Effects of genetic variants of ADH1B and ALDH2 and social network on continued alcohol drinking among young adolescents in Taiwan

Ting, Te Tien; Huang, Shiao Yun; Chen, Kuang Hung; Tseng, Ching Ing; Lin, Keh Ming; Chen, Chuan Yu; Chen, Wei-Jen

doi:10.1016/j.drugalcdep.2014.12.014

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…Out of the remaining participants, 24 had ALDH2 GG, 27 ALDH2 AG, and 7 ALDH2 AA genotypes. According to Ting et al, the ALDH2 A allele incidence rate in Taiwan was 0.29 [46], but the incidence rate in our study participants was 0.35; statistical analysis revealed that the incidence rate of ALDH2 A alleles found in our study groups was representative of the incidence rate in the population, according to Hardy-Weinberg equilibrium. Nonetheless, it might be a point of future studies to verify that the observed increase in incidence rate of ALDH2 A alleles in opiate users were merely by chance.…”

Section: Resultscontrasting

confidence: 46%

Effect of Aldehyde Dehydrogenase 2 Gene Polymorphism on Executive Function in Opiate User

Liu¹,

Chen²,

Lu³

et al. 2018

Neuropsychiatry

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Objective: The use of opiate substances, such as heroin and methadone, has been proven to cause executive function damage. The extent of damage may be mediated by the activity of enzyme aldehyde dehydrogenase 2 (ALDH2), which plays an important role in neurotransmitter dopamine metabolism. The single nucleotide polymorphism Glu487Lys distributes mostly in Asia and codes for ALDH2 with greatly reduced enzyme activity. The current study aims to explore the effect of ALDH2 on executive function in opiate users. Methods: A total of 94 opiate users were recruited and 58 patients finished the neuropsychological assessment and blood genotyping. Results: After co-variating the influence of age and the years of education, we found that participants with ALDH2 A allele performed worse on the Category Complete index of the Modified Wisconsin Card Sorting Test (F = 5.34, p = 0.02), suggesting an impaired planning ability in this group. We also found that ALDH2 A carriers went through the Trail 2 in Color Trails Test faster (F = 8.21, p = 0.01), in part suggesting better set-shifting abilities; however, impulsiveness and lack of planning associated with this study group may also explain the faster performances. Conclusions: The role that ALDH2 plays in the pathology of cognitive impairment in opiate users may lead new focus in studies of the pathophysiology in opiate usage and its consequences on cognitive function.

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Section: Resultscontrasting

confidence: 46%

Effect of Aldehyde Dehydrogenase 2 Gene Polymorphism on Executive Function in Opiate User

Liu¹,

Chen²,

Lu³

et al. 2018

Neuropsychiatry

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“…Nevertheless, studies suggest that the environmental factor has a bigger impact than the genetic factor in influencing alcohol drinking habits. 20,21 If the individuals were carrying polymorphic ALDH2 allele drink alcohol, the risk of acetaldehyde accumulation increasing. It may lead to various chronic diseases.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers

Busyra

Nurhantari

Suhartini

et al. 2021

J Community Empowerment for Health

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Chronic kidney disease is a preventable high-burden disease. Several risk factors for impaired kidney function have been identified, including lifestyles, such as alcohol drinking and cigarette smoking. However, the evidence remains inconsistent. East Nusa Tenggara has the largest proportion of heavy alcohol drinking among all provinces in Indonesia. Genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) is related to alcohol drinking behavior through the inactivity of the ALDH2 enzyme, which leads to toxic acetaldehyde accumulation. This study aims to recognize the linkage of ALDH2 genotypes to kidney function among alcohol drinkers and cigarette smokers in East Nusa Tenggara. This study was a cross-sectional study of East Nusa Tenggara ethnicity, aged 18-60 years old. Demographic and lifestyle data were obtained via a questionnaire. DNA analysis was conducted with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Creatinine and BUN levels were measured with a chemistry analyzer. Afterward, the estimated glomerular filtration rate (eGFR) was calculated from creatinine value using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. The association between kidney function status and alcohol drinking and cigarette smoking habits were analyzed using the chi-square test, then stratified based on genotype groups. Fifty-one subjects were included in this study, while the mean age was 26.33±1.33 years and the median age was 22 years. There were 37 (72.5%) alcohol drinkers and 14 (27.5%) non-drinkers; 28 (54,9%) cigarette smokers and 23 (45.1%) non-smokers. This study revealed no significant association between kidney function status and alcohol drinking habits. Cigarette smoking habits were inversely associated with eGFR decline and creatinine elevation in wild-type ALDH2 groups.

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“…These findings illustrate the interplay between ADH1B allelic variants and peer drinking on adolescent alcohol use patterns. Along the same lines, in a sample of 496 Chinese children, the polymorphism of ADH1B (rs1229984) and ALDH2 (rs671) was evaluated, whereby latent class analysis the longitudinal pattern of alcohol use was characterized, followed by multi-nominal logistic regression analysis to assess the association of these genetic variants with pubertal development and social networks 34 . The results showed that both genes appeared to have protective effects, but such an effect was only significant in young people at the onset of puberty.…”

Section: Alcoholmentioning

confidence: 99%

Etiopatogenia de las drogodependencias: una síntesis explicativa desde una perspectiva epigenética

Miranda

Palomino²,

Arismendy-López³

et al. 2022

medupb

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El consumo de sustancias con potencial adictivo es un problema relevante de salud. La evidencia científica sugiere que los mecanismos subyacentes que regulan los procesos comportamentales en las adicciones involucran un complejo interjuego entre factores genéticos y ambientales. Por lo tanto, esta revisión narrativa tiene como objetivo aportar un marco de referencia que permita sintetizar la evidencia sobre interacciones genes- ambiente-agente desde la perspectiva de la historia natural de la enfermedad y los estadios del proceso adictivo para: alcohol, nicotina, cannabis, psicoestimulantes y opioides. En esta revisión realizamos una búsqueda exhaustiva de la literatura sin límites de tiempo en PubMed, Ebsco, Lilacs y SciELO, revisando el título y el resumen se seleccionaron artículos originales en humanos o animales que abordaran la etiología de las adiciones según el enfoque metodológico de interacción entre genes y ambiente (G-A), incluyendo artículos en español, inglés y portugués. Los estudios genéticos han revelado el papel crítico de los modificadores epigenéticos (acetilación de las histonas) en mantener la homeóstasis cerebral en condiciones patológicas y enfocarse en las interacciones G-A también permitirá caracterizar subgrupos (basados en los factoresambientales) de alto riesgo para conductas adictivas que pueden ser objeto de intervenciones específicas, por lo que, las estrategias de tratamiento deben englobar una combinación de intervenciones psicosociales con terapia génica que involucren las manipulaciones farmacológicas de las histonas que pueden contribuir a diseñar mejores terapias y tal vez conducir a un manejo más exitoso de las drogodependencias.

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Effects of genetic variants of ADH1B and ALDH2 and social network on continued alcohol drinking among young adolescents in Taiwan

Cited by 5 publications

References 47 publications

Effect of Aldehyde Dehydrogenase 2 Gene Polymorphism on Executive Function in Opiate User

Effect of Aldehyde Dehydrogenase 2 Gene Polymorphism on Executive Function in Opiate User

Genetic polymorphism of ALDH2 linkage to kidney function status of East Nusa Tenggara alcohol drinkers and cigarette smokers

Etiopatogenia de las drogodependencias: una síntesis explicativa desde una perspectiva epigenética

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