Effects of different physical training protocols on ventricular oxidative stress parameters in infarction-induced rats

Pinho, Cleber A.; Tromm, Camila Baumer; Tavares, Ângela Maria Vicente; Silva, Luciano Acordi da; Souza, Cláudio Teodoro de; Benetti, Magnus; Pinho, Ricardo Aurino de

doi:10.1016/j.lfs.2012.01.018

Cited by 31 publications

(19 citation statements)

References 49 publications

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“…This effect probably occurs due to a significant improvement in cell detoxification due to the improvement in activity of antioxidant enzymes, as shown above and which has been pointed out in previous studies [39], as well as a redox status improvement in trained animals [40]. As mentioned before, some of the cardiovascular diseases are induced or involved with oxidative stress.…”

Section: Discussionsupporting

confidence: 55%

Can fish oil supplementation and physical training improve oxidative metabolism in aged rat hearts?

et al. 2015

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Section: Discussionsupporting

confidence: 55%

Can fish oil supplementation and physical training improve oxidative metabolism in aged rat hearts?

et al. 2015

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“…It is possible that this positive effect is due to an improvement in the antioxidant defense system, also observed in the present study. Several studies conducted in our laboratory have shown that, in a disease, physical training can improve the parameters of oxidative stress by stimulating the antioxidant system in various tissues such as muscle (Pinho et al, 2006), lung (Menegali et al, 2009), heart (Pinho et al, 2012) and kidney (Coelho et al, 2010), reducing the production of oxidants and improving the resistance of the tissue against the action of free radicals.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

et al. 2012

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“…Several potential candidates have been previously evaluated in the myocardium, as follows: antioxidant defense (Pinho et al, 2012); increased angiogenesis (Leosco et al, 2012); favorable inflammatory status (Beavers, Brinkley, & Nicklas, 2010). There is a growing body of evidence showing that AET is associated with an beneficial modulation of programmed cell death (apoptosis) of the cardiomyocytes (Huang et al, 2012;Siu, Bryner, Martyn, & Alway, 2004).…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue

Sant’Ana¹,

Serra²,

Silva³

et al. 2014

Motriz: rev. educ. fis.

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Abstract-This study evaluated modulators of apoptosis in the myocardium of rats subjected to exercise training. Rats were assigned to non-trained and exercise-trained groups, respectively. The animals ran for 1 h per day, 6 times per week and, for a total of 13 weeks. The left ventricle was processed for analysis of gene and protein anti-(Bcl-2, c-IAP1, c-IAP2, Survivin, ILK, Akt and pAkt) and pro-(Bad) apoptotic expression by real-time PCR (except for Akt and pAkt) and Western blot, respectively. The Bad mRNA (p<0.05), but not the protein expression (p = 0.19), was significantly lower after training. The exercise training significantly increased the gene and protein expression for all anti-apoptotic factors. However, a significant change in the c-IAP2 was seen only for gene expression (p<0.05). The present findings indicate that exercise can create a favorable milieu for the survival of cardiomyocytes when apoptosis is increased. Keywords: apoptosis, exercise training, myocardialResumo-"Treinamento físico aeróbico induz ambiente anti-apoptótico em tecido miocárdico." Este estudo analisou moduladores de apoptose no miocárdio de ratos submetidos a treinamento físico. Os ratos foram distribuídos nos seguintes grupos, respectivamente: não treinados; treinados. Os animais realizaram exercício em esteira (60 min./dia; 6 x semana) por 13 semanas. O ventrículo esquerdo foi processado para análise da expressão gênica e protéica de fatores anti-apoptóticos (Bcl-2, c-IAP1, c-IAP2, Survivina, ILK, Akt e pAkt) e pro-apoptóticos (Bad) por PCR em tempo real (exceto Akt e pAkt) e Western blot, respectivamente. O teor de RNAm da Bad (p<0,05) foi significativamente reduzido após treinamento. Porém, a expressão protéica da Bad não foi diferente entre os grupos. A expressão gênica e proteica de todos os fatores anti-apoptóticos foi significativamente aumentada com o treinamento. A exceção foi para c-IAP2, que aumentou somente em nível transcripcional (p<0,05). Os achados deste estudo indicam que o exercício cria um ambiente favorável para sobrevivência dos cardiomiócitos a apoptose. Palavras-chave: apoptose, treinamento físico, miocárdioResumen-"La práctica de ejercicio aeróbico induce un ambiente anti-apoptótico en tejido miocárdico." El estudio analizó moduladores de la apoptosis en el miocardio de ratas entrenadas físicamente. Las ratas se dividieron en no entrenado y entrenadas. Los animales se ha ejecutado (60 por día x 6 semanas) a las 13 semanas. El ventrículo izquierdo se procesan para el análisis de la expresión de sus genes y proteínas que inhiben (Bcl-2, c-IAP1, c-IAP2, survivina, ILK, Akt y pAkt) y causa (Bad) de la apoptosis por PCR en tiempo real (excepto Akt y pAkt) y Western blot. El nivel de ARNm de Bad (p<0,05) se redujo después de la entrenamiento, pero no era diferente de proteína. La expresión de los inhibidores de la apoptosis fue significativamente mayor con la entrenamiento. La excepción fue para c-IAP2, que aumentó sólo en el nivel transcripcional (p<0,05). Los resultados de este estudio indican que el eje...

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Effects of different physical training protocols on ventricular oxidative stress parameters in infarction-induced rats

Cited by 31 publications

References 49 publications

Can fish oil supplementation and physical training improve oxidative metabolism in aged rat hearts?

Can fish oil supplementation and physical training improve oxidative metabolism in aged rat hearts?

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease

Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue

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