Effects of Ethanol Extract from Sunkist (Citrus sinensis L. Osbeck) Peels on Rat’s Estrus Cycle

Mutia, Maya Sari; Suhartina,

doi:10.15395/mkb.v53n1.2167

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…The rotary evaporator underwent evaporation at a temperature of 40-50 o C, followed by water bath evaporation until it formed a concentrated extract. After that, the extract yield was determined by dividing the mass of the extract by the mass of the simplicial powder and multiple by 100% (Mutia, 2019;Suhartomi et al, 2020;Chiuman et al, 2021).…”

Section: Extraction Processmentioning

confidence: 99%

“…The dragon fruit peel extract was formulated into an oral suspension made of Na-CMC. 400 mg dragon fruit peels methanol extract and 20 mg loperamide were mixed into 10 ml 0.5% Na-CMC to form dragon fruit peels methanol extract and standard, respectively (Kanon, Fatimawati and Bodhi, 2012;Chiuman, 2019;Mutia and Chiuman, 2019).…”

Section: Oral Suspension Formulationmentioning

confidence: 99%

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In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract

Yosefa,

Tandanu,

Leslie

et al. 2023

Trad.Med.J

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Diarrhea is a global major health problem reported by 2.5 billion cases annually. Diarrhea accounts for 9% of child death worldwide or the second leading cause of death among toddlers. Many local people have used traditional medicine for diarrhea therapy. Dragon fruit is a herbal plant with high vitamins and various nutritious compounds. Therefore, this study determined antidiarrheal activity from dragon fruit peel methanolic extract (Hylocereus polyrhizus). This study was experimental with in vitro and in vivo models. The in vitro model used disc diffusion and microdilution assay against the diarrhea-causing pathogen (Escherichia coli). Meanwhile, the in vivo model used male Wistar rats induced by Castro oil. This study showed that the minimum inhibitory concentration (MIC) and minimum killing concentration (MKC) of dragon fruit peel extract against Escherichia coli were 50 and 100 mg/ml, respectively. The increased dose of dragon fruit peel methanol extract has increased the antidiarrheal index. The highest and lowest antidiarrheal index was found in the dragon fruit methanol extract-3 (76.56%) and dragon fruit methanol extract-1 (43.28%). The dragon fruit peel methanol extract can be proposed as antidiarrhea and antibacterial therapy against the diarrhea-causing pathogen.

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Section: Extraction Processmentioning

confidence: 99%

Section: Oral Suspension Formulationmentioning

confidence: 99%

In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract

Yosefa,

Tandanu,

Leslie

et al. 2023

Trad.Med.J

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“…In the last three days, all rats received a milliliter of copper sulfate suspension orally. (Yanti et al, 2011;Mutia, 2019;Mutia and Chiuman, 2019;Mutia, Ginting and Yulizal, 2021) Furthermore, all rats were sacrificed on the 15 th day by chloroform inhalation. After that, the blood was obtained by intracardiac puncture, and the liver was resected from incised abdomen wall.…”

Section: Hepatoprotective Assaymentioning

confidence: 99%

Liver Protection Effect of Red Rose Petal Methanol Extract in Copper-Induced Liver Injury in Male Wistar Rats

Hutagalung,

Girsang,

Mutia

et al. 2023

BIOMEDNATPROCH

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The human body requires low amounts of copper to maintain homeostasis, but high copper intake can cause various health problems. Many previous studies have been performed to look for natural products that can neutralize the excessive copper effect; one such natural product is a rose petal. Therefore, this study aims to investigate the liver protection effect of rose petals in copper-induced liver injury in male Wistar rats. This experimental study used thirty male Wistar rats that were grouped into five groups, including control, standard (quercetin), Rose Petal Methanol Extract-1 (400 mg/kg BW), 2 (800 mg/kg BW), and 3 (1,200 mg/kg BW). All groups were treated for 14 days, and all rats were given copper (II) sulfate suspension for the last three days. On the fifteenth day, all rats were sacrificed to obtain blood and liver tissue SGOT, SGPT, and liver histology study. The results showed that rose petal methanol extract significantly decreased SGOT and SGPT levels compared to the control group (P-value <0.05). The reduced area of ballooning degeneration and necrosis were in line with the increased dose of rose petal extract supported the liver protection effect of rose petal extract. Therefore, it can be concluded that rose petal methanol extract protects the liver against copper impacts.

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“…Suhartomi et al (2019) have been reported that both orange peel extract and fraction enriched by flavonoid, that was responsible for its antioxidant activity (Suhartomi et al, 2019). Mutia et al (2019) has been reported the hepatoprotective effect from the Sunkist peels extract from the Paracetamol-induce liver injury (Mutia & Chiuman, 2019). Furthermore, Mutia et al (2021) also reported that Sunkist peel ethanol extract has an antidiabetic effect that was also kidney protection effect from the diabetic nephropathy as the long-term complications (Sari et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Formulation and Physical Characteristics of Effervescent Granules from Sunkist Peels Ethanol Extract

Mutia,

Raibalaki,

Rahma

et al. 2023

jika

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Citrus fruit has a sweet taste and attractive shape, which is also enriched various health benefits. Some studies have been performed to investigate the pharmacology effects from the Sunkist peel extract. However, none of this study was look for the development of pharmaceutical products. Hence this study was performed to investigate the pharmaceutical formulation as an effervescent granule from Sunkist peel extract. This study was an experimental study to investigate the optimum formulation that was made by wet granulation methods. There were three formulation of Sunkist peel extract effervescent granule that were combination of organic acids (citric acid and tartaric acid), sodium bicarbonate as base compound, and some sweetener including aspartame, lactose, and mannitol. After that, the formulation was evaluated the physical properties including organoleptic, flow rate, dissolution time, foam height, pH, and angle of repose. The result of this study showed that these three formulations of Sunkist Peel extract effervescent granule showed significant different in almost all of physical properties including: flow rate (P-Value = 0.027), dissolution time (P-Value< 0.05), foam height (P-Value = 0.004), and angle of repose (P-Value: 0.043), except the degree of acidity or pH (P-Value = 0.128). Third formulation (F3) reveals the best physical properties as a Sunkist peel extract effervescent granule. Overall, it can be concluded that the third and second formulation fulfils a well physical properties of effervescent granule for Sunkist peel extract.

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Effects of Ethanol Extract from Sunkist (Citrus sinensis L. Osbeck) Peels on Rat’s Estrus Cycle

Cited by 3 publications

References 13 publications

In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract

In Vitro and In Vivo Antidiarrheal Activity of Dragon Fruit Peels Methanolic Extract

Liver Protection Effect of Red Rose Petal Methanol Extract in Copper-Induced Liver Injury in Male Wistar Rats

Formulation and Physical Characteristics of Effervescent Granules from Sunkist Peels Ethanol Extract

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