Effects of Gaseous Air Pollutants on Gastric Secreto-Motor Activities in the Rat

Roth, Roland P.; Tansy, Martin F.

doi:10.1080/00022470.1972.10469703

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…[36] However, low-level exposures were not associated with gastric dysmotility. [36] Another study demonstrated that animals fed EHC-6802 had increased IL-8 secretion from the small bowel and experienced changes in the composition of colonic microflora. [37] Our in vitro studies demonstrated impaired colonic, but not ileal, contractility after the acute exposure of the ex-vivo tissue with the particulate matter.…”

Section: Discussionmentioning

confidence: 97%

Non-Specific Abdominal Pain and Air Pollution: A Novel Association

et al. 2012

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BackgroundWe studied whether short-term exposure to air pollution was associated with non-specific abdominal pain in epidemiologic and animal studies.MethodsPatients visiting the emergency department with non-specific abdominal pain were identified in Edmonton (1992 to 2002, n = 95,173) and Montreal (1997 to 2002, n = 25,852). We calculated the daily concentrations for ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), and particles <10 (PM10) or <2.5 (PM2.5) µm. A case crossover study design was used to estimate the odds ratio (OR) and 95% confidence interval (CI) associated with an increase in the interquartile range of the air pollutants. We investigated differential effects by age and sex. Mice were gavaged with urban particle extracts. In animal models, colonic motility was tested, and visceral abdominal pain was measured using a writhing test, and behavioral response to oil of mustard and neostigmine. Motility and pain was measured acutely (1.5 hours after gavage) and chronically (7-days and 21-days after gavage).ResultsEmergency department visits for non-specific abdominal pain were primarily by women between the ages of 15–24 years. Individuals aged 15 to 24 years were at increased risk of non-specific abdominal pain in Edmonton (same day CO: OR = 1.04, 95% CI = 1.02–1.06; and NO2: OR = 1.06, 95% CI = 1.03–1.09). The risk of air pollution among 15–24 year olds in Montreal was significantly positive (same day CO: OR = 1.11, 95% CI = 1.05–1.17; NO2: OR = 1.09, 95% CI = 1.01–1.16; SO2: OR = 1.17, 95% CI = 1.10–1.25; PM2.5: OR = 1.09, 95% CI = 1.04–1.15). Abdominal pain was increased by an acute gavage of pollution extract but not to chronic exposure to pollutants. Colonic transit was delayed following chronic but not acute exposure with the pollutants.ConclusionsEpidemiological and animal data suggest that short-term exposure to air pollution may trigger non-specific abdominal pain in young individuals.

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Section: Discussionmentioning

confidence: 97%

Non-Specific Abdominal Pain and Air Pollution: A Novel Association

et al. 2012

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“…In one study high concentrations of air pollutants (NO 2 , CO, and O 3 ) impaired gastric basal contractility. [36] However, low-level exposures were not associated with gastric dysmotility. [36] Another study demonstrated that animals fed EHC-6802 had increased IL-8 secretion from the small bowel and experienced changes in the composition of colonic microflora.…”

Section: Discussionmentioning

confidence: 99%