Effects of Curcumin on Alveolar Bone Loss in Experimental Periodontitis in Rats: A Morphometric and Histopathologic Study

Abstract

Abstract. Background: Curcumin is found in the rhizomes of the turmeric plant that has been showed antioxidant and anti-inflammatory effect. The aim of this study was to evaluate the effects of systemic curcumin therapy on alveolar bone loss in an experimental periodontitis model in rats. Material and Methods: Thirty-two male Wistar rats were randomly divided to 4 groups: 75 mg/kg/daily curcumin (C75; n =8), 150 mg/kg/daily curcumin (C150; n =8), Control (n =8), and Ligated (n =8). Curcumin was administrated using gastric gavage. After 12 days, the rats were sacrificed. Right mandibles samples were histopathologically examined. Alveolar bone loss was measured. Interleukin 1β (IL-1β) and interleukin 10 (IL-10) were evaluated in the serum samples and gingival homogenates. Results: The measurements of alveolar bone loss in the mandibular molars revealed significantly higher bone-loss values in the Ligated group than the Control, C75 and C150 groups. The IL-1β levels in the gingival homogenates were significantly increased in the Ligated group compared to those of the Control, C75 and C150 groups. The serum IL-1β levels in the Ligated group were significantly higher than the Control group. The mean osteoblast numbers in the Ligated group were lower than those of the Control, C75 and C150 groups. The C150 groups showed significantly more osteoblasts than the Control group. The osteoclast numbers in the Ligated group increased significantly compared to the C75, C150 and control groups. Conclusion: This study demonstrates that systemic administration of curcumin at the 75 and 150mg/kg doses reduced alveolar bone loss in the periodontal disease in rats. Keywords: Alveolar bone loss, Antioxidant, Curcumin, Ligature-induced, Histomorphometric, Micronutrition

Exploring the Therapeutic Potential of Curcumin for Periodontal Regeneration

“…Clinical trials have demonstrated that curcumin can reduce gingival inflammation when used with scaling and oral gel containing Curcuma longa extract is efficient in treating initial infective inflammatory periodontal disease [74]. Animal studies have shown that natural curcumin can inhibit the inflammatory process and reduction in alveolar bone loss in experimentally induced periodontitis [75][76][77][78]. However, the need of human studies to better evaluate properties of curcumin in treatment of periodontitis has been highlighted [79].…”

Novel regimens of phytopolyphenols with cisplatin or memantine and ZnSO4 for synergistic inhibition of growth and gingipains of the cultured Porphyromonas gingivalis

“… 26 , 27 , 28 , 29 Both curcumin and tea polyphenols possessed antioxidant, antiinflammatory, anti-carcinogenicity, immune-modulatory, antibacterial and neuroprotective effects. Moreover, both curcumin 30 , 31 , 32 , 33 and tea polyphenols 34 , 35 were shown to be the promising antibacterial agents for the therapy of periodontitis. Thus, these natural products combined with Cis or Mem especially further combined with ZnSO 4 17 , 18 , 19 (an antibacterial and immunomodulatory agent) against P.g.…”

Herbal Preparation (Bromelain, Papain, Curcuma, Black Pepper) Enhances Mineralization and Reduces Glucocorticoid-Induced Osteoporosis in Zebrafish

“…CHP has been made using Curcuma longa , Piper nigrum , bromelain and papain. Curcumin, a component of Curcuma longa extract, has powerful anti-inflammatory and antioxidant activities [ 24 ], and it has important molecular targets that participate in the regulation of bone metabolism and remodeling [ 25 , 26 ]. Nevertheless, low bioavailability of curcumin is a great limitation for clinical development [ 27 ].…”