Effects of dietary lysine levels on jejunal expression of amino
acids transporters and hindgut microflora in weaned pigs

Zhou, Huaijun; Chen, D. w.; Mao, Xiang-bin; He, Jun; Yu, Jing; Zheng, Ping; Luo, Junqiu; Gao, Jinnian; Htoo, J. K.; Yu, Bin

doi:10.22358/jafs/93736/2018

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…Thus, these results were expected once we utilized 90% of the lys recommendation found in the Brazilian Tables (Rostagno et al, 2017). Other studies evaluating lys levels on piglet performance during the first nursery phase also reported that levels below 14.0 g kg-1 of SID lys led to poorer ADG, ADFI, and FC of the animals (Oresanya, Beaulieu, Beltranena, & Patience, 2006;Taylor, Toplis, Wellock, & Miller, 2012;Zhou et al, 2018).…”

Section: Resultsmentioning

confidence: 91%

Effects of glutamine and glutamate on nursery piglets fed diets with different digestible lysine content

Gomes¹,

Júnior²,

Silva³

et al. 2021

Semina: Ciênc. Agrár.

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The objective of the study was to evaluate the effects of glutamine and glutamate (Gln/Glu) on the growth performance and immune response of nursery pigs fed different digestible lysine content. Two hundred and sixteen piglets, weaned at 21 days old, were assigned to a randomized block design according to their initial body weight (BW), in a 2 × 2 factorial arrangement with two levels of lysine (control-lys and low-lys) and two levels of Gln/Glu (0 and 12 g kg-1), with nine replicates. At 26 d, piglets consuming the low-lys diet not supplemented with Gln/Glu presented a higher (P < 0.01) incidence of diarrhea than the other treatments. From 21 to 32 d of age, the piglets fed the control-lys diets performed better than those fed low-lys diets (P < 0.01). From 21 to 42 d of age, there was a correlation (P < 0.01) between lysine level and Gln/Glu supplementation for average daily feed intake (ADFI) and feed conversion (FC). Gln/Glu supplementation improved (P < 0.05) the ADFI of pigs fed the low-lys diets, resulting in a higher (P < 0.01) average daily weight gain (ADG) and BW; however, worse (P < 0.05) FC. Piglets consuming control-lys diets had higher (P < 0.05) serum urea nitrogen concentration (SUN) and IgG than low-lys piglets. In addition, Gln/Glu supplementation correlated with higher (P < 0.01) SUN. Dietary supplementation of glutamine and glutamate improved the growth performance of weaned piglets from 21 to 42 days of age, regardless of the diets’ lysine levels. In addition, reducing lysine levels 10% below the requirement negatively affects the growth performance and the immune response of nursery piglets.

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Section: Resultsmentioning

confidence: 91%

Effects of glutamine and glutamate on nursery piglets fed diets with different digestible lysine content

Gomes¹,

Júnior²,

Silva³

et al. 2021

Semina: Ciênc. Agrár.

View full text Add to dashboard Cite

show abstract

“…Hence, we further investigated the effect on hindgut microbiota. The supplementation and restriction of Lys have been proven to change gut microflora in monogastric animals ( Yin et al., 2017 ; Zhou et al., 2018 ), which was mainly associated with the amount of substrate for bacterial proliferation. In addition, a previous study demonstrated that rumen-protected leucine improved starch utilization by regulating fermentation profiles and amylolytic microbes of the hindgut in dairy calves ( Ren et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Rumen-protected lysine supplementation improved amino acid balance, nitrogen utilization and altered hindgut microbiota of dairy cows

Wei

Wang

et al. 2023

Animal Nutrition

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“…Positive Although gene expression processes are genetically preprogramed, dietary nutrients can activate these processes (Liao et al, 2015;Zhou et al, 2018). The regulation of nutrient transporters in the small intestine is connected with the nutrients present in the diet (Gilbert et al, 2008).…”

Section: Fat Lpl Npc1 Pla2mentioning

confidence: 99%

The Effects of Supplementing Lysophosphatidylcholine (LPC) in the Diet on Production Performance, Fat Digestibility, Blood Lipid Profile, and Gene Expression Related to Nutrients Transport in Small Intestine of Laying Hens

Juntanapum¹,

Bunchasak²,

Poeikhampha³

et al. 2020

J. Anim. Feed Sci.

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This study was conducted to evaluate the effects of lysophosphatidylcholine (LPC) supplementation on egg production, fat digestibility, blood lipid profile and gene expression related to nutrients transport in brown egglaying hens. In total, 384 commercial laying hens were divided into 4 groups (8 replicates, 12 animals each): 1. positive control (PC), 2. negative control (reduced energy to 75 ME kcal/kg; NC), 3. NC-LPC 0.05%, and 4. NC-LPC 0.1%, accordingly to a completely randomized design. There were no significant effects on productive performance during 33-41 weeks of age. Feed intake and feed conversion ratio (FCR) significantly increased (P < 0.05) in the NC group in comparison to the PC group during 42-49 weeks of age. Supplementation of LPC (at both levels) significantly reduced feed intake and FCR (P < 0.05). Consequently, it significantly reduced feed cost per egg weight (P < 0.05). In animals supplemented with LPC increased (P < 0.05) digestibilities of dietary fat, low-density lipoprotein cholesterol (LDL-C), triglyceride and cholesterol in blood were found. The expression of gene BAT in the epithelial layer of the jejunum significantly increased in the NC group, however it decreased in the NC-LPC 0.1% group (P < 0.05). The expression of CAT-1 gene in the NC-LPC 0.1% group was higher than that of the PC group (P < 0.05). The supplemental LPC (both levels) also significantly increased the expression of the NPC1 gene in comparison to the NC group (P < 0.05). So, supplementation of LPC to the diet improved the feed efficiency via the increase of fat digestibility and the uptake of some amino acids or cholesterol to the enterocyte up-regulating the expression of some amino acids and cholesterol transporter genes.

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Effects of dietary lysine levels on jejunal expression of amino acids transporters and hindgut microflora in weaned pigs

Cited by 4 publications

References 42 publications

Effects of glutamine and glutamate on nursery piglets fed diets with different digestible lysine content

Effects of glutamine and glutamate on nursery piglets fed diets with different digestible lysine content

Rumen-protected lysine supplementation improved amino acid balance, nitrogen utilization and altered hindgut microbiota of dairy cows

The Effects of Supplementing Lysophosphatidylcholine (LPC) in the Diet on Production Performance, Fat Digestibility, Blood Lipid Profile, and Gene Expression Related to Nutrients Transport in Small Intestine of Laying Hens

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