Effects of dexamethasone on cardiovascular functions in acute phase in meconium‐injured rabbits

Mokrá, Daniela; Tonhajzerová, Ingrid; Petraskova, M; Čalkovská, Andrea

doi:10.1111/j.1442-200x.2008.02674.x

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…However, we do not have data to support this assumption. Similar effects on oxygenation were observed in a study performed in rabbits after meconium-instillation [12].…”

Section: Discussionsupporting

confidence: 85%

“…It is also known that glucocorticoids have a positive effect on gas exchange related to better matching of ventilation and perfusion caused by a decrease in lung edema and in bronchoconstriction [12]. Macrolides are known to have anti-inflammatory and immune modulatory properties that attenuate local airway and systemic inflammation [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Preemptive Therapy with Steroids but Not Macrolides Improves Gas Exchange in Caustic-Injured Donor Lungs

Meers

Wauters

Verbeken

et al. 2011

Journal of Surgical Research

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“…However, we do not have data to support this assumption. Similar effects on oxygenation were observed in a study performed in rabbits after meconium-instillation [12].…”

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Preemptive Therapy with Steroids but Not Macrolides Improves Gas Exchange in Caustic-Injured Donor Lungs

Meers

Wauters

Verbeken

et al. 2011

Journal of Surgical Research

View full text Add to dashboard Cite

“…The possible rationales for the use of corticosteroids in PPHN are the beneficial pharmacologic effects on the cardiovascular system and their anti-inflammatory properties. 43,44 There is evidence suggesting that steroids are effective in the treatment of refractory hypotension in neonates without an increase in short-term adverse consequences via enhancing the vasoconstrictor actions of α-adrenergic agonists (norepinephrine), angiotensin II, arginine vasopressin, endothelin (ET), and thromboxane. 45 In addition, steroids significantly improve oxygenation by increasing superoxide dismutase activity and reducing oxidative stress.…”

Section: Corticosteroid Therapymentioning

confidence: 99%

The Practical Challenges of Diagnosis and Treatment Options in Persistent Pulmonary Hypertension of the Newborn: A Developing Country's Perspective

Nakwan

2018

Amer J Perinatol

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Persistent pulmonary hypertension of the newborn (PPHN) is a complication of several respiratory diseases characterized by an elevation in pulmonary vascular resistance with resultant right-to-left shunting of blood and severe hypoxemia in the neonatal period. PPHN carries a high rate of morbidity and mortality, particularly in limited-resource settings (low-income and/or developing country). Echocardiography remains the gold standard for diagnosis of PPHN. Modern therapies such as inhaled nitric oxide, high-frequency oscillatory ventilation, extracorporeal membrane oxygenation, and/or other pulmonary vasodilators agents can reduce the mortality rate of PPHN. Unfortunately, echocardiography and the use of these modern therapies are often difficult for a medical institution to provide for patients in developing countries, even when a timely diagnosis of PPHN has been made. In this review, the practical challenges of timely diagnosis of PPHN and efficient use of available treatment options faced by pediatricians or neonatologists in limited-resource settings are discussed.

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Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits

et al. 2018

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Backgroundchronic hypoxia increases basal ventilation and pulmonary vascular resistance, with variable changes in arterial blood pressure and heart rate, but it’s impact on heart rate variability and autonomic regulation have been less well examined. We studied changes in arterial blood pressure, heart rate and heart rate variability (HRV) in rabbits subjected to chronic normobaric hypoxia (CNH; PB ~ 719 mmHg; FIO2 ~ 9.2%) for 14 days and assess the effect of autonomic control by acute bilateral vagal denervation.Resultsexposure to CNH stalled animal weight gain and increased the hematocrit, without affecting heart rate or arterial blood pressure. Nevertheless, Poincaré plots of the electrocardiographic R–R intervals showed a reduced distribution parallel to the line of identity, which interpreted as reduced long-term HRV. In the frequency domain, CNH reduced the very-low- (< 0.2 Hz) and high-frequency components (> 0.8 Hz) of the R–R spectrograms and produced a prominent component in the low-frequency component (0.2–0.5 Hz) of the power spectrum. In control and CNH exposed rabbits, bilateral vagotomy had no apparent effect on the short- and long-term HRV in the Poincaré plots. However, bilateral vagotomy differentially affected higher-frequency components (> 0.8 Hz); reducing it in control animals without modifying it in CNH-exposed rabbits.ConclusionsThese results suggest that CNH exposure shifts the autonomic balance of heart rate towards a sympathetic predominance without modifying resting heart rate or arterial blood pressure.

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Effects of dexamethasone on cardiovascular functions in acute phase in meconium‐injured rabbits

Abstract: Single-dose i.v. dexamethasone showed a trend to improve gas exchange, however, increased parasympathetic activity, what should be considered in use of corticosteroids in the treatment of meconium aspiration syndrome.

Cited by 3 publications

References 24 publications

Preemptive Therapy with Steroids but Not Macrolides Improves Gas Exchange in Caustic-Injured Donor Lungs

Preemptive Therapy with Steroids but Not Macrolides Improves Gas Exchange in Caustic-Injured Donor Lungs

The Practical Challenges of Diagnosis and Treatment Options in Persistent Pulmonary Hypertension of the Newborn: A Developing Country's Perspective

Effects of vagotomy on cardiovascular and heart rate variability alterations following chronic normobaric hypoxia in adult rabbits

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