Effects of fluoride on metabolism and mechanical properties of rat bone

Wolinsky, Ira; Simkin, Ariel; Guggenheim, K.

doi:10.1152/ajplegacy.1972.223.1.46

Cited by 57 publications

(13 citation statements)

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“…He concludes that the fluoride could not prevent bone disappearance in rats as an effect of the calcium difficiency in the food. Wolinsky et al (1972) found in a similar study of whole rat femur tested in bending a decrease in breaking strength and elastic stiffness at 500 ppm dose level compared to controls (5 ppm) but no change in energy absorption to the breaking point. In a study of the whole rabbit femur Faccini (1969) found an increase in strength as an effect of fluoride but concluded that this was due to an increase in the width of the cortex and not to a change of the quality of bone, breaking and elasticity being in fact significantly reduced.…”

Section: In Humansmentioning

confidence: 60%

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Physical Properties and Chemical Content of Canine Femoral Cortical Bone in Nutritional Osteopenia its Reversibility and the Effect of Fluoride

Romanus

1974

Acta Orthopaedica Scandinavica

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Section: In Humansmentioning

confidence: 60%

“…Wolinsky et al (1972) found on the other hand a decreasing bending strength and elastic stiffness at high dose level (500 ppm). Similar findings were earlier presented by Jovanovits (1944) with decreased breaking strength and elastic stiffness with increasing doses and time of fluoride addition.…”

Section: Summary Of Effects Of Fluoride Additionmentioning

confidence: 85%

Physical Properties and Chemical Content of Canine Femoral Cortical Bone in Nutritional Osteopenia its Reversibility and the Effect of Fluoride

Romanus

1974

Acta Orthopaedica Scandinavica

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“…A similar controversy is found in epidemiological reports on the effects of water fluoridation on the incidence of hip fractures (19)(20)(21). In animal studies, where biomechanical data are available, NaF was reported to increase (22), decrease (23)(24)(25), or have no effect on bone strength (26)(27)(28). Short-term studies in ewes showed that at a low dose NaF stimulates bone formation by increasing the recruitment and lifespan of osteoblasts; at higher doses, NaF decreased osteoblast activity (29).…”

Section: Introductionmentioning

confidence: 63%

“…The accretion of bone in response to fluoride therapy has been documented in the vertebrae by bone density measurements (8,10,48) and in cancellous bone by iliac crest biopsies (49). Several animal studies using mechanical testing have shown a deterioration in bone "quality" with increased bone fluoride content (23)(24)(25)(26)33). Another therapy, which raised questions regarding the correlation of bone mass and fracture incidence, is treatment with the bisphosphonate etidronate (EHDP).…”

Section: Discussionmentioning

confidence: 99%

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

Lafage

Balena²,

Battle³

et al. 1995

J. Clin. Invest.

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Fluoride stimulates trabecular bone formation, whereas bisphosphonates reduce bone resorption and turnover. Fracture prevention has not been convincingly demonstrated for either treatment so far. We compared the effects of 1-yr treatment of 9-mo-old minipigs with sodium fluoride (NaF, 2 mg/kg/d p.o.) or alendronate (ALN, 4 amino-l-hydroxy-on the biomechanical and histomorphometric properties of pig bones. As expected, NaF increased and ALN decreased bone turnover, but in these normal animals neither changed mean bone volume. NaF reduced the strength of cancerous bone from the LA vertebra, relative to control animals, and the stiffness (resistance to deformation) of the femora, relative to the ALN group. In the ALN-treated animals, there was a strong positive correlation between bone strength and L5 cancerous bone volume, but no such correlation was observed in the NaF group. Furthermore, the modulus (resistance to deformation of the tissue) was inversely related to NaF content and there was a relative decrease in bone strength above 0.25 mg NaF/g bone. Moreover, within the range of changes measured in this study, there was an inverse correlation between bone turnover, estimated as the percentage of osteoid surface, and modulus. These findings have relevant implications regarding the use of these agents for osteoporosis therapy. (J. Clin. Invest. 1995. 95:2127-2133

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“…The entire fresh, right femurs of the animals were used in breaking strength studies, the left femur employed for chemical measurements. The preparation of bone tissue, determina tions of dry weight, ash, calcium and phosphorus, and the instrumentation and calculations of mechanical parameters have been described previously (16). Ultimate stress is the maximum stress a material will sustain at failure; modulus of elasticity is the measure of the stiffness of the material, i .e.…”

Section: Methodsmentioning

confidence: 99%

Effect of Repletion with Dietary Calcium on Composition and Mechanical Properties of Bone of Calcium-Deprived Rats

Galfsky¹,

Wolinsky²,

Simkin³

et al. 1975

Ann Nutr Metab

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Four groups of rats were fed a low-calcium diet (0.02 %) and two groups a normal calcium diet (0.50 %). After 2 weeks one group from each dietary calcium level was sacrificed and the femurs examined. The remaining three groups which had been kept on the low-calcium diet were then given diets richer in calcium: 0.25, 0.35 and 0.5 %. The remaining group on the normal calcium diet continued receiving it. After two more weeks all animals were sacrificed and their femurs examined. Rats fed the low-calcium diet lagged behind in weight gain; ash content, breaking strength, and modulus of elasticity of their femurs were much lower than those of animals on the normal calcium diet. Feeding diets with increasing calcium content increased bone ash and improved mechanical properties. However, improvement of breaking strength and elasticity did not parallel strictly increases in mineralization. Repletion with a normal calcium diet (0.50 %) failed to increase bone ash to normal levels but mechanical properties were improved by repletion with substantially lower dietary calcium levels. Maximal breaking strength was obtained by repletion feeding with a dietary calcium level which failed to increase bone ash. It seems that factors other than mineralization determine breaking strength and elasticity of bone recovering from calcium deprivation.

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Effects of fluoride on metabolism and mechanical properties of rat bone

Cited by 57 publications

References 0 publications

Physical Properties and Chemical Content of Canine Femoral Cortical Bone in Nutritional Osteopenia its Reversibility and the Effect of Fluoride

Physical Properties and Chemical Content of Canine Femoral Cortical Bone in Nutritional Osteopenia its Reversibility and the Effect of Fluoride

Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.

Effect of Repletion with Dietary Calcium on Composition and Mechanical Properties of Bone of Calcium-Deprived Rats

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