presented higher muscle phosphorylcreatine content when compared to placebo group (CR Pre 44 ± 10, Post 70 ± 18 mmol/kg/wt; PL Pre 52 ± 13, Post 46 ± 13 mmol/kg/wt; p = 0.03; estimated difference between means 23.6; 95% confidence interval 1. 42-45.8). No significant differences were observed for 51 Cr-EDTA clearance (CR Pre 90.4 ± 16.9, Post 96.1 ± 15.0 mL/min/1.73 m 2 ; PL Pre 97.9 ± 21.6, Post 96.4 ± 26.8 mL/min/1.73 m 2 ; p = 0.58; estimated difference between means -0.3; 95% confidence interval -24.9 to 24.2). Creatinine clearance, serum and urinary urea, electrolytes, proteinuria, and albuminuria were unchanged. CR supplementation does not affect kidney function in type 2 diabetic patients, opening a window of opportunities to explore its promising therapeutic role in this population. ClinicalTrials.gov registration number: NCT00992043.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial

et al. 2010

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“…Ferreira et al (27) investigaram os efeitos da suplementação de creatina em ratos saudáveis submetidos ou não a treinamento. Nesse trabalho, quatro grupos foram estudados por 10 semanas: creatina + exercício (Cr+E); creatina isolada (Cr); placebo + exercício (Pl+E); placebo isolado (Pl).…”

Section: Estudos Com Animaisunclassified

“…Taes et al (26) declararam que a creatina empregada em seu trabalho possuía grau de pureza maior que 99%. Em contrapartida, Ferreira et al (27) não realizaram teste de pureza em seu estudo.…”

Section: Estudos Com Animaisunclassified

A suplementação de creatina prejudica a função renal?

Gualano

Ugrinowitsch

Seguro

et al. 2008

Rev Bras Med Esporte

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Enquanto o consumo de creatina por atletas e praticantes de atividade física tem crescido vertiginosamente, os efeitos adversos desse suplemento continuam sendo alvos de calorosos debates científicos, sobretudo no que se refere à função renal. O objetivo dessa revisão é descrever as falhas metodológicas e lacunas na literatura, que contribuem para a divergência do tema. Relatos de caso sugerem que a creatina é um potencial agente nefrotóxico. Em contrapartida, estudos longitudinais, embora possuam diversas limitações, indicam o oposto. Pesquisas com humanos não demonstram efeitos deletérios da suplementação de creatina à função renal, porém a falta de controle experimental e o caráter retrospectivo da maioria delas comprometem as conclusões dos autores. Já os estudos experimentais com ratos empregam bons marcadores de função renal e possuem controle de variáveis satisfatório. Contudo, os resultados destes são contraditórios. Estudos futuros devem investigar os efeitos da suplementação de creatina em diversas patologias renais, assim como em idosos, diabéticos do tipo 2 e hipertensos, cuja propensão a nefropatia é bem descrita. Não há evidências de que a suplementação de creatina prejudique a função renal em sujeitos saudáveis, quando consumida na dosagem preconizada. Diante disso, questiona-se a legitimidade científica da proibição do comércio de creatina no Brasil. Palavras-chave: efeitos adversos, suplementos alimentares, creatinina, cistatina C, rim ABSTRACTWhile creatine consumption has been greatly increasing among athletes and physical activity practitioners, the adverse effects of this supplement remain scientifically controversial, especially concerning renal function. The aim of this review is to describe the methodological limitations and gaps in the literature which contribute to the topic's divergence. Case reports suggest that creatine is a nephrotoxic agent. On the other hand, despite having several limitations, longitudinal studies have indicated the opposite. Research with humans does not demonstrate any deleterious effects as a consequence of creatine supplementation; however, the absence of experimental control as well as their retrospective characteristics compromise the authors' conclusion. Experimental studies with animal models though, use both gold standard for renal function and have satisfactory variable control. However, the results remain controversial. Future studies should investigate the effects of creatine supplementation in several kidneys diseases as well as in the elderly, type 2 diabetis and hypertensive individuals, whose tendency to renal dysfunction is well-described. There is not evidence that creatine supplementation causes renal deterioration in healthy subjects when it is ingested in the recommended dosage. Thus, we have some concerns about the sale prohibition of creatine supplementation in Brazil.Keywords: adverse effects, food supplements, creatinine, cystatin C, kidney INTRODUÇãOA creatina (ácido α-metil guanidino acético) é uma amina de ocorrência natural encontrad...

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“…Studies have shown that creatine supplementation did not cause damage to kidney and liver function in rats 31,32 . However, some experimental and clinical studies have associated its supplementation to some side effects, such as the appearance of hepatitis, harmful effects on glomerular filtration rate and on renal plasma flow 33,34 .…”

Section: Introductionmentioning

confidence: 99%

Study of renal and hepatic toxicity in rats supplemented with creatine

Baracho

Castro²,

Borges³

et al. 2015

Acta Cir. Bras.

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PURPOSE:To evaluate the renal and hepatic function, through biochemical analysis after 14 days of creatine supplementation in physically inactive rats. METHODS:Twenty four male, adult, Wistar rats were used which were kept in individual metabolic cages and were distributed into four groups, and received the following treatments by gavage:1) Control: distilled water; 2)Creatine 0.5g/Kg/day; 3) Creatine 1g/Kg/ day; 4) Creatine 2g/Kg/day. Their urinary outputs as well as food and water intake were daily measured. At the end of the experiment, the animals were euthanized and serum samples were stored for biochemical analysis. RESULTS:Creatine supplementation at the doses given produced no significant changes in plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total protein, albumin, total cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol, triglycerides, glucose, creatinine, urea, and creatinine clearance, compared to control group (p> 0.05) Similarly, water and food intake, as well as urinary output, did not show significant changes among the four groups studied. CONCLUSION:At the doses used, oral creatine supplementation did not result in renal and/or hepatic toxicity.

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Effects of Creatine Supplementation on Body Composition and Renal Function in Rats

Abstract: Creatine supplement in combination with exercise increased the proportion of lean mass more than EX or CREAT alone. The use of creatine alone induced an important and significant reduction of both RPF and GFR.

Cited by 26 publications

References 26 publications

Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial

Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial

A suplementação de creatina prejudica a função renal?

Study of renal and hepatic toxicity in rats supplemented with creatine

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