Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice

Kim, Young Gon; Sumiyoshi, Maho; Sakanaka, Masahiro; Kimura, Yoshiyuki

doi:10.1016/j.ejphar.2008.11.021

Cited by 79 publications

(60 citation statements)

References 35 publications

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“…Previous research has reported that ginseng has several beneficial effects on human and animal skin [3][4][5][6][7]. Kim et al [36] reported that topical applications of total ginseng saponins (10 pg or 100 ng/mouse) and ginsenoside Rb1 (100 fg, 10 pg, or 1 ng/mouse) isolated from red ginseng significantly inhibited increases in skin thickness and wrinkle formation and reduced skin elasticity induced by long-term UVB irradiation. Furthermore, Lee et al [37] reported that the topical administration of a cream base containing red ginseng (percentage of ginseng saponins was about 3.3%) for 22 weeks resulted in significantly decreased wrinkling scores, minimal epidermal hyperplasia, slightly increased dermal cellularity, and a lack of cyst proliferation by UV-irradiation.…”

Section: Discussionmentioning

confidence: 99%

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

Lee¹,

Lee²,

Cho³

et al. 2010

Journal of Ginseng Research

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Section: Discussionmentioning

confidence: 99%

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

Lee¹,

Lee²,

Cho³

et al. 2010

Journal of Ginseng Research

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“…Recently, RG was studied for cosmetic applications and as a cosmeceutical ingredient. [13][14][15]41,42 Some researchers have studied the fermentation of RG as a way to improve its biological activity. 43,44 Bae et al 43 reported that orally administered RG extract did not significantly protect against ischemicareperfusion brain injury, whereas fermented RG did.…”

Section: Discussionmentioning

confidence: 99%

“…Ginsenosides can induce antioxidant enzymes, such as superoxide dismutase and catalase, which are important for maintaining cell viability. 11 Many previous studies have reported that P. ginseng has anti-wrinkle effects, 12 protects against ultraviolet radiation-induced skin aging, 13,14 and has anti-melanogenesis effects. 15 Furthermore, it was reported that ginseng has immunostimulating activity.…”

Section: Introduction Gmentioning

confidence: 99%

Fermenting Red Ginseng Enhances Its Safety and Efficacy as a Novel Skin Care Anti-Aging Ingredient: In Vitro and Animal Study

Lee

Kim

Park

et al. 2012

Journal of Medicinal Food

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The objective of this study was to evaluate the anti-aging potential and skin safety of red ginseng (RG) and fermented red ginseng (FRG) using Lactobacillus brevis for use as cosmetic ingredients. Concentrations of uronic acid, polyphenols, and flavonoids, and antioxidant activities were greater in FRG compared to RG. The contents of total ginsenosides were not significantly different. However, the ginsenoside metabolite content was higher in FRG (14,914.3 lg/mL) compared to RG (5697.9 lg/mL). The tyrosinase inhibitory activity (IC50) of FRG was 27.63 lg/mL, and more potent compared with RG (34.14 lg/mL), (P < .05). The elastase inhibitory activity (IC50) of FRG was 117.07 lg/mL also higher compared with RG (157.90 lg/mL). In a primary skin irritation test, 10% RG and 10% FRG were classified as practically nonirritating materials. In a skin sensitization test, the RG group showed a sensitization rate of 100% and its mean evaluation score of irritation was 1.4, whereas the FRG group showed 20% and 0.2%, respectively. By fermentation of RG, FRG has increased contents of ginsenoside metabolites, such as Rg3, Rg5, Rk1, compound K, Rh1, F2, Rg2, and flavonoids content. Therefore, FRG offers increased antiwrinkle efficacy, whitening efficacy, and reduced toxicological potency compared to RG.KEY WORDS: cosmeceutical fermented red ginseng red ginseng skin safety

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“…Therefore, 1 lg extract or 6 lg vitamin C was applied daily per mouse. Vitamin C was used as a positive control because sodium ascorbate at a concentration of 3 g/100 mL has been demonstrated to prevent UVB-induced skin damage (Kim et al 2009). The dose of the extract was selected based on the results from a previous report indicating biological activity in animal models given this dose (Jayasree et al 2013).…”

Section: Protection Of Skin Ageing Mice Against Uvbmentioning

confidence: 99%

Ethanol extract ofTerminalia chebulafruit protects against UVB-induced skin damage

Yakaew

Itsarasook

Ngoenkam

et al. 2016

Pharmaceutical Biology

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Context: The fruit of Terminalia chebula Retz. (Combretaceae) has been used for several therapeutic purposes in Thai folk medicines. Currently, the ethanol extracts containing antioxidant compounds have shown the ability to promote collagen synthesis.Objective: This purpose of this work was to study the effects of the ethanol extract from T. chebula fruit on the inhibition of cutaneous photodamage. Materials and methods: The viability of human skin fibroblasts after incubation with T. chebula at concentration 0.5-50 lg/mL for 24, 48 and 72 h was assessed by using sodium 3 0 -[(phenyl-amino)-carbonyl]-3,4,tetrazolium-bis(4-methoxy-6-notro)benzene-sulphonic acid hydrate (XTT). The levels of type I procollagen and matrix metalloproteinases (MMP)-1 and MMP-13 produced by UVB-irradiated fibroblasts were determined by ELISA. Skin thickness and collagen content caused by long-term UVB irradiation in male ICR mice were determined from haematoxylin and eosin stained tissue sections and spectrophotometric measurement of hydroxyproline. Results: The extract (0.5-50 lg/mL) had no effect on cell viability or morphology of the human fibroblasts. In vitro studies showed that the T. chebula extract reduced the UVB-induced MMP-1 and MMP-13 expression, whereas an increased production of type I procollagen was observed. In a UVB-irradiated animal model, male ICR mice with hair shaved were chronically exposed to UVB which lead to epidermal thickness and loss of hydroxyproline. However, these effects were fully prevented by the topical application of the T.

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Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice

Cited by 79 publications

References 35 publications

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

Cosmetic Potential of Enzymatic Treated Ginseng Leaf

Fermenting Red Ginseng Enhances Its Safety and Efficacy as a Novel Skin Care Anti-Aging Ingredient: In Vitro and Animal Study

Ethanol extract ofTerminalia chebulafruit protects against UVB-induced skin damage

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