The relationship between dietary fat sources and immune response in poultry and pigs: An updated review

Świątkiewicz, Sylwester; Arczewska-Włosek, Anna; Józefiak, Damian

doi:10.1016/j.livsci.2015.07.017

Cited by 31 publications

(34 citation statements)

References 81 publications

(97 reference statements)

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“…Furthermore, it has been suggested that DHA promotes the production of pro-resolving cytokines from T helper lymphocytes and monocytes, via activation of the PPAR-gamma transcription factor; which finally contributes to adequate pro-resolving inflammatory responses that maintain a healthy status (Jaudszus et al, 2013 ). Moreover, it has been reported that the administration of DHA and/or EPA regulates the immune response in several animals such as cattle, goats, poultry, and pigs (Moreno-Indias et al, 2012 ; Bragaglio et al, 2015 ; Swiatkiewicz et al, 2015 ). Therefore, DHA and EPA could improve the efficacy of vaccines against inflammatory disorders.…”

Section: Relevant Characteristics Of Schizochytrium Sp mentioning

confidence: 99%

Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines

Ramos‐Vega¹,

Rosales‐Mendoza

Bañuelos-Hernández

et al. 2018

Front. Microbiol.

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Although oral subunit vaccines are highly relevant in the fight against widespread diseases, their high cost, safety and proper immunogenicity are attributes that have yet to be addressed in many cases and thus these limitations should be considered in the development of new oral vaccines. Prominent examples of new platforms proposed to address these limitations are plant cells and microalgae. Schizochytrium sp. constitutes an attractive expression host for vaccine production because of its high biosynthetic capacity, fast growth in low cost culture media, and the availability of processes for industrial scale production. In addition, whole Schizochytrium sp. cells may serve as delivery vectors; especially for oral vaccines since Schizochytrium sp. is safe for oral consumption, produces immunomodulatory compounds, and may provide bioencapsulation to the antigen, thus increasing its bioavailability. Remarkably, Schizochytrium sp. was recently used for the production of a highly immunoprotective influenza vaccine. Moreover, an efficient method for transient expression of antigens based on viral vectors and Schizochytrium sp. as host has been recently developed. In this review, the potential of Schizochytrium sp. in vaccinology is placed in perspective, with emphasis on its use as an attractive oral vaccination vehicle.

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Section: Relevant Characteristics Of Schizochytrium Sp mentioning

confidence: 99%

Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines

Ramos‐Vega¹,

Rosales‐Mendoza

Bañuelos-Hernández

et al. 2018

Front. Microbiol.

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“…Other studies have also indicated that serum white blood cell count and IL-2 concentration were increased at 7 days following IBD challenge in birds fed diets with 5.5% fish oil (Maroufyan et al, 2013). Dietary supplementation with rich sources of n-3 PUFAs, especially with fish oil, can have a beneficial, modulating influence on the immune system; specifically they appear to decrease acute and chronic inflammatory immune reactions and simultaneously to improve indices of specific immune response (Swiatkiewicz, Arczewska-Wlosek, & Jozefiak, 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary fat level and source on performance and immune system response of turkeys

Omidi

Mohit

Hossein-Zadeh

2019

Acta Sci. Anim. Sci.

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An experiment was conducted to determine effects of different levels and sources of fats in diets on growth performance, carcass characteristics and immune response of turkeys during four periods (0-21, 22 to 42, 43 to 63 and 64 to 70 days of age). A completely randomized design with five treatments, six replicates and eight B.U.T.6 turkey chickens per replicate was used. Treatments included: Control diet, diet containing 2.5% of soybean oil, diet containing 2.5% fat supplement, diet containing 5% soybean oil, diet containing 5% fat supplement. The results showed that using 5% of soybean oil increased average daily gain of turkeys (89.04 g) throughout the experimental period (0-70 days) compared with the control group (81.11 g; p < 0.05). Treatments containing 2.5 and 5% soybean oil improved feed conversion ratio compared to control group (p < 0.05). Soybean oil at the levels of 2.5 and 5% was led to higher spleen and bursa percentages compared to other treatments, respectively (p < 0.05). The level and source of dietary fat had not significant effect on antibody titer against Newcastle virus vaccine on 42 and 70 days of age (p > 0.05). It can be concluded that supplementing diet with 5% soybean oil improved the performance of turkeys.

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“…The immunomodulatory effect of dietary PUFA on broiler chickens has been extensively studied, but the results are inconsistent (Swiatkiewicz et al., 2015). Some studies indicated that the dietary administration of fish oil decreases the production of a more pro-inflammatory series of leukotrienes (Hall et al., 2007) and improves the indices of specific immune responses in growing chickens (Korver and Klasing, 1997), whereas others showed either adverse effects of fish oil on antibody production and lymphocyte proliferation (Fritsche et al., 1991) or no effects (Puthpongsiriporn and Scheideler, 2005).…”

Section: Introductionmentioning

confidence: 99%

Interactive effects of dietary lipids and vitamin E level on performance, blood eicosanoids, and response to mitogen stimulation in broiler chickens of different ages

et al. 2017

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The effects of the dietary polyunsaturated fatty acids (PUFA) n-6:n-3 ratio and vitamin E (vE) on the levels of pro-inflammatory eicosanoids, the incorporation of docosahexaenoic acid (DHA) and arachidonic acid (AA) into immune tissues, and changes in leukocyte population after phytohemagglutinin (PHA) challenge were investigated in broiler chickens of different ages. One-day-old female broilers (48 per treatment) were fed 4 different wheat-soybean-corn-based diets containing corn oil with a high PUFA n-6:n-3 ratio (HR) or a mixture of linseed and fish oils with a low PUFA n-6:n-3 ratio (LR). Diets contained either 50 mg vE kg−1 of diet (basal vE) or 300 mg vE kg−1 of diet (increased vE). At d 14 and d 34, 8 chickens per treatment were challenged with PHA, and wing web swelling (WWS) was measured. The blood concentration of leukotriene (LTB4), prostaglandin (PGE2), and thromboxane (TBX2) in 17-day-old and 43-day-old chickens was determined. The pattern of AA and DHA incorporation into bursa, spleen, and brain lipids reflected the level of their precursors in the diet. WWS was the highest in chickens fed a LR diet and in 14-day-old chickens (P < 0.01). Leukocyte proportions varied with dietary PUFA n-6:n-3 ratio and with age. The heterophil:lymphocyte ratio was the highest at 6 h post PHA challenge, and was higher in 34-day-old chickens (P < 0.001). TBX2 and PGE2 concentrations were higher in chickens fed HR diet, whereas TBX2 and LTB4 concentrations were lower at high vE level. Lower PGE2 and LTB4, but higher TBX2 concentrations were measured in younger birds (P < 0.001). The results indicated that LR increased the phagocytic cell proportion in the blood; HR promoted the incorporation of AA into the immune tissues, which increased the levels of more pro-inflammatory eicosanoids in the blood; and vE counteracts these effects to some extent. Owing to the immaturity of the immune system, dietary interventions might be promising at the early stage of chicken growth.

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The relationship between dietary fat sources and immune response in poultry and pigs: An updated review

Cited by 31 publications

References 81 publications

Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines

Prospects on the Use of Schizochytrium sp. to Develop Oral Vaccines

Effect of dietary fat level and source on performance and immune system response of turkeys

Interactive effects of dietary lipids and vitamin E level on performance, blood eicosanoids, and response to mitogen stimulation in broiler chickens of different ages

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