Effects of CRH and LHRH on Rat Septo-Hippocampal Neurons.

Osada, Takashi

doi:10.1507/endocrj.44.519

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Moreover, these results suggest that the Fos expression observed here in the MS and VDB of sleep deprived grass rats could be secondary to the activation of the stress axis. This is because the BF of lab rats contains receptors for corticotrophin releasing hormone [CRH; 51], a hormone released by the pPVN upon exposure to a stressful stimulus, and because delivery of CRH to the BF alters neural firing of neurons in the MS and VDB [52]. Against this interpretation is the fact that grass rats that are voluntarily awake at night [11], and supposedly not under stress, show similar patterns of Fos expression in the MS and VDB to those observed in this study.…”

Section: Discussionmentioning

confidence: 99%

Fos expression in arousal and reward areas of the brain in grass rats following induced wakefulness

Castillo‐Ruiz

Núñez

2011

Physiology & Behavior

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In the diurnal grass rat nocturnal voluntary wakefulness induces Fos expression in specific cellular populations of arousal and reward areas of the brain. Here, we evaluated whether involuntary wakefulness would result in similar patterns of Fos expression. We assessed this question using male grass rats that were sleep deprived for 6 h by gentle stimulation (SD group), starting 2 h before lights off (12:12 LD cycle). Then, we examined expression of Fos in cholinergic cells of the basal forebrain (BF), as well as in dopaminergic cells of the reward system, and compared these results to those obtained from an undisturbed control group. Different from previous results with grass rats that were voluntary awake, the BF of SD animals only showed a significant increase in Fos expression in non-cholinergic neurons of the medial septum (MS). These observations differ from reports for nocturnal rodents that are sleep deprived. Thus, our results show that voluntary and induced wakefulness have different effects on neural systems involved in wakefulness and reward, and that the effects of sleep deprivation are different across species. We also investigated whether other arousal promoting regions and circadian and stress related areas responded to sleep deprivation by changing the level of Fos expression. Among these areas, only the lateral hypothalamus (LH) and the ventro lateral preoptic area showed significant effects of sleep deprivation that dissipated after a 2 h period of sleep recovery, as it was also the case for the non-cholinergic MS. In addition, we found that Fos expression in the LH was robustly associated with Fos expression in other arousal and reward areas of the brain. This is consistent with the view that the arousal system of the LH modulates neural activity of other arousal regions of the brain, as described for nocturnal rodents.

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Section: Discussionmentioning

confidence: 99%

Fos expression in arousal and reward areas of the brain in grass rats following induced wakefulness

Castillo‐Ruiz

Núñez

2011

Physiology & Behavior

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“…The MS and VDB of mice and laboratory rats contain the corticotropin-releasing hormone (CRH) receptor 1 (Radulovic et al, 1998), and in mice there is a high degree of colocalization of this receptor and ACh in neurons in both areas (Sauvage and Steckler, 2001). Furthermore, in laboratory rats CRH stimulates neuronal activity in the MS and VDB (Osada, 1997). Thus, experimental wakefulness paradigms may induce widespread Fos expression in ACh cells of the VDB due to the actions of CRH on these neurons, but only when stress responses are involved.…”

Section: Discussionmentioning

confidence: 99%

Neural activation in arousal and reward areas of the brain in day-active and night-active grass rats

et al. 2010

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In the diurnal unstriped Nile grass rat (Arvicanthis niloticus) access to a running wheel can trigger a shift in active phase preference, with some individuals becoming night-active (NA), while others continue to be day-active (DA). To investigate the contributions of different neural systems to the support of this shift in locomotor activity, we investigated the association between chronotype and Fos expression during the day and night in three major nuclei in the basal forebrain (BF) cholinergic (ACh) arousal system – medial septum (MS), vertical and horizontal diagonal band of Broca (VDB and HDB respectively) –, and whether neural activation in these areas was related to neural activity in the orexinergic system. We also measured Fos expression in dopaminergic and non-dopaminergic cells of two components of the reward system that also participate in arousal – the ventral tegmental area (VTA) and supramammillary nucleus (SUM). NAs and DAs were compared to animals with no wheels. NAs had elevated Fos expression at night in ACh cells, but only in the HDB. In the non-cholinergic cells of the BF of NAs, enhanced nocturnal Fos expression was almost universally seen, but only associated with activation of the orexinergic system for the MS/ VDB region. For some of the areas and cell types of the BF, the patterns of Fos expression of DAs appeared similar to those of NAs, but were never associated with activation of the orexinergic system. Also common to DAs and NAs was a general increase in Fos expression in non-dopaminergic cells of the SUM and anterior VTA. Thus, in this diurnal species, voluntary exercise and a shift to a nocturnal chronotype changes neural activity in arousal and reward areas of the brain known to regulate a broad range of neural functions and behaviors, which may be also affected in human shift workers.

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Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei – potential implication for arousal and attention

2001

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Effects of CRH and LHRH on Rat Septo-Hippocampal Neurons.

Cited by 4 publications

References 35 publications

Fos expression in arousal and reward areas of the brain in grass rats following induced wakefulness

Fos expression in arousal and reward areas of the brain in grass rats following induced wakefulness

Neural activation in arousal and reward areas of the brain in day-active and night-active grass rats

Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei – potential implication for arousal and attention

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