Effects of early-life malnutrition on neurodevelopment and neuropsychiatric disorders and the potential mechanisms

Yan, Xintian; Zhao, Xinzhi; Li, Juxue; He, Lin; Xu, Mingqing

doi:10.1016/j.pnpbp.2017.12.016

Cited by 52 publications

(39 citation statements)

References 173 publications

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“…According to previous literatures, prenatal malnutrition might have an impact on genetic selection, which would increase the chance of obtaining de novo genetic mutations in germ cells and transmit to the offspring if the starvation occurs before fertilization or elevate the probability of passing on the alleles of neuropsychiatric disorders to the next generation when pregnant women under nutritional stress 38,39 . In addition, transcriptome analysis using mouse model under prenatal nutritional deficient environment revealed altered gene expression profile and discovered 15 key genes related to autism and schizophrenia [40][41][42] .…”

Section: Discussionmentioning

confidence: 99%

A Chinese multicenter retrospective study of isolated increased nuchal translucency associated chromosome anomaly and prenatal diagnostic suggestions

Jin

Wang

Zhang

et al. 2021

Sci Rep

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Extensive researches involving fetuses with multiple ultrasound anomalies have been conducted over the years, but only few were focused on the isolated increased nuchal translucency (NT). On top of that, these limited number of researches were all designed as single-arm studies and the control group was missing. In this study, we conducted a multicenter, retrospective study using amniotic fluid samples collected from 1197 pregnant women having fetuses with isolated increased NT (INT group) or normal NT values (NNT group). Copy number variation sequencing (CNV-seq) was performed to determine their chromosome status and pathogenic variations were validated using SNP array. Overall, 59 chromosome aneuploidies, 34 pathogenic CNVs and 23 copy number variants of unknown significance (VOUS CNVs) were discovered. the INT group had a significantly higher proportion of aneuploidy (19.44%) and pathogenic CNV (8.33%) than the control group (3.49% and 2.30% respectively), and 88.89% of the pathogenic CNVs were related to heart defects. Additionally, more male fetuses were presented in the INT group (68.51%), but they did not have a higher risk (Relative Risk = 1.03) of carrying pathogenic chromosome variations than female fetuses. Our results demonstrated that fetuses with isolated increased NT had a distinct pattern of chromosome abnormality and majority of detected pathogenic CNVs could be linked to the congenital heart disease. Furthermore, because a considerable proportion of pathogenic CNVs were detected, we strongly recommend to perform a joint test of karyotyping and CNV analysis in prenatal diagnosis for fetuses with isolated increased NT in order to decrease the incident of missed diagnosis.

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Section: Discussionmentioning

confidence: 99%

A Chinese multicenter retrospective study of isolated increased nuchal translucency associated chromosome anomaly and prenatal diagnostic suggestions

Jin

Wang

Zhang

et al. 2021

Sci Rep

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“…Nowadays, several studies showing that food is not only useful for providing energy for bodily functions [35], but it can also prevent or moderate several diseases and a proper diet can improve both physical and mental health [4,5,25,36,37,38]. Omega-3 LC-PUFA supplementation has been shown to produce beneficial effects in children with ADHD, as summarized by two recent meta-analyses, although some conflicting results have been also reported [12,13,14,15].…”

Section: Discussionmentioning

confidence: 99%

“…There is a growing evidence that several mental disorders, although they show an underlying genetic predisposition [1], are probably the product of an interplay between genetic susceptibility and environmental factors [2], of which inadequate nutrition may be a component [3,4]. Among the nutrients that have been consistently shown to be related to mental health and to different psychiatric disorders, mention must be made of omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Omega-3 Long-Chain Polyunsaturated Fatty Acids Intake in Children with Attention Deficit and Hyperactivity Disorder

2019

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Omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) play a central role in neuronal growth and in the development of the human brain, and a deficiency of these substances has been reported in children with attention deficit hyperactive disorder (ADHD). In this regard, supplementation with omega-3 polyunsaturated fatty acids is used as adjuvant therapy in ADHD. Seafood, particularly fish, and some types of nuts are the main dietary sources of such fatty acids in the Spanish diet. In order to assess the effect of the intake of common foods containing high amounts of omega-3 polyunsaturated fatty acids, a food frequency questionnaire was administered to parents of children with ADHD (N = 48) and to parents of normally developing children (control group) (N = 87), and the intake of dietary omega-3 LC-PUFA, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), was estimated. Children with ADHD consumed fatty fish, lean fish, mollusks, crustaceans, and chicken eggs significantly less often (p < 0.05) than children in the control group. The estimated daily omega-3 LC-PUFA intake (EPA + DHA) was significantly below that recommended by the public health agencies in both groups, and was significantly lower in children with ADHD (p < 0.05, Cohen’s d = 0.45) compared to normally developing children. Dietary intervention to increase the consumption of fish and seafood is strongly advised and it is especially warranted in children with ADHD, since it could contribute to improve the symptoms of ADHD.

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“…Apart from extreme undernutrition, moderate caloric and nutrient restriction during pregnancy (self-imposed maternal dieting or teenage pregnancy) is common in developing and developed countries [ 266 ]. The consistently decreased exposure to proper quantity and quality of food during pregnancy can lead to irreversible changes in crucial body systems such as the CNS [ 267 ], cardiovascular [ 268 ], haemopoietic [ 269 ] and immune system [ 270 ] of the developing fetus.…”

Section: Early Life Microbiota: Another Component In the Vicious Cmentioning

confidence: 99%

Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis

et al. 2021

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Microbes colonize the human body during the first moments of life and coexist with the host throughout the lifespan. Intestinal microbiota and their metabolites aid in the programming of important bodily systems such as the immune and the central nervous system during critical temporal windows of development, with possible structural and functional implications throughout the lifespan. These critical developmental windows perinatally (during the first 1000 days) are susceptible timepoints for insults that can endure long lasting effects on the microbiota-gut-brain axis. Environmental and parental factors like host genetics, mental health, nutrition, delivery and feeding mode, exposure to antibiotics, immune activation and microbiota composition antenatally, are all factors that are able to modulate the microbiota composition of mother and infant and may thus regulate important bodily functions. Among all these factors, early life nutrition plays a pivotal role in perinatal programming and in the modulation of offspring microbiota from birth throughout lifespan. This review aims to present current data on the impact of early life nutrition and microbiota priming of important bodily systems and all the factors influencing the microbial coexistence with the host during early life development.

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Effects of early-life malnutrition on neurodevelopment and neuropsychiatric disorders and the potential mechanisms

Cited by 52 publications

References 173 publications

A Chinese multicenter retrospective study of isolated increased nuchal translucency associated chromosome anomaly and prenatal diagnostic suggestions

A Chinese multicenter retrospective study of isolated increased nuchal translucency associated chromosome anomaly and prenatal diagnostic suggestions

Omega-3 Long-Chain Polyunsaturated Fatty Acids Intake in Children with Attention Deficit and Hyperactivity Disorder

Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis

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