Effects of fried potato chip supplementation on mouse pregnancy and fetal development

El‐Sayyad, Hassan I.; Abou-Egla, Mohamed H.; El-Sayyad, Fawkia I.; El-Ghawet, Heba A.; Gaur, Rajiv L.; Fernando, Augusta; Raj, Minakshi; Ouhtit, Allal

doi:10.1016/j.nut.2010.11.005

Cited by 42 publications

(23 citation statements)

References 33 publications

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“…Decreases in offspring body weight following maternal acrylamide exposure during gestation have been consistently observed in mice and rats (El Sayyad et al 2011; Tyl and Friedman 2003). A U.S. National Toxicology Program evaluation panel concluded that acrylamide causes decreased birth weight in rodents (Manson et al 2005), although the mechanisms underlying the effects of acrylamide on birth weight are not understood.…”

Section: Discussionmentioning

confidence: 99%

“…Worldwide concern about potential health effects of dietary exposure to acrylamide followed the finding of acrylamide in commonly consumed foods such as fried potatoes, potato chips, biscuits, breakfast cereals, and coffee [European Food Safety Authority (EFSA) 2010; Joint FAO/WHO (Food and Agriculture Organization/World Health Organization) Expert Committee on Food Additives (JECFA) 2011; Manson et al 2005]. Prenatal exposure to acrylamide is of particular concern because reproductive and developmental toxicity of acrylamide has been reported in rodents, including dose-dependent body weight reduction and skeletal malformations in offspring exposed in utero (El Sayyad et al 2011; Manson et al 2005; Tyl and Friedman 2003). …”

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confidence: 99%

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Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

Pedersen

Stedingk

Botsivali

et al. 2012

Environ Health Perspect

100

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Background: Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents.Objectives: We examined the associations between prenatal exposure to acrylamide and birth outcomes in a prospective European mother–child study.Methods: Hemoglobin (Hb) adducts of acrylamide and its metabolite glycidamide were measured in cord blood (reflecting cumulated exposure in the last months of pregnancy) from 1,101 singleton pregnant women recruited in Denmark, England, Greece, Norway, and Spain during 2006–2010. Maternal diet was estimated through food-frequency questionnaires.Results: Both acrylamide and glycidamide Hb adducts were associated with a statistically significant reduction in birth weight and head circumference. The estimated difference in birth weight for infants in the highest versus lowest quartile of acrylamide Hb adduct levels after adjusting for gestational age and country was –132 g (95% CI: –207, –56); the corresponding difference for head circumference was –0.33 cm (95% CI: –0.61, –0.06). Findings were similar in infants of nonsmokers, were consistent across countries, and remained after adjustment for factors associated with reduced birth weight. Maternal consumption of foods rich in acrylamide, such as fried potatoes, was associated with cord blood acrylamide adduct levels and with reduced birth weight.Conclusions: Dietary exposure to acrylamide was associated with reduced birth weight and head circumference. Consumption of specific foods during pregnancy was associated with higher acrylamide exposure in utero. If confirmed, these findings suggest that dietary intake of acrylamide should be reduced among pregnant women.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

Pedersen

Stedingk

Botsivali

et al. 2012

Environ Health Perspect

100

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“…Acrylamide is known to cross the placenta81 with nonsignificant amounts transferring to the infant through breast milk 82. Rodent models have demonstrated that prenatal and perinatal acrylamide exposures result in low birth weight offspring that develop signs of liver toxicity and lipid accumulation in postnatal life 83,84. Meanwhile, administration of acrylamide to adult rodents has been shown to increase glycogen content and increase hepatocyte size in addition to causing dysglycemia and elevated serum lipid levels 85.…”

Section: Food Processingmentioning

confidence: 99%

Early-life chemical exposures and risk of metabolic syndrome

Long

Holloway

2017

DMSO

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The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology and pathophysiology of metabolic diseases. Importantly, exposures occurring in early life (in utero and early childhood) may have a more profound effect on life-long risk of obesity and MetS. This narrative review explores the evidence linking early-life exposure to a suite of chemicals that are common contaminants associated with food production (pesticides; imidacloprid, chlorpyrifos, and glyphosate) and processing (acrylamide), in addition to chemicals ubiquitously found in our household goods (brominated flame retardants) and drinking water (heavy metals) and changes in key pathways important for the development of MetS and obesity.

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“…23, 24 The body weight-lowing effect of acrylamide was repeatedly demonstrated in many animal models in either acute, 25, 26 intermediate 25, 27, 28 or chronic exposure. 25 It has been shown that daily high dose acrylamide exposure can result in a decrease in appetite motivation or a reduced rate of weight gain, 29, 30 which might be mediated through increased oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Negative association between acrylamide exposure and body composition in adults: NHANES, 2003–2004

Lai

Chen

et al. 2017

Nutr & Diabetes

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Background/Objectives:Acrylamide is present in mainstream cigarette smoke and in some food prepared at high temperature. Animal studies have shown that acrylamide exposure reduces body weight. Prenatal exposure to acrylamide also has been linked to reduced birth weight in human. Whether acrylamide exposure is associated with altered body compositions in adults is not clear.Subjects/Methods:We selected 3623 subjects (aged ⩾20 years) from a National Health and Nutrition Examination Survey (NHANES) in 2003–2004 to determine the relationship among hemoglobin adducts of acrylamide (HbAA), hemoglobin adducts of glycidamide (HbGA) and body composition (body measures, bioelectrical impedance analysis (BIA), dual energy x-ray absorptiometry (DXA)). Data were adjusted for potential confounding variables.Results:The geometric means and 95% CI concentrations of HbAA and HbGA were 60.48 (59.32–61.65) pmol/g Hb and 55.64 (54.40–56.92) pmol/g Hb, respectively. After weighting for sampling strategy, we identified that one-unit increase in natural log-HbAA, but not HbGA, was associated with reduction in body measures (body weight, body mass index (BMI), subscapular/triceps skinfold), parameters of BIA (fat-free mass, fat mass, percent body fat, total body water) and parameters of DXA (android fat mass, android percent fat, gynoid fat/lean mass, gynoid percent mass, android to gynoid ratio). Subgroup analysis showed that these associations were more evident in subjects at younger age, male gender, whites, lower education level, active smokers and those with lower BMI.Conclusions:Higher concentrations of HbAA are associated with a decrease in body composition in the US general population. Further studies are warranted to clarify this association.

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Effects of fried potato chip supplementation on mouse pregnancy and fetal development

Cited by 42 publications

References 33 publications

Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

Early-life chemical exposures and risk of metabolic syndrome

Negative association between acrylamide exposure and body composition in adults: NHANES, 2003–2004

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