Effects of Exercise and Diet in Nonobese Asthma Patients—A Randomized Controlled Trial

Toennesen, Louise Lindhardt; Meteran, Howraman; Hostrup, Morten; Geiker, Nina Rica Wium; Jensen, Camilla; Porsbjerg, Celeste; Astrup, Arne; Bangsbo, Jens; Parker, Debbie; Backer, Vibeke

doi:10.1016/j.jaip.2017.09.028

Cited by 74 publications

(101 citation statements)

References 34 publications

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“…In various patient groups, 10‐20‐30 training conducted as cycling lowered blood pressure and fat mass and increased fat‐free mass and V˙O 2 max, with a high compliance . Furthermore, 10‐20‐30 training decreased blood pressure and lipid profile and increased V˙O 2 max and performance in trained individuals .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of 10‐20‐30 training versus moderate‐intensity continuous training on HbA1c, body composition and maximum oxygen uptake in male patients with type 2 diabetes: A randomized controlled trial

Baasch-Skytte

Lemgart

Oehlenschläger

et al. 2020

Diabetes Obesity Metabolism

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Aim: To compare the efficacy of 10-20-30 training versus moderate-intensity continuous training (MICT) on HbA1c, body composition and maximum oxygen uptake (V O 2 max) in male patients with type 2 diabetes (T2D). Materials and Methods: Fifty-one male participants with T2D were randomly assigned (1:1) to a 10-20-30 (N = 26) and a MICT (N = 25) training group. Interventions consisted of supervised cycling three times weekly for 10 weeks, lasting 29 minutes (10-20-30) and 50 minutes (MICT) in a local non-clinical setting. The primary outcome was change in HbA1c from baseline to 10-week follow-up. Results: Of 51 participants enrolled, 44 (mean age 61.0 ± 6.8 [mean ± SD] years, diagnosed 7.5 ± 5.8 years, baseline HbA1c 7.4% ± 1.3%) were included in the analysis. Training compliance was 84% and 86% in 10-20-30 and MICT, respectively. No adverse events occurred during the intervention. HbA1c decreased (P <0.001) by 0.5 (95% CI −0.72 to −0.21) percentage points with training in 10-20-30, with no change in MICT. The change in 10-20-30 was greater (P <0.05) than in MICT. Visceral fat mass decreased (P <0.05) only with 10-20-30 training, whereas total fat mass decreased (P <0.01) and V O 2 max increased (P <0.01) with training in both groups. Conclusions: Ten weeks of 10-20-30 training was superior to MICT in lowering HbA1c, and only 10-20-30 training decreased visceral fat mass in patients with T2D. Furthermore, 10-20-30 training was as effective as MICT in reducing total fat mass and increasing V O 2 max, despite a 42% lower training time commitment. K E Y W O R D S glycaemic control, high-intensity interval training, oral glucose tolerance test, skeletal muscle protein adaptations, sprint-interval training.

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Section: Introductionmentioning

confidence: 99%

Efficacy of 10‐20‐30 training versus moderate‐intensity continuous training on HbA1c, body composition and maximum oxygen uptake in male patients with type 2 diabetes: A randomized controlled trial

Baasch-Skytte

Lemgart

Oehlenschläger

et al. 2020

Diabetes Obesity Metabolism

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View full text Add to dashboard Cite

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“…To date, 10 randomised controlled trials (RCTs) have collectively reported benefits of supervised aerobic exercise training on a range of outcomes in adult patients with asthma such as exercise capacity, airway inflammation, disease exacerbation, clinical control, health-care use, psychosocial symptoms and asthma-related quality of life [30,[77][78][79][80][81][82][83][84][85][86]. In the largest and most recent RTC including 89 subjects with mild or moderate asthma, aerobic exercise at least three times a week for ≥ 30 minutes plus muscle training, and stretching, improved asthma control measured by the Asthma Control Test questionnaire and reduced shortness of breath [78].…”

Section: The Effect Of Exercise Training In Asthmamentioning

confidence: 99%

“…The above line of evidence sets the scientific rationale for combined interventions targeting physical activity, diet, and weight management in the important subset of asthmatic patients with obesity. Accordingly, a RCT showed that a two-month high-intensity interval training (spinning), when combined with high protein/low glycemic index diet improved asthma control and asthma-related quality of life in nonobese adults with asthma [85], although these effects were proven non-sustainable at one-year follow-up [125]. Importantly, in a RCT by Freitas and colleagues, exercise training combined with a weight loss program improved PADL in 55 grade II obese adults with asthma compared to weight loss alone, suggesting that if combined, these intervention can encourage obese asthmatic patients to become physically active [59].…”

Section: Combined Exercise Training and Diet/weight Loss Interventionsmentioning

confidence: 99%

Physical Activity: A Missing Link in Asthma Care

Panagiotou

Koulouris

Rovina

2020

JCM

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Asthma is the commonest respiratory disease and one of unceasingly increasing prevalence and burden. As such, asthma has attracted a major share or scientific interest and clinical attention. With the various clinical and pathophysiological aspects of asthma having been extensively investigated, the important association between asthma and physical activity remains underappreciated and insufficiently explored. Asthma impacts adversely on physical activity. Likewise, poor physical activity may lead to worse asthma outcomes. This concise clinical review presents the current recommendations for physical activity, discusses the available evidence on physical activity in asthma, and examines the causes of low physical activity in adult asthmatic patients. It also reviews the effect of daily physical activity and exercise training on the pathology and clinical outcomes of asthma. Finally, it summarizes the evidence on interventions targeting physical activity in asthma.

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“…However, the exercised group showed a significantly larger reduction in BMI, and therefore it is impossible to exclude confounding from reduced obesity-driven systemic inflammation. High-intensity intermittent exercise training without strength training has been looked at in adult asthmatic patients [49], and was shown to be beneficial in terms of symptom scores as assessed by Asthma Control Questionnaire (ACQ) and AQLQ. There were no significant changes in anti-inflammatory parameters, and the improvements in fitness and asthma control were not sustained at 1 year [53].…”

Section: Effect Of Exercise On Inflammation In Adultsmentioning

confidence: 99%

Defining a role for exercise training in the management of asthma

2020

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The prevalence of asthma remains high worldwide, with increasing awareness of the morbidity and mortality from asthma in low-income countries. In the UK, despite the development of biological treatments, many patients remain suboptimally controlled, and mortality rates have been static for decades. Therefore, new approaches are needed to treat asthma that are scalable at minimal cost. Exercise immunology is an expanding field, and there is growing evidence that exercise can modulate inflammatory and immune processes in asthma. Whilst exercise is encouraged in current treatment guidelines, there are no specific recommendations as to the intensity, frequency or duration of exercise exposure. Despite national and international guidance to increase exercise, patients with asthma are less likely to engage in physical activity. This review explores the disease modifying benefit of exercise in asthma. We also review the domains in which exercise exerts positive clinical effects in asthma, including the effects of exercise on symptom scores, quality of life, psychosocial health, and in the obese asthma phenotype. Finally, we review the barriers to exercise in asthma, given the benefits it confers. A better understanding of the mechanisms through which exercise exerts its positive effects in asthma may provide more accurate prescription of exercise training programmes as part of broader asthma management, with the potential of identification of new drug targets.

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Effects of Exercise and Diet in Nonobese Asthma Patients—A Randomized Controlled Trial

Cited by 74 publications

References 34 publications

Efficacy of 10‐20‐30 training versus moderate‐intensity continuous training on HbA1c, body composition and maximum oxygen uptake in male patients with type 2 diabetes: A randomized controlled trial

Efficacy of 10‐20‐30 training versus moderate‐intensity continuous training on HbA1c, body composition and maximum oxygen uptake in male patients with type 2 diabetes: A randomized controlled trial

Physical Activity: A Missing Link in Asthma Care

Defining a role for exercise training in the management of asthma

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