Effects of eicosapentaenoic acid and docosahexaenoic acid on responses of LPS-stimulated intestinal B lymphocytes from broiler chickens studied in vitro

Wang, Yi Bing; Yang, Xiao; Qin, Ding; Yu, Feng; Guo, Yu; Yao, Jun

doi:10.1007/s00217-011-1554-1

Cited by 6 publications

(7 citation statements)

References 34 publications

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“…In addition, at 6 weeks of age, heavier broiler weight was recorded in groups fed 2.5% flaxseed oil when compared with a standard control diet containing 2.5% tallow ( Carragher et al., 2016 ). Wang et al. (2011) argued that the effect of n-3 PUFA in broiler diet was dependent on their dietary level since low levels of dietary fish oil are more effective than high levels in improving performance and feed gain.…”

Section: Resultsmentioning

confidence: 99%

Changing dietary n-6:n-3 ratio using different oil sources affects performance, behavior, cytokines mRNA expression and meat fatty acid profile of broiler chickens

Ibrahim¹,

Elsayed²,

Khater³

et al. 2018

Animal Nutrition

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Typical formulated broiler diets are deficient in n-3 poly-unsaturated fatty acids (PUFA) due to widening n-6:n-3 PUFA ratio which could greatly affect performance, immune system of birds and, more importantly, meat quality. This study was conducted to evaluate the effect of modifying dietary n-6:n-3 PUFA ratio from plant and animal oil sources on performance, behavior, cytokine mRNA expression, antioxidative status and meat fatty acid profile of broiler chickens. Birds (n = 420) were fed 7 diets enriched with different dietary oil sources and ratios as follows: sunflower oil in control diet (C); fish oil (FO); 1:1 ratio of sunflower oil to FO (C1FO1); 3:1 ratio of sunflower oil to fish oil (C3FO1); linseed oil (LO); 1:1 ratio of sunflower oil to linseed oil (C1LO1); 3:1 ratio of sunflower oil to linseed oil (C3LO1), resulting in dietary n-6:n-3 ratios of approximately 40:1, 1.5:1, 4:1, 8:1, 1:1, 2.5:1 and 5:1, respectively. The best final body weight, feed conversion ratio as well as protein efficiency ratio of broilers were recorded in the C1FO1 and C1LO1 groups. Compared with the control group, the dressing percentage and breast and thigh yield were highest in the C1FO1 and C1LO1 groups. Narrowing the dietary n-6:n-3 ratio increased (P < 0.05) n-3 PUFA content of breast meat. Moreover, the breast meat contents of eicosapentaenoic acid and docosahexaenoic acid increased (P < 0.05) with increasing dietary FO whereas α-linolenic acid content was higher with LO supplementation. Also, enriching the diets with n-3 PUFA from FO and LO clearly decreased (P < 0.05) serum total cholesterol, triglycerides and very low-density lipoproteins and enhanced antioxidative status. The feeding frequency was decreased (P < 0.05) in the C1FO1 and C1LO1 groups. Likewise, n-3 PUFA-enriched diets enhanced the frequency of preening, wing flapping and flightiness. Animal oil source addition, compared to plant oil, to broiler diets enhanced the relative mRNA expression of interferon gamma, interleukin-1 beta, interleukin-2 and interleukin-6 genes, especially at low n-6:n-3 ratios. This study has clearly shown that narrowing n-6:n-3 ratio through the addition of FO or LO improved performance and immune response of broilers and resulted in healthy chicken meat, enriched with long chain n-3 PUFA.

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Section: Resultsmentioning

confidence: 99%

Changing dietary n-6:n-3 ratio using different oil sources affects performance, behavior, cytokines mRNA expression and meat fatty acid profile of broiler chickens

Ibrahim¹,

Elsayed²,

Khater³

et al. 2018

Animal Nutrition

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“…The improved performance of broilers fed a diet containing 2% FO might be due to the high levels of n-3 PUFA (e.g., EPA or DHA) present in FO, that have been shown to improve both the immune status and nutrient digestibility in broilers [6]. Interestingly, low levels of dietary FO (such as 2%) have been demonstrated as being more effective than high levels of FO on improving performance [16]. The improved performance by dietary n-3 PUFA supplementation in broilers is also due to the narrowing dietary n-6/n-3 PUFA ratio (close to 4:1 or 2.5:1) and increasing the n-3 PUFA level that could effectively improve immune responses [17].…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Fatty Acids from Different Sources on Growth Performance, Meat Quality, Muscle Fatty Acid Deposition, and Antioxidant Capacity in Broilers

Long

Liu

2020

Animals

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Simple Summary:The findings in the current study reveal that dietary fish oil or a combination of linseed oil and microalgae could be effective in improving growth performance, carcass traits, muscle fatty acid deposition, and antioxidant capacity in broilers compared with traditional soybean oil in broilers.Abstract: This study aimed to investigate the efficiency of dietary fatty acids from various sources on growth performance, meat quality, muscle fatty acid deposition and antioxidant capacity in broilers. 126 Arbor Acres broilers (1 d-old, initial body weight of 45.5 ± 0.72 g) were randomly assigned to three treatments with seven cages per treatment and six broilers per cage. The dietary treatments included:(1) corn-soybean meal basal diet containing 3% soybean oil (control diet, CTL); (2) basal diet + 1% microalgae + 1% linseed oil + 1% soybean oil (ML); (3) basal diet + 2% fish oil + 1% soybean oil (FS). The trial consisted of phase 1 (day 1 to 21) and 2 (day 22 to 42). Compared with CTL, broilers fed ML or FS diet showed improved (p < 0.05) average daily gain in phase 1, 2, and overall (day 1 to 42), as well as a decreased (p < 0.05) feed conversion ratio in phase 1 and overall. On day 42, broilers supplemented with FS diet showed increased (p ≤ 0.05) the relative weights of pancreas and liver, as well as higher (p < 0.05) redness value in breast and thigh muscle compared with CTL. Broilers offered ML or FS diet had lower (p < 0.05) the relative weight of abdominal fat and total serum cholesterol content in phase 1, and increased (p < 0.05) contents of serum glucose, n-3 polyunsaturated fatty acids (PUFA), eicosacagetaenoic acid, docosahexaenoic acid, glutathione peroxidase, superoxide dismutase and total antioxidant capacity, as well as lower (p < 0.05) concentrations of malondialdehyde, n-6 PUFA, and n-6/n-3 PUFA ratio in breast and thigh muscle compared with CTL. This research indicates that diets supplemented with fish oil or a combination of microalgae and linseed oil experience improved performance, antioxidant capacities and n-3 PUFA profile in muscle of broilers compared with traditional soybean oil supplemented diets Animals 2020, 10, 508 2 of 13 docosahexaenoic acid (DHA, C22:6n-3), eicosacagetaenoic acid (EPA, C20:5n-3), and alpha-linolenic acid (ALA, C18:3n-3)-as well as an increased ratio of PUFA to saturated fatty acid ratio (PUFA/SFA ratio) and n-3/n-6 PUFA ratio-are necessary and beneficial for broilers and human health [1]. However, the intake of n-3 PUFA in the average human diet is low and the conversion of ALA to EPA and DHA in the human body is also low [2]. Therefore, scientists have recently shown more interest in producing poultry meat products enriched with n-3 PUFA for human consumption [3].The fatty acid composition in the breast and thigh muscles of animals is highly related to the fatty acids in the diet fed to animals [4], so providing animals with diets enriched in n-3 PUFA can be the most practical way to manipulate the n-3 PUFA profiles of meat [5]. Previous studies have sh...

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“…The results of an in vitro study (Babu et al, 2009) showed that uptake of n-3 PUFAs, i.e., α-linolenic acid (ALA) and DHA, increased clearance of S. enterica (measured by the plating of sorted viable infected cells) by chicken macrophages (HD11 cells), with no effect on NO or O 2 À production by HD11 cells. Wang et al (2011) demonstrated that EPA and DHA inhibited the in vitro proliferation of lipopolysaccharide in LPS-stimulated B lymphocytes in chickens, as well as suppressing the ability of LPS-stimulated B cells to secrete IgA immunoglobulin.…”

Section: Male Female Broiler Breedersmentioning

confidence: 98%

The relationship between dietary fat sources and immune response in poultry and pigs: An updated review

2015

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Effects of eicosapentaenoic acid and docosahexaenoic acid on responses of LPS-stimulated intestinal B lymphocytes from broiler chickens studied in vitro

Cited by 6 publications

References 34 publications

Changing dietary n-6:n-3 ratio using different oil sources affects performance, behavior, cytokines mRNA expression and meat fatty acid profile of broiler chickens

Changing dietary n-6:n-3 ratio using different oil sources affects performance, behavior, cytokines mRNA expression and meat fatty acid profile of broiler chickens

Effects of Dietary Fatty Acids from Different Sources on Growth Performance, Meat Quality, Muscle Fatty Acid Deposition, and Antioxidant Capacity in Broilers

The relationship between dietary fat sources and immune response in poultry and pigs: An updated review

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