Effects of Early Statin Treatment on Symptomatic Heart Failure and Ischemic Events After Acute Myocardial Infarction in Japanese

Sakamoto, Tomohiro; Kojima, Sunao; Ogawa, Hisao; Shimomura, Hideki; Kimura, Kazuo; Ogata, Yasuhiro; Sakaino, Naritsugu; Kitagawa, Akira

doi:10.1016/j.amjcard.2005.11.031

Cited by 92 publications

(51 citation statements)

References 11 publications

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“…14 Briefly, between February 2002 and September 2004, a total of 486 consecutive eligible AMI patients who were admitted to 54 medical centers throughout Japan were recruited. Serum total cholesterol (TC) concentrations were required to be 180-240 mg/dl.…”

Section: Methodsmentioning

confidence: 99%

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

Sakamoto

Kojima

Ogawa

et al. 2007

Circ J

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Section: Methodsmentioning

confidence: 99%

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

Sakamoto

Kojima

Ogawa

et al. 2007

Circ J

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“…MUSASHI-AMI was conducted in 54 hospitals in 28 prefectures in Japan and included 486 consecutive patients with AMI. 42 Within 96 h of symptom onset, patients were assigned to receive conventional therapy without statins or plus open-label statin treatment with one of the following statins available in Japan at that time: pravastatin, atorvastatin, simvastatin, fluvastatin or pitavastatin. Almost half of the study patients were treated with pravastatin and two-thirds with standard statins.…”

Section: Lessons From the Musashi Project A Japanese Secondary Prevementioning

confidence: 99%

"Just Make It Lower" Is an Alternative Strategy of Lipid-Lowering Therapy With Statins in Japanese Patients - LDL-Cholesterol: The Lower, the Better; Is It True for Asians? (Con) -

Sakamoto

Ogawa

2010

Circ J

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“…The effect of statins in AMI patients with left ventricular dysfunction according to the level of hs-CRP has not been reported. 24) To our knowledge, the present study is the fi rst to show that statin therapy can improve the long-term clinical outcomes in AMI patients with LV systolic dysfunction who were prone to high inflammatory status. The findings suggest that statin therapy was benefi cial in the group of patients with baseline hs-CRP levels ≥ 2.0 mg/L.…”

Section: A B Discussionmentioning

confidence: 99%

Effect of Statin Treatment in Patients With Acute Myocardial Infarction and Left Ventricular Systolic Dysfunction According to the Level of High-Sensitivity C-Reactive Protein

et al. 2014

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SummaryThe effects of statins on the prognosis of patients with left ventricular (LV) systolic dysfunction remain controversial. The aim of this study was to assess the effect of statin treatment on clinical outcomes in acute myocardial infarction (AMI) patients with LV systolic dysfunction. A total of 5,119 AMI patients with LV ejection fraction less than 50% on the initial echocardiogram were analyzed in the Korean Acute Myocardial Infarction Registry. The study population was divided into 4 groups according to the level of high sensitivity C-reactive protein (hs-CRP) and statin treatment: low hs-CRP (hs-CRP ≤ 2.0 mg/L) and high hs-CRP (hs-CRP > 2 mg/L) with or without statin therapy. We evaluated the incidence of major adverse cardiac events (MACEs) including cardiac death, reinfarction, target lesion revascularization, and coronary artery bypass grafting during a 12-month period in each group. Statin therapy did not signifi cantly prevent the MACEs in the low hs-CRP groups (with statin: 10.1% versus without statin: 12.0%, P = 0.249). In the high hs-CRP groups, however, the incidence of MACEs was signifi cantly decreased with statin treatment (with statin: 11.3%, without statin: 20.8%, P < 0.001). These fi ndings were consistently observed in all subgroups of the high-hs CRP group, including the subgroup with an LV ejection fraction less than 40%. In a multivariable logistic regression analysis of the high hs-CRP group, lack of statin therapy was a signifi cant predictor of MACE incidence (odds ratio: 1.573, 95% confi dence interval: 1.079-2.293, P = 0.018). The statin treatment was associated with better outcome in AMI and LV dysfunction patients with hs-CRP ≥ 2 mg/dL. (Int Heart J 2014; 55: 106-112)

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Effects of Early Statin Treatment on Symptomatic Heart Failure and Ischemic Events After Acute Myocardial Infarction in Japanese

Cited by 92 publications

References 11 publications

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

Usefulness of Hydrophilic vs Lipophilic Statins After Acute Myocardial Infarction Subanalysis of MUSASHI-AMI

"Just Make It Lower" Is an Alternative Strategy of Lipid-Lowering Therapy With Statins in Japanese Patients - LDL-Cholesterol: The Lower, the Better; Is It True for Asians? (Con) -

Effect of Statin Treatment in Patients With Acute Myocardial Infarction and Left Ventricular Systolic Dysfunction According to the Level of High-Sensitivity C-Reactive Protein

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