Effects of Curcuma as an adjunct therapy on periodontal disease: A systematic review and meta-analysis

Oliveira, Rubelisa Cândido Gomes de; Costa, Camila Alves; Costa, Nádia Lago; Silva, Gabriela Camilo; Souza, João Antônio Chaves de

doi:10.1016/j.ctcp.2021.101493

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…Relevant evidence exhibited that Cur can effectively prevent and treat oral diseases, such as oral mucositis (OM) (GRADE level: low) and chronic periodontitis (GRADE level: moderate) (Dharman et al, 2021; Guo et al, 2021; Souza et al, 2021; Terby et al, 2021; Yuan, 2019; Zhang, Tang, & Wei, 2021). However, the results of several studies failed to show a positive effect of oral disease (GRADE level: low) (Al‐Maweri et al, 2021; Oliveira et al, 2021; Zhang, Huang, et al, 2021). None of the studies mentioned above reported publication bias.…”

Section: Resultsmentioning

confidence: 99%

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zhang

Deng

Tang

et al. 2022

Phytotherapy Research

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This umbrella review is to recapitulate and grade the available evidence of associations between consumption of Zingiberaceae plants/curcumin (Cur) and multiple health‐related outcomes. This study included 161 meta‐analyses of randomized controlled trials in 76 articles with 67 unique health outcomes. Data on heterogeneity and publication bias are considered to assess the quality of evidence. Based on the different impact of Zingiberaceae plants/Cur on human health, the advantages outweigh the disadvantages. Zingiberaceae plants/Cur can mainly improve metabolic syndrome, non‐alcoholic fatty liver disease, cardiovascular disease, and some chronic inflammatory diseases, likewise, obviously relief the pain of osteoarthritis and related diseases. Ginger supplements have been shown to improve vomiting during pregnancy and to relieve nausea and vomiting caused by chemotherapy and surgery. The surgery is any type of surgery, including laparoscopic surgery, gynecological surgery and mixed surgery. Beneficial associations were found with Cur intervention in gastrointestinal, neurological and oral diseases. Zingiberaceae plants/Cur are generally safe and favorable for multiple health outcomes in humans. High‐quality research is further needed to prove the observed associations.

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Section: Resultsmentioning

confidence: 99%

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zhang

Deng

Tang

et al. 2022

Phytotherapy Research

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“…It has been reported that the anti-inflammatory actions of CU could be associated with inhibiting the mRNA and protein expression of cyclo-oxygenase-2 via down regulation of NF-κB activation ( Plummer et al, 1999 ), and reducing the activity of phospholipase and lipoxygenase ( Yamamoto et al, 1997 ; Began et al, 1998 ). However, further studies have been suggested to provide concrete evidence on the beneficial effects of CU on reduction of probing pocket depth and clinical attachment loss ( Oliveira et al, 2021 ; Zhang et al, 2022 ). It is important to acknowledge that the effects of locally administered CU gel on the level inflammatory biomarkers of IL-6, MMP-8, CRP, ALP, and IL-10 in blood in comparison to Tetracycline have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Effect of Curcumin gel on inflammatory and anti-inflammatory biomarkers in experimental induced periodontitis in rats: a biochemical and immunological study

Mohammad,

Ali,

Sha

et al. 2023

Front. Microbiol.

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This study aimed to determine the effect of local application of curcumin gels as adjunct to scaling and root planing (SRP) on the inflammatory biomarkers matrix metalloproteinase-8 (MMP-8), interleukin-6 (IL-6), C-reactive protein (CRP), and alkaline phosphatase (ALP), and the anti-inflammatory biomarker interleukin-10 (IL-10) in rats with experimentally induced periodontitis. Fifty-five adult Wistar rats with experimentally induced periodontitis were randomly divided into four groups: 15 rats received SRP + curcumin gel (CU), 15 rats received SRP + Tetracycline gel (Tet), 15 rats were treated with SRP alone, and 5 rats had experimental periodontitis without treatment (EP). Five systemically healthy rats without experimental periodontitis were used as the controls. Blood samples were collected by cardiac puncture from all groups after 2, 4, and 6 weeks of therapy. Biomarker levels determined by enzyme-linked immunosorbent assay (ELISA) and, ANOVA were used to compare the study groups. The results showed a significant increase in pro-inflammatory biomarkers and a significant decrease in anti-inflammatory biomarkers in the EP group compared with the control group (p < 0.05). The local application of curcumin or tetracycline gels resulted in a significant reduction in all inflammatory biomarkers at all periods of examination compared to the EP group. IL-10 levels gradually increased after 2 weeks, peaked at 4 weeks, and then decreased after 6 weeks, however, Tet showed statistically significant improvement compared to CU (p < 0.05). Adjunctive application of CU gel was as effective as Tet gel in the treatment of EP in rats by reducing inflammatory biomarkers and enhancing anti-inflammatory cytokines.

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Toward the use of Boesenbergia rotunda extracts and the chalcone panduratin A to treat periodontitis

Bailly

2022

Journal of Oral Biosciences

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Effects of Curcuma as an adjunct therapy on periodontal disease: A systematic review and meta-analysis

Cited by 5 publications

References 46 publications

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

Effect of Curcumin gel on inflammatory and anti-inflammatory biomarkers in experimental induced periodontitis in rats: a biochemical and immunological study

Toward the use of Boesenbergia rotunda extracts and the chalcone panduratin A to treat periodontitis

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