Effects of glyphosate on immune responses and haemocyte DNA damage of Chinese mitten crab, Eriocheir sinensis

Hong, Yuhang; Yang, Xiaozhen; Yan, Guangwen; Huang, Yi; Zuo, Fang; Shen, Yixue; Ding, Yan; Cheng, Yongxu

doi:10.1016/j.fsi.2017.09.062

Cited by 78 publications

(31 citation statements)

References 33 publications

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“…Toxicity to the water flea (Daphnia magna) is of special importance, and not only formulated glyphosate-based herbicides (Cuhra et al, 2013;Ørsted and Roslev, 2015), but also glyphosate residues in GT soybean were shown to exert toxicity on this standard ecotoxicity indicator organism. Effects of glyphosate on somatic and ovarian growth, as well as of glyphosatebased formulations on ovarian growth and immune status of freshwater and estuarine crab species were reported (Hong et al, 2017;Avigliano et al, 2018;Canosa et al, 2018). Toxicities have extensively been reported for fish, including the zebrafish D. rerio, on which both glyphosate (Armiliato et al, 2014;Lopes et al, 2014;Uren Webster et al, 2014) and its formulated products (Bridi et al, 2017;Sulukan et al, 2017) were found to exert acute toxicity through inhibited carbonic anhydrase activity due to oxidative stress (production of reactive oxygen species), cellular apoptosis, effects on locomotor activity and aversive behavior, as well as reproduction disorders, deteriorating sperm quality, embryotoxicity malformations, and other endocrine disruption symptoms.…”

Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

106

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Section: Registration Of Glyphosate In the European Unionmentioning

confidence: 99%

Re-registration Challenges of Glyphosate in the European Union

Székacs

Darvas

2018

Front. Environ. Sci.

106

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“…In crustacean haemocytes, antimicrobial effector cells play an important role in regulating physiological and immunological functions by acting in both adoption of the cellular immunity and supply of the humoral immunity (Liu et al, 2009;Hong et al, 2017;Saputra et al, 2019). The THC and DHC in the circulatory system of crustaceans may be easily affected by intrinsic factors and extrinsic factors including heavy metals, pathogens and pesticides (Cheng and Chen, 2000;Yao et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Fermented Animal Source Protein as Substitution of Fishmeal on Intestinal Microbiota, Immune-Related Cytokines and Resistance to Vibrio mimicus in Freshwater Crayfish (Cherax cainii)

et al. 2020

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A feeding trial was carried out to evaluate the effects of substitution of fishmeal (FM) by dietary poultry by-product meal, fermented by Lactobacillus casei and Saccharomyces cerevisiae on growth, intestinal health, microbial composition, immune related cytokines and disease resistance of freshwater crayfish, marron (Cherax cainii) against Vibrio mimicus. Two isonitrogenous and isocaloric diets were formulated by replacing FM protein with fermented poultry by-product meal (FPBM) protein at 0% (Control) and 75% (FPBM), and fed marron for 70 days. The results indicated no significant difference (P > 0.05) in final body weights between two groups of marron, whilst intestinal microvilli number per fold was increased in marron fed FPBM than the control. The 16S rRNA sequences revealed an increased number of Lactobacillus and Streptococcus, and decreased number of Aeromonas at genus level in the distal intestine of marron fed FPBM. Marron fed FPBM showed up-regulated expression of IL-8, IL-10, and IL-17F genes in the distal intestine. Significantly (P < 0.05) increased lysozyme and phagocytic activity, and higher survival was found in marron fed FPBM following a bacterial challenge with Vibrio mimicus. Therefore, it is concluded that FPBM is beneficial to marron in terms of microbial community, immune-related cytokines and disease resistance against V. mimicus.

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“…Nevertheless, the observed effects in the second experiment may be due to an effect of glyphosate on mosquito immunity. Glyphosate can affect invertebrate immunity in several ways, including effects on hemocyte parameters (Hong, Yang, Huang, Yan, & Cheng, 2018; Hong et al, 2017; Matozzo et al, 2019; Monte et al, 2019), activity of immune enzymes (Hong et al, 2017), and on oxidative stress (de Melo Tarouco et al, 2017; Pala, 2019). The effects on invertebrate immunity were generally negative.…”

Section: Discussionmentioning

confidence: 99%

Impact of field‐realistic doses of glyphosate and nutritional stress on mosquito life history traits and susceptibility to malaria parasite infection

Bataillard

Christe

Pigeault

2020

Ecology and Evolution

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Glyphosate is the world's most widely used herbicide. The commercial success of this molecule is due to its nonselectivity and its action, which would supposedly target specific biosynthetic pathways found mainly in plants. Multiple studies have however provided evidence for high sensitivity of many nontarget species to glyphosate and/or to formulations (glyphosate mixed with surfactants). This herbicide, found at significant levels in aquatic systems through surface runoffs, impacts life history traits and immune parameters of several aquatic invertebrates' species, including disease‐vector mosquitoes. Mosquitoes, from hatching to emergence, are exposed to aquatic chemical contaminants. In this study, we first compared the toxicity of pure glyphosate to the toxicity of glyphosate‐based formulations for the main vector of avian malaria in Europe, Culex pipiens mosquito. Then we evaluated, for the first time, how field‐realistic dose of glyphosate interacts with larval nutritional stress to alter mosquito life history traits and susceptibility to avian malaria parasite infection. Our results show that exposure of larvae to field‐realistic doses of glyphosate, pure or in formulation, did not affect larval survival rate, adult size, and female fecundity. One of our two experimental blocks showed, however, that exposure to glyphosate decreased development time and reduced mosquito infection probability by malaria parasite. Interestingly, the effect on malaria infection was lost when the larvae were also subjected to a nutritional stress, probably due to a lower ingestion of glyphosate.

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Effects of glyphosate on immune responses and haemocyte DNA damage of Chinese mitten crab, Eriocheir sinensis

Cited by 78 publications

References 33 publications

Re-registration Challenges of Glyphosate in the European Union

Re-registration Challenges of Glyphosate in the European Union

Fermented Animal Source Protein as Substitution of Fishmeal on Intestinal Microbiota, Immune-Related Cytokines and Resistance to Vibrio mimicus in Freshwater Crayfish (Cherax cainii)

Impact of field‐realistic doses of glyphosate and nutritional stress on mosquito life history traits and susceptibility to malaria parasite infection

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