Effects of dietary equol on body weight gain, intra-abdominal fat accumulation, plasma lipids, and glucose tolerance in ovariectomized Sprague-Dawley rats

Rachoń, Dominik; Vortherms, Tina; Seidlová-Wuttke, Dana; Wuttke, W.

doi:10.1097/gme.0b013e31802d979b

Cited by 68 publications

(64 citation statements)

References 50 publications

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“…Whereas, 13-week treatment (post) with VA (50 and 100 mg/kg b.wt) considerably alleviated (p < 0.01) those excessive body weight gain which was observed in OVX rats owing to estrogenic activity. Several studies had shown that the substance or drug with estrogenic activity could significantly lower the ovariectomy-induced weight gain (Rachon et al, 2007 and. Also, the UI value was substantially lowered in OVX rats and thus proving that the surgical procedure (atrophy of uterus) was successful.…”

Section: Resultsmentioning

confidence: 97%

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Wang¹,

Jiang²,

Gou³

2017

Afr J Tradit Complement Altern Med

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Background: The need for an anti-osteoporotic agent is in high demand since osteoporosis contributes to high rates of disability or impairment (high osteoporotic fracture), morbidity and mortality. Hence, the present study is designed to evaluate the protective effects of vanillic acid (VA) against bilateral ovariectomy-induced osteoporosis in female Sprague-Dawley (SD) rats. Materials and Methods: Forty healthy female adult SD rats were separated in to four groups with sham-operated control with bilateral laprotomy (Sham; n = 10), bilateral overiectomy (OVX; n = 10) group, OVX rats were orallay administrated with 50 mg/kg b.wt of VA (OVX + 50 VA; n = 10) or 100 mg/kg b.wt of VA (OVX + 100 VA; n = 10) for 12 weeks (post-treatment) after 4 weeks of OVX. Results: A significant change in the body weight gain was noted in OVX group, while treatment with VA substantially reverted to normalcy. Meanwhile, the bone mineral density and content (BMD and BMC) were substantially improved on supplementation with VA. Also, the bone turnover markers like calcium (Ca), phosphorous (P), osteocalcin (OC), alkaline phosphatase (ALP) and deoxypyridinoline (DPD) and inflammatory markers (IL-1β, IL-6, and TNF-α) levels were markedly attenuated in VA-treated rats. Moreover, the biomechanical stability was greatly ameliorated with VA administration. Both the dose of VA showed potent anti-osteoporotic activity, but VA 100 mg showed highest protective effects as compared with 50 mg of VA. Conclusion: Based on the outcome, we concluded that VA 100 showed better anti-osteoporotic activity by improving BMD and BMC as well as biomechanical stability and therefore used as an alternative therapy for treating postmenopausal osteoporosis.

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Section: Resultsmentioning

confidence: 97%

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Wang¹,

Jiang²,

Gou³

2017

Afr J Tradit Complement Altern Med

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“…Rachon et al reported that a 400 mg/kg diet of dietary equol decreased food intake and body fat in OVX rats. 48) Wu et al reported that the preventive effects of isoflavones on fat accumulation in early postmenopausal women depend on an individual's capacity to produce equol.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of appetite-mediated gene expression in daidzein-fed female rats in the meal-feeding method

Fujitani

Maekawa

Bhattarai

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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We previously found that daidzein decreased food intake in female rats. The present study aimed to elucidate the relationship between dynamics of appetite-mediated neuropeptides and the anorectic effect of daidzein. We examined appetite-mediated gene expression in the hypothalamus and small intestine during the 3 meals per day feeding method. Daidzein had an anorectic effect specifically at the second feeding. Neuropeptide-Y (NPY) and galanin mRNA levels in the hypothalamus were significantly higher after feeding in the control but not in the daidzein group, suggesting that daidzein attenuated the postprandial increase in NPY and galanin expression. The daidzein group had higher corticotrophin-releasing hormone (CRH) mRNA levels in the hypothalamus after feeding, and increased cholelcystokinin (CCK) mRNA levels in the small intestine, suggesting that CCK is involved in the hypothalamic regulation of this　anorectic effect. Therefore, daidzein may induce anorexia by suppressing expression of NPY and galanin and increasing expression of CRH in the hypothalamus.

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“…Conversely, treatment of ovx rats with oestrogen or any substance with estrogenic potential (i.e. phytoestrogens) attenuates ovariectomy induced weight gain and visceral fat deposition (Rachoń et al, 2007a;Rachoń et al, 2007b). Consistently, aromatase deficient or oestrogen receptor alpha (ER ) knockout mice develop obesity and related metabolic abnormalities again suggesting that oestrogen deprivation may play a pivotal role in postmenopausal weight gain in women (Heine et al, 2000;Jones et al, 2006).…”

Section: Menopause Hormonal Changes and Obesitymentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

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137

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Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution.Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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Effects of dietary equol on body weight gain, intra-abdominal fat accumulation, plasma lipids, and glucose tolerance in ovariectomized Sprague-Dawley rats

Cited by 68 publications

References 50 publications

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Protective Effect of Vanillic Acid on Ovariectomy-Induced Osteoporosis in Rats

Dynamics of appetite-mediated gene expression in daidzein-fed female rats in the meal-feeding method

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

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