Effects of fine particulate matter on the ocular surface: An in vitro and in vivo study

Yang, Qian; Li, Kunke; Li, Dai; Zhang, Yafang; Liu, Xiuping; Wu, Kaili

doi:10.1016/j.biopha.2019.109177

Cited by 59 publications

(51 citation statements)

References 46 publications

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“…Epithelial damage is mainly caused by cell death, including apoptosis. It has been reported that PM may directly cause corneal epithelial apoptosis [16]. In this study, we observed that PM decreased tear volume and LPE recovered the decreased tear volume due to PM.…”

Section: Discussionsupporting

confidence: 65%

“…DES is driven by low lacrimal flow and high evaporation that leads to reduced tear volume [32]. e exposure to PM also induces significant toxicity and damage to the ocular surface, including the cornea and conjunctiva [16]. Damaged corneal and conjunctival epithelia lead to barrier dysfunction, which is ascribed to dry eye syndrome [33].…”

Section: Discussionmentioning

confidence: 99%

“…DES can be caused by various factors such as aging, smoking, health condition, and medications, but it can also be caused by PM exposure. Continuous PM exposure reduces tear film stability, influences the tear osmolality [9], delays corneal epithelium wound healing by inhibiting cell migration [15], and increases oxidation stress on the ocular surface [16]. Furthermore, PAH mixtures increase eye irritation and photosensitivity [17], and high concentrations of heavy metals are associated with DES induction [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter

Song

Hyun

Lee

et al. 2019

Journal of Ophthalmology

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Particulate matter (PM) is a type of air pollutant that poses a risk to human health. In the ocular system, PM causes or aggravates dry eye syndrome (DES) by damaging the corneal and conjunctival epithelia. Liriope platyphylla has been used traditionally as an expectorant, antitussive agent, and tonic in Korea. However, the effects of Liriope platyphylla extract (LPE) on PM-induced ocular damage have not been elucidated. In this study, we evaluated the in vivo protective effect of LPE against PM-induced DES in rats. Topical administration of LPE attenuated the PM-induced decrease in tear volume and reduced corneal epithelial irregularity and damage. LPE also protected against PM-induced disruption of the corneal mucin-4 layer and reduction in the conjunctival goblet cell density. These findings suggest that LPE has protective effects against PM-induced DES.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter

Song

Hyun

Lee

et al. 2019

Journal of Ophthalmology

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“…The concentration of UPM for topical application to the eye was determined according to previous studies [10,11,18]. Injury of the ocular surface was assessed by scoring fluorescein staining levels on the cornea.…”

Section: Effects Of Upm On the Ocular Surface In Ratsmentioning

confidence: 99%

“…However, some studies have suggested that the compositions of components are more important than the concentrations of PM in terms of toxic effects [17]. A study using Standard Reference Material (SRM 2786) showed that the long-term effects of PM2.5 treatment for 6 months in mice also result in PM2.5-induced dry eye-like symptoms, but the results did not clarify the differences between long-term and short-term exposure [18].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats

Kang

Choi

Jang

et al. 2020

IJMS

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We investigated the time-dependent deleterious ocular changes induced by urban particulate matter (UPM) in vitro and in vivo. UPM treatment decreased human corneal epithelial cell migration and survival. Fluorescein scores were consistently increased by UPM application for 16 weeks. One week of rest at 2 or 4 weeks led to a recovery trend, whereas two weeks of rest at 8 weeks induced no change. UPM treatment decreased the tear film break-up time at 2 weeks, which was thereafter maintained until 16 weeks. No changes were found after periods of rest. UPM-treated eyes exhibited greater corneal epithelium thickness than normal eyes at 2 weeks, which recovered to normal at 4 and 8 weeks and was significantly decreased at 16 weeks. Apoptotic cell number in the epithelium was increased at 2 weeks, which remained constant except at 8 weeks. IL-6 expression in the cornea of the right eye continually increased for 16 weeks, and significant recovery was only observed at 8 weeks after 2 weeks of rest. Ocular pressure was significantly increased in the right eye at 12 and 16 weeks. Topical UPM application to the eye induced deleterious changes to various closely related parts of the eye.

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Fine particulate matter measured by satellites predicts the risk of age-related macular degeneration in a longitudinal cohort study

Liang

Wang

Jung

et al. 2022

Environ Sci Pollut Res

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Effects of fine particulate matter on the ocular surface: An in vitro and in vivo study

Cited by 59 publications

References 46 publications

Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter

Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter

Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats

Fine particulate matter measured by satellites predicts the risk of age-related macular degeneration in a longitudinal cohort study

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