Effects of dietary fish protein, soybean protein and casein on cholesterol turnover in rats.

Iritani, Nobuko; Rei, Narita; Fujita, Takao; Tanaka, Takehiko

doi:10.3177/jnsv.31.385

Cited by 27 publications

(11 citation statements)

References 30 publications

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“…These results are in good agreement with those previously observed in rats (15,36). However, in this study hepatic cholesterol in rats fed cod protein was significantly different, being intermediate to hepatic cholesterol in rats fed casein and soy protein.…”

Section: Discussionsupporting

confidence: 93%

“…However, in this study hepatic cholesterol in rats fed cod protein was significantly different, being intermediate to hepatic cholesterol in rats fed casein and soy protein. Other studies in rats showed significantly higher hepatic cholesterol concentrations after cod protein feeding compared with soy protein feeding, but cod protein and casein did not induce statistically different effects in these studies (15,36). As with soy protein, it has been postulated that the lower lysine/arginine ratio of cod protein when compared with casein may have played a role in the hypocholesterolemic effect of cod protein (37).…”

Section: Discussionmentioning

confidence: 68%

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Dietary proteins modulate the effects of fish oil on triglyceridemia in the rat

Demonty

Deshaies

Jacques

1998

Lipids

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Sprague-Dawley rats were fed purified diets varying in both protein (20%) and lipid (11%) content for 28 d to verify the independent and interactive effects of dietary proteins and lipids on serum and hepatic lipids, and on tissue lipoprotein lipase (LPL) activity in both fasted and postprandial states. These diets consisted of either casein-menhaden oil, casein-coconut oil, soy protein-menhaden oil (SPMO), soy protein-coconut oil, cod protein-menhaden oil, or cod protein-coconut oil. A randomized 3 x 2 factorial design was used. A significant protein-lipid interaction was seen on serum triglyceride levels: menhaden oil, compared with coconut oil, induced a decrease in serum triglyceride levels when combined with soy protein but not when combined with cod protein and casein. The lower serum triglyceride concentrations observed in the SPMO-fed rats could be the result of decreased hepatic triglycerides when soy protein was compared with casein and when menhaden oil was compared with coconut oil. Total LPL activity in the heart was higher in menhaden oil-fed rats than in coconut oil-fed rats in the postprandial state. The higher LPL activity in the heart could, however, explain only 10% of the reduction of serum triglycerides, contributing slightly to the lowering effects of SPMO diet on serum triglycerides. Therefore, the present results indicate that dietary proteins can modulate the effects of fish oil on triglyceridemia in the rat, and that could be mainly related to specific alterations in hepatic lipid concentrations.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 68%

Dietary proteins modulate the effects of fish oil on triglyceridemia in the rat

Demonty

Deshaies

Jacques

1998

Lipids

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“…In previous studies in rats, fish proteins have been found to decrease plasma TC concentration in comparison with casein. [10][11][12] Hypocholesterolemic effect of fish protein in rats 13 has been attributed to a decrease in liver cholesterol output into the circulation due to a stimulation of cholesterol to bile acid conversion and to increased excretion Fish intake and blood lipids during weight loss I Gunnarsdottir et al of cholesterol and its metabolites into faeces 37 or reduced activity of Acyl-CoA: cholesterol acyltransferace. 38 These observations suggest that fish proteins might have cardioprotective effect and be involved in the regulation of plasma cholesterol.…”

Section: Discussionmentioning

confidence: 99%

Inclusion of fish or fish oil in weight-loss diets for young adults: effects on blood lipids

et al. 2008

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Objective: To assess the effects of fish (lean or oily) and fish oil consumption on blood lipid concentration during weight loss. Design: Randomized, controlled 8-week trial of energy-restricted diet varying in fish and fish oil content. Subjects, 324 men and women, aged 20-40 years, body mass index 27.5-32.5 kg m À2 , from Iceland, Spain and Ireland, were randomized to one of four groups: (1) control (sunflower oil capsules, no seafood), (2) cod diet (3 Â 150 g week À1 ), (3) salmon diet (3 Â 150 g week À1 ), (4) fish oil (DHA/EPA capsules, no seafood). The macronutrient composition of the diets was similar between the groups and the capsule groups were single-blinded. Measurements: Total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein cholesterol, triacylglycerol (TG) and anthropometrics were measured at baseline and end point. Results: The difference in logTG lowering between the control group and the cod diet, salmon diet and fish oil from baseline to end point was À0.036 (95% CI À0.079 to 0.006), À0.060 (À0.101 to À0.018) and À0.037 (À0.079 to 0.006), respectively. Reduction in TC was about 0.2 mmol l À1 greater in the fish groups (cod and salmon) than in the control group, but only of borderline significance when adjusting for weight loss. HDL tended to decrease less in the diet groups consuming a significant amount of n-3 fatty acids (salmon and fish oil). Conclusion: Weight-loss diet including oily fish resulted in greater TG reduction than did a diet without fish or fish oil. Controlled trials using whole fish as a test meal are encouraged to be able to elucidate the role of different constituents of fish for human health.

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“…Many publications have reported that dietary soybean protein showed hy pocholesterolemic effects when compared with animal protein such as casein (1)(2)(3)(4)(5)(6)(7). However, the effects of soybean protein on triglyceride levels were not consistent in the publications and have not been so extensively investigated as the effects on cholesterol level.…”

mentioning

confidence: 99%

Effects of dietary casein and soybean protein on triglyceride turnover in rat liver.

Iritani

Suga

Fukuda

et al. 1988

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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We previously found that hepatic lipogenic enzyme in duction, fatty acid synthesis, and triglyceride level were markedly lower in rats fed soybean protein than in those fed casein (Iritani et al. (1986): J. Nutr., 116: 190). After labeling triglycerides with tritiated water, the effects of dietary protein on the triglyceride degradation have been investigated. After the injection of tritiated water into rats, the radioactivities of fatty acids and triglycerides reached a plateau in 1-2 days and were markedly lower in the soybean protein group than in the casein group. The decreasing rates of triglyceride radioactivities were similar between the casein and soybean protein groups. The enzyme activities in glycerolipid synthesis were similar between the groups. Therefore, the lowering effects of soybean protein on triglyceride levels appear to be ascribed to triglyceride synthesis (due to fatty acid synthesis) rather than to the degradation.

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Effects of dietary fish protein, soybean protein and casein on cholesterol turnover in rats.

Cited by 27 publications

References 30 publications

Dietary proteins modulate the effects of fish oil on triglyceridemia in the rat

Dietary proteins modulate the effects of fish oil on triglyceridemia in the rat

Inclusion of fish or fish oil in weight-loss diets for young adults: effects on blood lipids

Effects of dietary casein and soybean protein on triglyceride turnover in rat liver.

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