Effects of Dietary Calcium upon Lipid Metabolism in Mature Male Rats Fed Beef Tallow

Fleischman, Alan I.; Yacowitz, H.; Hayton, Tom; Bierenbaum, Marvin L.

doi:10.1093/jn/88.3.255

Cited by 65 publications

(29 citation statements)

References 9 publications

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“…Reduced supply of this factor will cause a decrease in the lipogenic activity as was seen in the PTX rats. This finding is contrary to the observation that blood lipids decreased with increasing dietary calcium [18]. The mode of action by which PTH exerts these enzymatic changes in liver and kidney is not clear.…”

Section: Resultscontrasting

confidence: 91%

Biochemical Change in the Liver and Kidney of Rats Following Parathyroidectomy

Bogin¹,

Earon²

1985

Enzyme

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The effect of hypoparathyroidism and low blood calcium on enzyme levels in rat liver and kidney is shown. Four animal groups were used: parathyroidectomized (PTX), PTX with CaCl(2) added in the drinking water, sham-operated controls and sham-operated with CaCl(2) added in the drinking water. PTX significantly lowered serum parathyroid hormone (PTH) and calcium. Supplementation of CaCl(2) in the drinking water increased serum Ca levels in PTX rats but not in the controls. Significant changes in several liver and kidney enzymes were seen. Most affected were the liver NADP dependent enzymes, glucose-6-phosphate dehydrogenase and malic enzyme. Similar patterns but with relatively smaller changes were seen in the liver enzymes, lactic dehydrogenase, hexokinase, and aspartate transferase. No significant differences between the groups were seen in the levels of malic dehydrogenase, isocitric dehydrogenase, fructose-6-phosphate kinase and cholinesterase. In the kidney, which was less affected than the liver, the only significant difference was seen in the level of malic enzyme. Serum total lipids in the PTX group were significantly lower. All the changes seen were partially reversed by Ca supplementation in the drinking water.

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Section: Resultscontrasting

confidence: 91%

Biochemical Change in the Liver and Kidney of Rats Following Parathyroidectomy

Bogin¹,

Earon²

1985

Enzyme

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“…It has been demonstrated in rats that excess calcium in the diet lowers absorp tion of fats (8)(9)(10). There have scarcely been any studies on the possible effect of the level of dietary phosphorus upon the utilization of fat.…”

Section: Discussionmentioning

confidence: 99%

Effect of Excess Calcium Intake on Absorp-Tion of Nitrogen, Fat, Phosphorus and Calcium in Young Rats. The Use of Organic Calcium Salt

Goto

Sawamura

1973

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Experimental studies in albino rats fed a diet high in fat and calcium content was associated with a decrease in blood lipid concentration and an increase in fecal bile acid excretion. 19 In addition, clinical and experimental studies have shown that calcium intake is associated with beneficial CV and blood pressure (BP)-lowering effects. 20,21 The cholesterol-lowering effect of calcium appears to be mediated through its intestinal binding with fatty acids and by decreasing their absorption, 19 whereas its BP-lowering effect is mediated through suppression of plasma renin activity and an amelioration of the BP effects of salt, especially in salt-sensitive hypertensive patients.…”

Section: Studies Demonstrating Significant and Nonsignificant Beneficmentioning

confidence: 99%

“…19 In addition, clinical and experimental studies have shown that calcium intake is associated with beneficial CV and blood pressure (BP)-lowering effects. 20,21 The cholesterol-lowering effect of calcium appears to be mediated through its intestinal binding with fatty acids and by decreasing their absorption, 19 whereas its BP-lowering effect is mediated through suppression of plasma renin activity and an amelioration of the BP effects of salt, especially in salt-sensitive hypertensive patients. 20,21 Other studies have shown that high calcium intake improves BP and diabetes through weight loss and an increase in insulin release and sensitivity.…”

Section: Studies Demonstrating Significant and Nonsignificant Beneficmentioning

confidence: 99%

Controversy Regarding the Association of High Calcium Intake and Increased Risk for Cardiovascular Disease

Chrysant

2014

J of Clinical Hypertension

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Calcium intake has been shown to be associated with beneficial effects regarding hypertension, coronary heart disease (CHD), vascular disease, and stroke by several prospective cohort studies. However, recent studies have questioned the beneficial cardiovascular effects of calcium intake and instead have shown that high calcium intake is associated with an increased risk for CHD and stroke. These findings have created controversy and concern among physicians, because calcium is consumed by a large number of older men and women to prevent osteoporosis and bone fractures. Based on the methods of patient self‐reporting of calcium intake and cardiovascular events, the conclusions drawn from the studies may not be entirely valid. Therefore, until more confirmatory data are available, physicians should not be dissuaded from prescribing calcium supplements to their patients. The best candidates are patients with low calcium intake, but their calcium supplementation should not exceed the recommended 1200 mg/d to 1500 mg/d.

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Effects of Dietary Calcium upon Lipid Metabolism in Mature Male Rats Fed Beef Tallow

Cited by 65 publications

References 9 publications

Biochemical Change in the Liver and Kidney of Rats Following Parathyroidectomy

Biochemical Change in the Liver and Kidney of Rats Following Parathyroidectomy

Effect of Excess Calcium Intake on Absorp-Tion of Nitrogen, Fat, Phosphorus and Calcium in Young Rats. The Use of Organic Calcium Salt

Controversy Regarding the Association of High Calcium Intake and Increased Risk for Cardiovascular Disease

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