Effects of Fermented Barley Extract on Antioxidant Status in Mice

Abstract

Effects of dietary supplementation with Fermented barley extract (FBE) on lipid metabolism and antioxidant status in mice were studied. In experiment 1, male 5-month-old mice were fed either a control diet or an experimental diet containing 10% barley, fermented barley fiber (striated part of barley grain) or FBE for 3 months. In experiment 2, male 5-month-old mice were fed either a control diet or an experimental diet containing FBE or FBEP (adsorbed fraction of FBE on the hydrophobic resin) for 3 months. The thiobarbituric acid-reactive substances (TBARS) concentrations in both plasma and liver were significantly lower in the FBE and FBEP groups than the control group. Erythrocyte glutathione peroxidase activity was significantly higher in the FBEP group than in the other groups. Liver glutathione content was significantly higher in the FBEP group than in the control group. These results suggest that FBEP, prepared from the water-soluble fraction of barley-shochu distillery by-products, significantly reduces oxidative stress in the body.

Fermented barley extract supplementation ameliorates metabolic state in stroke-prone spontaneously hypertensive rats

“…Our previous study showed that indices of oxidative stress were significantly reduced in mice fed 5% FBEP diet for three months. 36) In another experiment, administration of FBEP (2 or 4 g/kg body weight) enhanced urinary excretion of uric acid in adenine-induced urinary hyperuricemia model in dose dependent manner. 12) Therefore, we suggest that optimal dose of FBEP may be varied among the experimental disease models.…”

Effects of Single and Combined Administration of Fermented Barley Extract and γ-Aminobutyric Acid on the Development of Atopic Dermatitis in NC/Nga Mice

“…We confirmed an increase in erythrocyte glutathione peroxidase activity as well as an increased effect on the hepatic GSH level in the mixed feeding test of FBEP using normal mice. 8) On the other hand, it has been reported that antigen-presenting cells (APCs) contain abundant levels of reduced-type GSH and produce large amounts of IL-12, which can induce differentiation of naive T cells into the Th1 type. 25,26) The existence of a Splenocytes were prepared from NC/Nga mice 10 weeks after the initial challenge with PiCl.…”

“…6,7) Additionally, oral administration of FBEP (the adsorbed fraction of FBE on the hydrophobic resin) in mice resulted in reduced oxidative stress by controlling glutathione-redox. 8) On the other hand, Iguchi et al 9,10) reported that administration of FBE to mice with ovalbumin-sensitized rhinitis reduced the increase in frequency of sneezing and nose-scratching. Furthermore, the development of AD-like skin lesions in NC/Nga mice was reduced by alterations in the cytokines involved in chronic inflammation, such as interferon (IFN)-and IL-17.…”

Anti-hyperuricemic Effect of Fermented Barley Extract is Associated with Increased Urinary Uric Acid Excretion

“…In FBE obtained from shochu distillery by-products (SDB), physiological effects, such as the inhibitory action on hepatic disorder (Mochizuki et al, 2001;Mochizuki et al, 2005), anti-oxidative stress (Hokazono et al, 2009), and anti-inflammatory action (Giriwono et al, 2010), have been confirmed at the level of animal studies. Furthermore, serum UA levels were significantly reduced after continuous intake of FBEP (obtained from FBE) for 12 weeks in a double blind, parallel group comparison test using Japanese adults with slightly elevated UA levels .…”