Effects of crude aqueous extract of Carica papaya seeds in male albino mice

Chinoy, N. J.; D'Souza, Joe; Padman, Priya

doi:10.1016/0890-6238(94)90070-1

Cited by 31 publications

(18 citation statements)

References 4 publications

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“…These results are of clinical importance and should have a possible practical use in the gastrointestinal tract to prevent transfer of antibiotic-resistance genes between bacteria that are targets for antibiotic chemotherapy. Yet, it should be pointed out that the ingestion of C. papaya seeds is not harmful or toxic in rats (Chinoy, 1994). Therefore, the phenomena herein observed permit us to suggest that diet may be an important factor influencing gene exchange among enteric bacteria, opening a natural route to control or minimize the dissemination of resistance genes.…”

Section: Discussionmentioning

confidence: 90%

Carica papaya seed macerate as inhibitor of conjugative R plasmid transfer from Salmonella typhimurium to Escherichia coli in vitro and in the digestive tract of gnotobiotic mice

Leite

Nardi

Nicoli

et al. 2005

J. Gen. Appl. Microbiol.

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Section: Discussionmentioning

confidence: 90%

Carica papaya seed macerate as inhibitor of conjugative R plasmid transfer from Salmonella typhimurium to Escherichia coli in vitro and in the digestive tract of gnotobiotic mice

Leite

Nardi

Nicoli

et al. 2005

J. Gen. Appl. Microbiol.

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“…In this context, C. papaya seeds water extract could be a source to exploit. In fact, papaya seeds contain several molecules, like fatty acids, crude protein, crude fiber, papaya oil, carpaine, benzyl isothiocyanate, glucotropaeolin, benzyl thiourea, hentriacontane, β -sitosterol, caricin, and an enzyme myrosin [7] that confer vermifuge [25, 26], abortifacient [27, 28], antifertility [29–32], wound-healing [33], anticancer [34], antibacterial [35], and antifungal [36] properties as well as antioxidant activities for the presence of secondary metabolites, such as phenolic compounds, vanillic acid, flavonoids, α -tocopherol, and vitamin C. Despite the wide and historical use of C. papaya in the traditional management of many diseases [4], the scientific validation of the use of papaya seeds as antioxidant is scarce. Therefore, in the present work we tested C. papaya seeds water extract that conforms to the use in folk medicine and ensures no toxicity related to chemicals used during the preparation.…”

Section: Discussionmentioning

confidence: 99%

Administration Dependent Antioxidant Effect of Carica papaya Seeds Water Extract

Panzarini

Dwikat

Mariano

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Carica papaya is widely used in folk medicine as herbal remedy to prevent, protect against, and cure several diseases. These curative properties are based on the presence in different parts of the plant of phytochemical nutrients with antioxidant effect. Seeds are the less exploited part; thus this study is aimed at assessing the antioxidant activities of the C. papaya seeds water extract against hydrogen peroxide (H2O2) oxidative stress in human skin Detroit 550 fibroblasts. C. papaya seeds water extract is not toxic and acts as a potent free radical scavenger, providing protection to Detroit 550 fibroblasts that underwent H2O2 oxidative stress. Data show that (i) the maximum protective effect is achieved by the simultaneous administration of the extract with 1 mM H2O2; (ii) the extract in presence of an oxidative stress does not increase catalase activity and prevents the release of cytochrome C and the inner mitochondrial transmembrane potential (Δψ m) loss; (iii) the extract is more efficient than vitamin C to hamper the oxidative damage; (iv) the purified subfractions of the seeds water extract exert the same antioxidant effect of whole extract. In conclusion, C. papaya seeds water extract is potentially useful for protection against oxidative stress.

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“…It is also used in the treatment of chronic skin ulcer and as a diuretic [10]. Research on Carica papaya seed extract concerns mainly antifertility properties [11][12][13]. Th e oral administration of C. papaya seed extract can induce reversible male infertility [12].…”

Section: Original Articlementioning

confidence: 99%

Thrombocyte counts in mice after the administration of papaya leaf suspension

Sathasivam

Ramanathan

Mansor

et al. 2009

Wien Klin Wochenschr

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Following up a popular use of crude leaf preparations from Carica papaya for the treatment of dengue infections, a suspension of powdered Carica papaya leaves in palm oil has been investigated for its effect on thrombocyte counts in mice, administering by gavage 15 mg of powdered leaves per kg body weight to 5 mice. Equal numbers of animals received corresponding volumes of either palm oil alone or physiological saline solution. Thrombocyte counts before and at 1, 2, 4, 8, 10, 12, 24, 48 and 72 hours after dosing revealed significantly higher mean counts at 1, 2, 4, 8, 10 and 12 after dosing with the C. papaya leaf formulation as compared to the mean count at hour 0. There was only a non-significant rise of thrombocyte counts in the group having received saline solution, possibly the expression of a normal circadian rhythm in mice. The group having received palm oil only showed a protracted increase of platelet counts that was significant at hours 8 and 48 and obviously the result of a hitherto unknown stimulation of thrombocyte release. The results call for a dose-response investigation and for extending the studies to the isolation and identification of the C. papaya substances responsible for the release and/or production of thrombocytes.

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Effects of crude aqueous extract of Carica papaya seeds in male albino mice

Cited by 31 publications

References 4 publications

Carica papaya seed macerate as inhibitor of conjugative R plasmid transfer from Salmonella typhimurium to Escherichia coli in vitro and in the digestive tract of gnotobiotic mice

Carica papaya seed macerate as inhibitor of conjugative R plasmid transfer from Salmonella typhimurium to Escherichia coli in vitro and in the digestive tract of gnotobiotic mice

Administration Dependent Antioxidant Effect of Carica papaya Seeds Water Extract

Thrombocyte counts in mice after the administration of papaya leaf suspension

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