Effects of Estradiol, Testosterone, Diethylstilbestrol and Several of Their Derivatives upon the Human Oral Mucous Membrane

Richman, Mara J.; Abarbanel, A. R.

doi:10.14219/jada.archive.1943.0182

Cited by 31 publications

(11 citation statements)

References 6 publications

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“…Oral discomfort is also commonly reported by post-menopausal females, with 20-90% of women reporting a burning sensation, xerostomia, or bad taste (15,43), while only 6% of pre-menopausal women report the same (203). As with desquamative lesions, estrogens have been successfully used to gain pain relief under these circumstances (15,155,203), although direct correlation with these symptoms has yet to be established. In addition to gingival changes, reduced estrogen levels certainly may impact overall collagen metabolism, including bone maintenance, and result in a tendency toward development of osteoporosis.…”

Section: Menopausementioning

confidence: 99%

Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium

Mealey¹,

Moritz²

2003

Periodontology 2000

169

151

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Section: Menopausementioning

confidence: 99%

Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium

Mealey¹,

Moritz²

2003

Periodontology 2000

169

151

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“…Portions bordering the teeth FIGS. 16 19.-FIc. 16 have numerous fibrous lacunae, and the periphery or whole of many of the remaining marrow spaces has become filled with collagenous connective tissue.…”

Section: As Indicated Inmentioning

confidence: 99%

“…16 19.-FIc. 16 have numerous fibrous lacunae, and the periphery or whole of many of the remaining marrow spaces has become filled with collagenous connective tissue. The fibrosis is most marked near the crowns of the teeth, while some intact marrow can be found around the apexes of the roots.…”

Section: As Indicated Inmentioning

confidence: 99%

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Comparative Histology of Age Changes in Oral Tissues of Rat, Hamster, and Monkey

Klingsberg

Butcher

1960

J Dent Res

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In recent years there has been an increased awareness of the importance of those tissue changes which result from age. The numerous changes in the oral cavity of the rat include downgrowth of the epithelial attachment, increased inflammation, distal drift of the molars, loss of interproximal bone, continuous cemental deposition, and decreased width of the periodontal membrane.'-5 In a recent study on aging in mice,6 pocket formation, associated with accumulation of debris, was found to occur around the maxillary molars, but no downgrowth of the epithelial attachment was observed in the mandible. In the same study it was found that the non-trabecular bone of the 10-month-old animal became trabeculated and the marrow spaces filled with connective tissue by 24 months of age. Atrophy of the alveolar crest was not observed, although food impaction and inflammation increased with age. Studies on hamsters have disclosed an increased incidence of periodontal disease with increasing age.7-9 The disease process is characterized by accumulations of crevicular debris, inflammation, pocket formation, and downgrowth of the epithelial attachment. Using the smear technique in the study of the oral tissues of human patients, both increased keratinization10-12 and lack of change in the exfoliative cytology have been reported.'3 In another investigation on biopsied human gingiva, increased coarseness of the connective tissue fibers and decreased cellularity have been described.'4 No cytologic change was found in the epithelium or in the degree of cornification.'5 Atrophy of the prickle-cell layer of the oral mucous membrane, which can be modified by estradiol therapy, has been observed in postmenopausal patients.' In some aged individuals an atrophy of the oral mucous membrane, characterized by a loss of keratinization, loss of elasticity, and increased friability, has been described.'7' 18 In addition, a narrowing of the human periodontal membrane1 and a decrease in its cellular elements20 have been reported in the literature.In the present study, an attempt has been made to compare the aging patterns of two commonly used laboratory animals-the rat and the hamster-with those of a primate -the monkey. The studies on the rodents enabled us to observe the changes in lifespan in a short interval and compare them with those in a monkey. Presumably, the monkey may more closely simulate those changes which may be expected in the human.

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“…PhoshaMtaIs prearae3>Utrtion. 't nlllCo(Sn fromll n1or1'on 1 emitlolS lm <t. mc of'P mo ctol me kmmnttin1 -emmmmmtoxyl in a~nti cosin.…”

mentioning

confidence: 99%

Changes in Alkaline Phosphatase Activity of Rat Oral Epithelium During the Estrous Cycle and in Response to Administered Estrogen

Ring

Levy

1950

J Dent Res

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Effects of Estradiol, Testosterone, Diethylstilbestrol and Several of Their Derivatives upon the Human Oral Mucous Membrane

Cited by 31 publications

References 6 publications

Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium

Hormonal influences: effects of diabetes mellitus and endogenous female sex steroid hormones on the periodontium

Comparative Histology of Age Changes in Oral Tissues of Rat, Hamster, and Monkey

Changes in Alkaline Phosphatase Activity of Rat Oral Epithelium During the Estrous Cycle and in Response to Administered Estrogen

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