Effects of dietary Gelsemium elegans alkaloids on growth performance, immune responses and disease resistance of Megalobrama amblycephala

Ye, Qiao; Yuan, Feng; Wang, Zhenlü; Zhou, Aiguo; Xie, Shaolin; Zhang, Yue; Xiang, Qiong; Song, Enfeng

doi:10.1016/j.fsi.2019.05.026

Cited by 34 publications

(13 citation statements)

References 69 publications

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“…Previous studies have reported that cognitive ability was closely related to the severity of stroke (31,32), which was consistent with our findings. GSH/GSSG and T-AOC levels are both recognized as indicators of antioxidant capacity (33)(34)(35)(36). In the present study, low antioxidant capacity was considered to be associated with PSCI.…”

Section: Discussionmentioning

confidence: 70%

Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke

Hou

Chen

et al. 2020

Ann Transl Med

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Background: Oxidative damage may contribute to post-stroke cognitive impairment (PSCI), but the underlying mechanisms are not fully elucidated. Dimethyl fumarate (DMF) has been used as an antioxidant in multiple sclerosis and psoriasis patients. We hypothesized that redox state was associated with PSCI, and DMF might exert neuroprotective effect against PSCI via anti-oxidative actions.Methods: To confirm this hypothesis, we first conducted a clinical study (NCT03519828) that enrolled patients diagnosed with acute ischemic stroke within 48 hours. Data were analyzed based on demographic characteristics, disease history, clinical data and redox state. Logistic regression was used to identify the factors associated with PSCI. Next, a middle cerebral artery occlusion (MCAO) rat model was used to explore the antioxidant capacity and neuroprotective effect of DMF. Furthermore, behavioural experiments, histology and immunostaining, and transmission electron microscopy were also performed.Results: Higher baseline NIHSS score, lower GSH/GSSG and T-AOC levels were found in the PSCI patients. Better performance in Morris water maze and shuttle box testing, more regular arranged neurons and Nissl bodies, less TUNEL-positive cells and autophagosomes, lower expression of 4-HNE, and higher expression of GCLM and NQO1 were found in the (DMF + MCAO) rats compared with the MCAO rats.Conclusions: These findings suggest that DMF may alleviate PSCI via neuroprotective actions, providing a new therapeutic strategy for PSCI.

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Section: Discussionmentioning

confidence: 70%

Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke

Hou

Chen

et al. 2020

Ann Transl Med

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“…In studies conducted in China, GEB research has focused on its structural composition, pharmacological effects and its growth-promoting effects on poultry and livestock [ 4 , 7 , 29 ]. In aquaculture, the growth-promoting effects of GEB on aquatic animals have not been systematically studied, and the current work intends to fill this knowledge gap using the guidance of previous studies [ 1 , 12 , 30 ]. As a major component of GEB, KM improved the growth and intestinal health of C. carpio.…”

Section: Discussionmentioning

confidence: 99%

“…Aquaculture provides an important source of protein for humans. However, the massive use of antibiotics and chemical drugs in aquaculture to reduce the occurrence of diseases has caused serious consequences, namely the development of drug-resistant pathogens and pollution of the environment [ 1 ]. Healthy, environmentally friendly, and efficient methods for fish cultivation have essential economic benefits.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Dietary Koumine on Growth Performance, Intestinal Morphology, Microbiota, and Intestinal Transcriptional Responses of Cyprinus carpio

Wang

Zuo

et al. 2022

IJMS

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Gelsemium elegans Benth. (GEB) is a traditional medicinal plant in China, and acts as a growth promoter in pigs and goats. Koumine (KM) is the most abundant alkaloid in GEB and produces analgesic, anti-cancer, and immunomodulatory effects. KM can be used as an aquatic immune stimulant, but its growth-promoting effects and transcriptional mechanisms have not been investigated. Diets containing KM at 0, 0.2, 2, and 20 mg/kg were fed to Cyprinus carpio for 71 days to investigate its effects on growth performance, intestinal morphology, microflora, biochemical indicators, and transcriptional mechanisms. Cyprinus carpio fed with KM as the growth promoter, and the number of intestinal crypts and intestinal microbial populations were influenced by KM concentration. KM increased the abundance of colonies of Afipia, Phyllobacterium, Mesorhizobium, and Labrys, which were associated with compound decomposition and proliferation, and decreased the abundance of colonies of pathogenic bacteria Methylobacterium-Methylorubrum. A total of 376 differentially-expressed genes (DEGs) among the four experimental groups were enriched for transforming growth factor-β1 and small mother against decapentaplegic (TGF-β1/Smad), mitogen-activated protein kinase (MAPK), and janus kinases and signal transducers and activators of transcription (Jak/Stat) signaling pathways. In particular, tgfbr1, acvr1l, rreb-1, stat5b, smad4, cbp, and c-fos were up-regulated and positively correlated with KM dose. KM had a growth-promoting effect that was related to cell proliferation driven by the TGF-β1/Smad, MAPK, and Jak/Stat signaling pathways. KM at 0.2 mg/kg optimized the growth performance of C. carpio, while higher concentrations of KM (2 and 20 mg/kg) may induce apoptosis without significantly damaging the fish intestinal structure. Therefore, KM at low concentration has great potential for development as an aquatic growth promotion additive.

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“…Many studies reported that G. elegans alkaloids triggered the immune response by promoting the expression of pro-inflammatory factors [ 20 ] and affect the activation and proliferation of T lymphocytes [ 10 ]. The results of the present study showed that compared with the control group, the counts of neutrophils and leukocytes in the blood of the G. elegans -treated group increased, which indicates that G. elegans improved the cellular immune function and disease resistance of the weaned piglets.…”

Section: Discussionmentioning

confidence: 99%

Integration of Metabolomics and Transcriptomicsto Comprehensively Evaluate the Metabolic Effects of Gelsemium elegans on Pigs

Huang

Yang

Cao

et al. 2021

Animals

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Some naturalphytogenic feed additives, which contain several active compounds, have been shown to be effective alternatives to traditional antibiotics. Gelsemium elegans (G. elegans) is a whole grass in the family Loganiaceae. It is a known toxic plant widely distributed in China and has been used as a traditional Chinese herbal medicine for many years to treat neuropathic pain, rheumatoid pain, inflammation, skin ulcers, and cancer. However, G. elegans not only is nontoxic to animals such as pigs and sheep but also has an obvious growth-promoting effect. To our knowledge, the internal mechanism of the influence of G. elegans on the animal body is still unclear. The goal of this work is to evaluate the metabolic consequences of feeding piglets G. elegans for 45 days based on the combination of transcriptomics and metabolomics.According to growth measurement and evaluation, compared with piglets fed a complete diet, adding 20g/kg G. elegans powder to the basal diet of piglets significantly reduced the feed conversion ratio. Results of the liver transcriptome suggest that glycine and cysteine-related regulatory pathways, including the MAPK signaling pathway and the mTOR signaling pathway, were extensively altered in G. elegans-induced piglets. Plasma metabolomics identified 21 and 18 differential metabolites (p < 0.05) in the plasma of piglets in the positive and negative ion modes, respectively, between G. elegansexposure and complete diet groups. The concentrations of glycine and its derivatives and N-acetylcysteine were higher in theG. elegans exposure group than in the complete diet group. This study demonstrated that G. elegans could be an alternative to antibiotics that improves the immune function of piglets, and the latent mechanism of G. elegans may be related to various signaling pathways, including the MAPK signaling pathway and the PPAR signaling pathway.

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Effects of dietary Gelsemium elegans alkaloids on growth performance, immune responses and disease resistance of Megalobrama amblycephala

Cited by 34 publications

References 69 publications

Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke

Neuroprotective effect of dimethyl fumarate on cognitive impairment induced by ischemic stroke

Effects of Dietary Koumine on Growth Performance, Intestinal Morphology, Microbiota, and Intestinal Transcriptional Responses of Cyprinus carpio

Integration of Metabolomics and Transcriptomicsto Comprehensively Evaluate the Metabolic Effects of Gelsemium elegans on Pigs

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