Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs

LeBlanc, Casey J.; Horohov, David W.; Bauer, John E.; Hosgood, Giselle; Mauldin, Glenna E.

doi:10.2460/ajvr.69.4.486

Cited by 64 publications

(47 citation statements)

References 27 publications

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“…Through the use of experimental models of inflammation, it was possible to observe that the eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA) derived from omega-3 essential fatty acids seem to present anti-inflammatory properties (Chapkin et al, 2009;Danno et al, 1993;Lau et al, 1993;LeBlanc et al, 2008;Nauroth et al, 2010;Raederstorff et al, 1996;Saw et al, 2010;Simopoulos, 2002;Weldon et al, 2007). The mechanisms by which such lipid substances exert their anti-inflammatory action are still a matter of controversy, but it seems likely that oxygenated metabolites derived from DHA and EPA identified and named as resolvins, protectins, and macrophage mediator in resolving inflammation (maresins) are responsible for such effects (Arita et al, 2005a;Bannenberg et al, 2005;Kohli and Levy, 2009;Kusunoki et al, 1992;Serhan et al, 2008;Serhan et al, 2002;Serhan et al, 2009).…”

Section: Epa-and Dha-derived Mediatorsmentioning

confidence: 99%

EPA- and DHA-derived resolvins' actions in inflammatory bowel disease

Schwanke¹,

Marcon²,

Bento³

et al. 2016

European Journal of Pharmacology

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Inflammatory bowel diseases are chronic diseases divided into two major forms, ulcerative colitis and Crohn's disease, which are both associated with a chronic inflammatory condition of the gastrointestinal tract. Recent studies have shown that the resolution of inflammatory conditions is a biosynthetically active process where new pro-resolution lipid mediators derived from omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), such as E- and D-series resolvins, protectins, and macrophage mediator in resolving inflammation (maresins), have potent anti-inflammatory activity and serve as specialised mediators that play an important role in the resolution of inflammation. Recent studies have also shown the role of resolvins in referred hyperalgesia associated with different inflammatory processes, such as the visceral pain caused by inflammatory bowel disease. There are many reports describing the principal effects of EPA- and DHA-derived mediators in experimental models of inflammatory bowel diseases. This review focuses on the recent studies on the important role played by pro-resolution lipid mediators in controlling the inflammatory process associated with inflammatory bowel diseases.

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Section: Epa-and Dha-derived Mediatorsmentioning

confidence: 99%

EPA- and DHA-derived resolvins' actions in inflammatory bowel disease

Schwanke¹,

Marcon²,

Bento³

et al. 2016

European Journal of Pharmacology

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“…Furthermore, 21 days of supplementation may not be sufficient to detect this change. In a study of normal dogs undergoing a combination of EPA and DHA dietary supplementation over 12 weeks, decreased inflammatory cytokine activity was documented [7]. Further support can be found in a recent study where combined EPA and DHA dietary supplementation over 56 days also augmented plasma PUFA concentrations but decreased concentration of synovial degradative enzymes in dogs with inflammatory joint disease [8].…”

Section: Discussionmentioning

confidence: 94%

Polyunsaturated Fatty Acid Dietary Supplementation Induces Lipid Peroxidation in Normal Dogs

Walters

Hackett

Ogilvie

et al. 2010

Veterinary Medicine International

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Polyunsaturated fatty acids (PUFAs) have anti-inflammatory effects at low concentrations; however increased dietary consumption may conversely increase susceptibility to oxidation by free radicals. The objective of this study was to determine the effects of PUFAs on selective oxidative injury and inflammatory biomarkers in canine urine and serum. Dogs (n = 54) consumed a diet supplemented with 0.5% conjugated linoleic acid/dry matter, 1.0% conjugated linoleic acid/dry matter, or 200 mg/kg docosahexaenoic acid/eicosapentaenoic acid for 21 days. All dogs exhibited significantly increased plasma PUFA concentrations. All dogs had significant elevations in urinary F2a isoprostane concentration, though dogs consuming a diet containing 1.0% conjugated linoleic acid/dry matter had the highest increase (P = .0052). Reduced glutathione concentrations within erythrocytes decreased significantly in all three dietary treatment groups (P = .0108). Treatment with diets containing 1.0% conjugated linoleic acid/dry matter resulted in the greatest increase in oxidant injury. Caution should be exercised when supplementing PUFAs as some types may increase oxidation.

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“…While peripheral vision may be assessable clinically in a veterinary practice, assessing subtleties of color vision would likely prove elusive. Perhaps the suppressive medication most conducive to veterinary application is sulfasalazine [62,63], as has been documented for gorillas [14]. Monitoring can be extended to quarterly with sulfasalazine, a regimen more amenable to/acceptable in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Recognition and Breed Specificity of Canine Spondyloarthropathy

Rothschild¹,

Breit²

2016

J Spine

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Human diseases sometimes represented across phylogenetic lines. Their recognition is at times compromised by differential (between human and veterinary medicine) use of diagnostic terms. A major impetus to such change is recognition of additional treatment options that would not be considered for the replaced diagnosis/category. Canine syndesmophytes are recognized as identifier for spondyloarthropathy. This study examines the breed-specificity of those changes.The axial skeletons and peripheral joints (when available) of 1323 dogs, identified to breed, were examined for evidence of syndesmophytes and sacroiliac joint disease.Syndesmophytes were found in 315 of 1323 axial skeletons examined, extremely common in Boxer and German Shephard; rare, in Beagle, Chihauahua, Dachshund, Maltese and Pug. First noted at 2 years of age, its prevalence increased geometrically over the next 13 years. All affected individuals weighed more than 2 kilograms and prevalence increased geometrically through 39.9 kilograms. Spondyloarthropathy was present in 17.3% of brachycephalic, contrasted with 35.0% of mesticephalic dogs [Chi square = 16.972, p < 0.0001].Presence of syndesmophytes identified the underlying arthritis as spondyloarthropathy, not osteoarthritis. Recognition of the vertebral findings as characteristic of this inflammatory arthritis affords an opportunity for controlling the disease process and improving quality of life of the afflicted dog.

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Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs

Cited by 64 publications

References 27 publications

EPA- and DHA-derived resolvins' actions in inflammatory bowel disease

EPA- and DHA-derived resolvins' actions in inflammatory bowel disease

Polyunsaturated Fatty Acid Dietary Supplementation Induces Lipid Peroxidation in Normal Dogs

Recognition and Breed Specificity of Canine Spondyloarthropathy

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