Effects of different malnutrition techniques on the behavior of rats tested in the elevated T-maze

Hernandes, Andréa da Silva; Françolin-Silva, Ana Laura; Valadares, Camila Tavares; Fukuda, Marisa Tomoe Hebihara; Almeida, Sebastião de Sousa

doi:10.1016/j.bbr.2005.03.008

Cited by 34 publications

(16 citation statements)

References 33 publications

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“…In fact, similar behavior was reported in prenatally protein‐malnourished rats (da Silva Hernandes et al. ; Francolin‐Silva et al. ; Mokler et al.…”

Section: Discussionsupporting

confidence: 81%

Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring

2014

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IntroductionThe ketogenic diet (KD) has seen an increase in popularity for clinical and non-clinical purposes, leading to rise in concern about the diet's impact on following generations. The KD is known to have a neurological effect, suggesting that exposure to it during prenatal brain development may alter neuro-anatomy. Studies have also indicated that the KD has an anti-depressant effect on the consumer. However, it is unclear whether any neuro-anatomical and/or behavioral changes would occur in the offspring and persist into adulthood.MethodsTo fill this knowledge gap we assessed the brain morphology and behavior of 8-week-old young-adult CD-1 mice, who were exposed to the KD in utero, and were fed only a standard-diet (SD) in postnatal life. Standardized neuro-behavior tests included the Open-Field, Forced-Swim, and Exercise Wheel tests, and were followed by post-mortem Magnetic Resonance Imaging (MRI) to assess brain anatomy.ResultsThe adult KD offspring exhibit reduced susceptibility to anxiety and depression, and elevated physical activity level when compared with controls exposed to the SD both in utero and postnatally. Many neuro-anatomical differences exist between the KD offspring and controls, including, for example, a cerebellar volumetric enlargement by 4.8%, a hypothalamic reduction by 1.39%, and a corpus callosum reduction by 4.77%, as computed relative to total brain volume.ConclusionsThese results suggest that prenatal exposure to the KD programs the offspring neuro-anatomy and influences their behavior in adulthood.

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“…In fact, similar behavior was reported in prenatally protein‐malnourished rats (da Silva Hernandes et al. ; Francolin‐Silva et al. ; Mokler et al.…”

Section: Discussionsupporting

confidence: 81%

Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring

2014

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“…Impaired growth of rats submitted to low-protein diets is a well-established result in studies by our group (Fukuda et al 2002, Da Silva Hernandes et al 2005. Nutritional recovery imposed to the animals from day 50 to 70 was not sufficient for the malnourished animals to reach the weight of the control.…”

Section: Discussionmentioning

confidence: 93%

“…Protein and protein -calorie malnutrition during the early stages of life are known to produce impairments in brain development altering neuroanatomical, neurochemical and neurophysiological and/or functional parameters of the central nervous system (CNS) in both animal and humans (Bedi 1991, Lukoyanov and Andrade 2000, Morgane et al 2002, Rotta et al 2003, Alamy et al 2005, Da Silva Hernandes et al 2005.…”

Section: Introductionmentioning

confidence: 99%

Effects of early protein malnutrition and scopolamine on learning and memory in the Morris water maze

Fukuda

Françolin-Silva

Hernandes

et al. 2007

Nutritional Neuroscience

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The present study investigated the effects of early protein malnutrition on the spatial learning and memory processes. The consequences of malnutrition for the cholinergic system were evaluated by comparing the performance of malnourished and control animals in the Morris water maze after treatment with scopolamine. The learning test consisted of placing the animal in the maze to escape to a submerged platform with 12 trials per day for two consecutive days. After 24 trials, the platform was removed, the rats were placed in the maze and the time spent by them in each quadrant was recorded. After 28 days the animals were tested in a single trial to verify the retention of the spatial information. In the first Experiment, scopolamine (0.0, 0.2, 0.4 and 0.6 mg/kg per ml. i.p.) was administered 20 min before the experimental sessions. In the second experiment, a dose of 0.6 mg/kg was administered after the sessions, during the period in which learning consolidation occurs. In the first experiment, there was a significant effect of the drug, with scopolamine impairing, learning in both nutritional conditions. In the saline condition, control animals presented a better performance when compared with malnourished animals. However, 28 days later, both groups increased their latencies. With 0.2 and 0.4 mg/kg of scopolamine, the performance of both nutritional groups was similar and with 0.6 mg/kg malnourished animals performed better than controls. In the second experiment, malnourished animals were also less reactive to the effects of scopolamine, resulting in lower impairments as compared to control animals. These data suggest long-term changes in learning and memory as the result of changes produced by protein malnutrition in the cholinergic neurotransmitter system.

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“…All of these techniques are efficient to produce significant effects both on physical and behavioral developments in rats, as demonstrated by Hernandes and her co-workers [39]. …”

Section: Animal Studiesmentioning

confidence: 99%

Early Postnatal Protein-Calorie Malnutrition and Cognition: A Review of Human and Animal Studies

Laus

Vales

Costa

et al. 2011

IJERPH

122

101

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Malnutrition continues to be recognized as the most common and serious form of children’s dietary disease in the developing countries and is one of the principal factors affecting brain development. The purpose of this paper is to review human and animal studies relating malnutrition to cognitive development, focusing in correlational and interventional data, and to provide a discussion of possible mechanisms by which malnutrition affects cognition.

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Effects of different malnutrition techniques on the behavior of rats tested in the elevated T-maze

Cited by 34 publications

References 33 publications

Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring

Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring

Effects of early protein malnutrition and scopolamine on learning and memory in the Morris water maze

Early Postnatal Protein-Calorie Malnutrition and Cognition: A Review of Human and Animal Studies

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