Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice

Arai, Kumiko; Mizobuchi, Yu; Tokuji, Yoshihiko; Aida, Kazuhiko; Yamashita, Shinji; Ohnishi, Masao; Kinoshita, Mikio

doi:10.5650/jos.ess15005

Cited by 39 publications

(51 citation statements)

References 25 publications

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“…GlcCer was shown to suppress the production of inflammatory cytokines and chemokines in a previous study that used a different mechanism to induce colon crypt injury 7 , and the pattern of suppression was similar to that observed in the present study. The mechanism underlying the suppressive effect of dietary GlcCer on inflammatory cytokine and chemokine levels induced by these agents remains unknown.…”

Section: Resultssupporting

confidence: 89%

“…In our previous study in a model of DSS-induced colitis, dietary GlcCer suppressed chemokine production, especially IP-10 and MIG, and chorionic crypt injury 7 . DSS, a mucopolysaccharide, induced damage to the colon epidermal cells after oral administration.…”

Section: Resultsmentioning

confidence: 74%

“…Dietary GlcCer suppressed DSS-induced body weight loss. Moreover, dietary GlcCer significantly suppressed the production of cytokines by the intestinal mucosa 7 .…”

Section: Introductionmentioning

confidence: 93%

“…The experimental diets used were based on AIN-76 i.e. control diet , not containing sphingolipids 3,10 , and supplemented with GlcCer 1 g/kg diet, 0.1 7 . All protocols involving animals were approved by the Animal Care and Use Committee and conducted in accordance with the Obihiro University Guidelines.…”

Section: Animals and Dietmentioning

confidence: 99%

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Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

et al. 2017

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 74%

“…Dietary GlcCer suppressed DSS-induced body weight loss. Moreover, dietary GlcCer significantly suppressed the production of cytokines by the intestinal mucosa 7 .…”

Section: Introductionmentioning

confidence: 93%

Section: Animals and Dietmentioning

confidence: 99%

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Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

et al. 2017

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“…Our current understanding is that food GlcCer is degraded to ceramide and further metabolized to sphingoid bases in the intestine. GlcCer isolated from food plants has recently been studied 20,21 and is used for health foods and cosmetics. The food plant sphingoid bases have also been studied, and d18:2 and t18:1 sphingoids have been demonstrated to bind peroxisome proliferator-activated receptor PPAR γ, thereby up-regulating de novo ceramide synthesis of very long-chain fatty acids in differentiated keratinocytes 17,22 .…”

Section: Introductionmentioning

confidence: 99%

Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway

et al. 2018

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Sphingoid base in pineapple glucosylceramide suppresses experimental allergy by binding leukocyte mono‐immunoglobulin‐like receptor 3

Takemura

Ohto²,

Kuwahara³

et al. 2021

J Sci Food Agric

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BACKGROUND The increase in patients suffering from type I hypersensitivity, including hay fever and food allergy, is a serious public health issue around the world. Recent studies have focused on allergy prevention by food factors with fewer side effects. The purpose of this study was to evaluate the effect of dietary glucosylceramide from pineapples (P‐GlcCer) on type I hypersensitivity and elucidate mechanisms. RESULTS Oral administration of P‐GlcCer inhibited ear edema in passive cutaneous anaphylaxis reaction. In a Caco‐2/RBL‐2H3 co‐culture system, P‐GlcCer inhibited β‐hexosaminidase release from RBL‐2H3 cells. The direct treatment of P‐GlcCer on RBL‐2H3 did not affect β‐hexosaminidase release, but sphingoid base moiety of P‐GlcCer did. These results predicted that sphingoid base, a metabolite of P‐GlcCer, through the intestine inhibited type I hypersensitivity by inhibiting mast cell degranulation. In addition, the inhibitory effects of P‐GlcCer on ear edema and degranulation of RBL‐2H3 cells were canceled by pretreatment of leukocyte mono‐immunoglobulin‐like receptor 3 (LMIR3)‐Fc, which can block LMIR3‐mediated inhibitory signals. CONCLUSION It was demonstrated that a sphingoid base, one of the metabolites of P‐GlcCer, may inhibit mast cell degranulation by binding to LMIR3. The oral administration of P‐GlcCer is a novel and attractive food factor that acts directly on mast cells to suppress allergy. © 2021 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice

Cited by 39 publications

References 25 publications

Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

Effects of Dietary Plant-origin Glucosylceramide on Colon Cytokine Contents in DMH-treated Mice

Konjac Ceramide (kCer) Regulates NGF-Induced Neurite Outgrowth via the Sema3A Signaling Pathway

Sphingoid base in pineapple glucosylceramide suppresses experimental allergy by binding leukocyte mono‐immunoglobulin‐like receptor 3

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