Effects of ethanol consumption on chromatin condensation and DNA integrity of epididymal spermatozoa in rat

Talebi, Ali Reza; Sarcheshmeh, Abolghasem Abbasi; Khalili, Mohammad Ali; Tabibnejad, Nasim

doi:10.1016/j.alcohol.2010.10.005

Cited by 84 publications

(57 citation statements)

References 52 publications

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“…This duration won't be able to complete a spermatogenesis cycle. However, the dose of ethanol liquid diet in supplemented in this study is higher (10 mg/kg compare to 5% v/v) compared to the study done by Talebi, Sarcheshmeh, Khalili, and Tabibnejad (2011). Despite of this situation, the findings suggested that ethanol consumption with or without hyperglycemic state decreased all sperm parameters and affected sperm DNA integrity.…”

Section: Preclinical Evidencecontrasting

confidence: 52%

See 1 more Smart Citation

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Jaafar¹,

Osman²,

Kumar³

et al. 2017

JAS

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There is no solid conclusion on the conventional sperm parameters in association with alcohol consumption, evaluation of sperm DNA integrity thus become a more reliable parameter. Hereby, this literature search was performed to summarize alcohol consumption on the sperm DNA integrity. A computerized database search was done through MEDLINE via Ovid (since 1946 until August 2017) and Cochrane was used. The following set of keywords: 'alcohol consumption OR alcohol intake OR alcohol diet OR drinking alcohol OR ethanol diet' AND 'sperm DNA OR sperm chromatin OR sperm genome OR sperm histone OR sperm protamine' were utilised. 24 articles were retrieved where only five studies conform to the inclusion criteria All studies demonstrated a negative effect of alcohol consumption on sperm DNA integrity, regardless of various range of alcohol doses and duration of alcohol consumption. Out of five studies reviewed, four studies were using a different approach to measure the sperm DNA damage. Hereby, this review identified a need to use a single approach of DNA damage test by having various method of alcohol administration and/or vice versa so that the extension of sperm DNA damage to alcohol consumption will have a better conclusion. On the same note, a few studies have reported the reversibility on conventional semen parameters, none has been done on the sperm DNA damage upon alcohol withdrawal. Therefore, the role of alcohol withdrawal on the reversibility of sperm DNA damage needs to be as well investigated further.

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Section: Preclinical Evidencecontrasting

confidence: 52%

“…Even though they did not have a positive and negative control on the sperm DNA evaluation, this study did test the efficacy and quality of the stain by using acid denaturation method in a normal sample. This study found out that ethanol caused DNA damage and affected its chromatin integrity (Talebi et al, 2011).…”

Section: Preclinical Evidencementioning

confidence: 99%

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Jaafar¹,

Osman²,

Kumar³

et al. 2017

JAS

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“…Alcohol exposure causes alterations of the endocrine system controlling the hypothalamic-pituitary-testicular axis function and a direct toxic effect on testis and/or male accessory glands [20–22]. Alcohol exposure is also reported to influence sperm DNA integrity [23, 24]. …”

Section: Introductionmentioning

confidence: 99%

Clinical Factors Associated with Sperm DNA Fragmentation in Male Patients with Infertility

Komiya

Kato

Kawauchi

et al. 2014

The Scientific World Journal

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Objective. The clinical factors associated with sperm DNA fragmentation (SDF) were investigated in male patients with infertility. Materials and Methods. Fifty-four ejaculates from infertile Japanese males were used. Thirty-three and twenty-one were from the patients with varicoceles and idiopathic causes of infertility, respectively. We performed blood tests, including the serum sex hormone levels, and conventional and computer-assisted semen analyses. The sperm nuclear vacuolization (SNV) was evaluated using a high-magnification microscope. The SDF was evaluated using the sperm chromatin dispersion test (SCDt) to determine the SDF index (SDFI). The SDFI was compared with semen parameters and other clinical variables, including lifestyle factors. Results. The SDFI was 41.3 ± 22.2% (mean ± standard deviation) and did not depend on the cause of infertility. Chronic alcohol use increased the SDFI to 49.6 ± 23.3% compared with 33.9 ± 18.0% in nondrinkers. The SDFI was related to adverse conventional semen parameters and sperm motion characteristics and correlated with the serum FSH level. The SNV showed a tendency to increase with the SDFI. The multivariate analysis revealed that the sperm progressive motility and chronic alcohol use were significant predictors of the SDF. Conclusion. The SCDt should be offered to chronic alcohol users and those with decreased sperm progressive motility.

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“…The results of this study confirmed that alcohol significantly reduced sperm concentration and motility compared with control rats and that pre-treatment with ASA was not able to revert these effects. 8 Talebi and colleagues 9 evaluated the effect of ethanol consumption on sperm parameters and chromatin integrity of spermatozoa aspirated from the epididymal cauda of rats allowed to drink ad libitum ethanol compared to control rats. The results showed that progressive and non-progressive motility were significantly lower in ethanol-consuming rats compared with control animals, whereas the percentage of anilineblue-reacted spermatozoa were similar in both groups.…”

Section: Introductionmentioning

confidence: 99%

Does alcohol have any effect on male reproductive function? A review of literature

Vignera¹,

Condorelli²,

Balercia³

et al. 2012

Asian J Androl

148

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Although alcohol is widely used, its impact on the male reproductive function is still controversial. Over the years, many studies have investigated the effects of alcohol consumption on sperm parameters and male infertility. This article reviews the main preclinical and clinical evidences. Studies conducted on the experimental animal have shown that a diet enriched with ethanol causes sperm parameter abnormalities, a number of alterations involving the reproductive tract inhibition, and reduced mouse oocyte in vitro fertilization rate. These effects were partly reversible upon discontinuation of alcohol consumption. Most of the studies evaluating the effects of alcohol in men have shown a negative impact on the sperm parameters. This has been reported to be associated with hypotestosteronemia and low-normal or elevated gonadotropin levels suggesting a combined central and testicular detrimental effect of alcohol. Nevertheless, alcohol consumption does not seem to have much effect on fertility either in in vitro fertilization programs or population-based studies. Finally, the genetic background and other concomitant, alcohol consumption-related conditions influence the degree of the testicular damage. In conclusion, alcohol consumption is associated with a deterioration of sperm parameters which may be partially reversible upon alcohol consumption discontinuation.

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Effects of ethanol consumption on chromatin condensation and DNA integrity of epididymal spermatozoa in rat

Cited by 84 publications

References 52 publications

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Effect of Alcohol Consumption on the Sperm DNA Integrity: A Systematic Review

Clinical Factors Associated with Sperm DNA Fragmentation in Male Patients with Infertility

Does alcohol have any effect on male reproductive function? A review of literature

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