2001
DOI: 10.1097/00004872-200110000-00013
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Effects of ETA- and ETB-receptor antagonists on regional kidney blood flow, and responses to intravenous endothelin-1, in anaesthetized rabbits

Abstract: Endogenous ETs act at ET(A)-receptors to reduce MBF and CBF, but ET(B)-receptors have little direct role in physiological control of renal haemodynamics. Bolus doses of ET-1 act at ET(B)-receptors in the kidney to increase MBF. The effects of bolus ET-1 on the cortical vasculature appear to result from the competing influences of ET(A)-mediated vasoconstriction and ET(B)-mediated vasodilatation.

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Cited by 49 publications
(48 citation statements)
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“…This time course has been reported previously (1,5,19,31). The reason for the difference in the recovery rate is not clear.…”
Section: Discussionsupporting
confidence: 71%
“…This time course has been reported previously (1,5,19,31). The reason for the difference in the recovery rate is not clear.…”
Section: Discussionsupporting
confidence: 71%
“…Nevertheless, this seems to be a less serious problem for MBF (than for CBF), because the slope of the MLDF-RBF relationship in the isolated kidney was only slightly Ͻ1. We can also be confident that we can detect increases in MBF with the techniques used here, because we previously detected increases in CLDF and MLDF in response to vasodilators such as acetylcholine and bradykinin (30,33) and increases in MLDF in response to angiotensin II and endothelin-1 in a standard anesthetized rabbit preparation and in the extracorporeal circuit preparation (10)(11)(12). For example, in our standard rabbit preparation, a bolus of bradykinin into the renal artery has been shown to increase MLDF by ϳ100% from a baseline of ϳ100 units.…”
Section: Strengths and Limitations Of Laser-doppler Flowmetry For Estmentioning
confidence: 67%
“…For instance, Schneider and colleagues (42) provide strong evidence that nitric oxide signaling plays a role in ET-1 regulation of distal nephron Na ϩ handling. Similarly, modification of medullary blood flow and increased production of locally derived signaling factors, including P450 metabolites, in response to ET-1 have been implicated in ET-1-dependent regulation of collecting duct Na ϩ transport (5,12,13). The relative physiological importance and the relationship between these possible mechanisms of ET-1 control of ENaC remain unclear.…”
Section: Discussionmentioning
confidence: 99%