Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats

Belviranlı, Muaz; Gökbel, Hakkı; Okudan, Nilsel; Başaralı, Kemal

doi:10.1017/s0007114511005496

Cited by 40 publications

(35 citation statements)

References 54 publications

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“…Results of our study suggest that Ex may enhance lipid peroxidation and reduce the oxidative damage of proteins and DNA 23. Reduced oxidative stress results from an enhanced antioxidant defense system 24,25. Chronic Ex reduces oxidative stress by upregulating the activity of antioxidant enzymes 26.…”

Section: Discussionmentioning

confidence: 78%

“…Chronic Ex reduces oxidative stress by upregulating the activity of antioxidant enzymes 26. Belviranli et al25 have reported that plasma MDA levels were lowered in chronically exercised groups compared to controls, as well as by an antioxidant (grape seed extract) supplementation. They also reported the plasma activities of SOD, an antioxidant defense for superoxide radicals that catalyzes the dismutation of superoxide and the formation of H 2 O 2 and GPx.…”

Section: Discussionmentioning

confidence: 99%

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Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model

Şahin¹,

Pala²,

Tuzcu

et al. 2016

JIR

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PurposeExercise (Ex) increases reactive oxygen species and impairs antioxidant defense systems. Recent data suggest that curcumin (CW) possesses peroxisome proliferator-activated receptor gamma activity and anti-inflammatory properties. Therefore, this study was designed to investigate the effects of CW supplementation on Ex performance, endurance, and changes in serum and muscle proteins in rats after exhaustive Ex.Materials and methodsTwenty-eight (28) male Wistar rats (age: 8 weeks and body weight: 180±20 g) were divided into four treatment groups: 1) control (C; no Ex), 2) C + CW (no Ex + CW), 3) C + Ex, and 4) C + Ex + CW (Ex + CW). CW was administered as 100 mg/kg CurcuWin®, providing 20 mg of curcuminoids daily for 6 weeks. A motor-driven rodent treadmill was used to carry out the Ex protocols. During a 5-day period, animals in chronic Ex groups were put through different regimens: day 1, 10 m/min for 10 minutes; day 2, 20 m/min for 10 minutes; day 3, 25 m/min for 10 minutes; day 4, 25 m/min for 20 minutes; and day 5, 25 m/min for 30 minutes. Animals were exercised at 25 m/min for 45 min/d for 5 d/wk for 6 weeks. Blood and muscle samples were analyzed for muscle markers, oxidative stress, and antioxidant markers.ResultsLactate and muscle malondialdehyde levels decreased in the CW-treated groups (P<0.0001). However, activities of antioxidant enzyme levels increased in the CW-treated groups. Run to exhaustion (minutes) improved in the CW-treated groups. Muscle nuclear factor-κB (P<0.05) and heat shock protein 70 (P<0.05) levels were much lowered in the CW treated group followed by Ex group. In addition, muscle inhibitors of kappa B, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, thioredoxin-1, sirtuin 1, nuclear factor (erythroid-derived 2)-like 2, and glucose transporter 4 protein levels in the Ex + CW group were higher than those in the control and Ex groups (P<0.05).ConclusionThis study suggests that novel CW has the potential to help prevent muscle damage by regulating the nuclear factor-κB and nuclear factor (erythroid-derived 2)-like 2 pathways and improve the performance and nutritional values of CW.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model

Şahin¹,

Pala²,

Tuzcu

et al. 2016

JIR

View full text Add to dashboard Cite

show abstract

“…There was no difference for the amount of water and diet consumed among these groups. Similar dosages of GSE have been used in previous studies [22,23]. GSE used in this study is a commercial GSE product (Gravinol-S) purchased from OptiPure Chemco Industries Inc. (Los Angeles, CA).…”

Section: Methodsmentioning

confidence: 99%

Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice

Wang

Yang

Liang

et al. 2014

BMC Complement Altern Med

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BackgroundMuscle wasting is frequently a result of cancers, AIDS, chronic diseases and aging, which often links to muscle inflammation. Although grape seed extract (GSE) has been widely used as a human dietary supplement for health promotion and disease prevention primarily due to its anti-oxidative and anti-inflammative effects, it is unknown whether GSE affects muscle wasting. The objective is to test the effects of GSE supplementation on inflammation and muscle wasting in interleukin (IL)-10 knockout mice, a recently developed model for human frailty.MethodsMale IL-10 knockout (IL10KO) C57BL/6 mice at 6 weeks of age were assigned to either 0% or 0.1% GSE (in drinking water) groups (n = 10) for 12 weeks, when skeletal muscle was sampled for analyses. Wild-type C57BL/6 male mice were used as controls.ResultsTibialis anterior muscle weight and fiber size of IL10KO mice were much lower than wild-type mice. IL10KO enhanced nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling and inflammasome formation when compared to wild-type mice. Phosphorylation of anabolic signaling was inhibited, whereas muscle specific ubiquitin ligase, AMP-activated protein kinase (AMPK) and apoptotic signaling were up-regulated in IL10KO mice. GSE supplementation effectively rectified these adverse changes in IL10KO muscle, which provide an explanation for the enhanced muscle mass, reduced protein degradation and apoptosis in GSE supplemented mice compared to IL10KO mice without supplementation.ConclusionGSE supplementation effectively prevents muscle wasting in IL10KO mice, showing that GSE can be used as an auxiliary treatment for muscle loss associated with chronic inflammation and frailty.

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“…Parallel to the studies on the benefi cial effects of exercise and its effects on oxidative stress investigations on the effects of dietary supplementation with antioxidants have been carried out by a number of authors. In the recent years special attention has been focused on the effects of ingested free radical scavenging polyphenols present in grapes [11,12], rose-hips [13,14], blueberries [15,16], and pomegranates [17][18][19] on oxidative stress markers in animals and humans. The major bioactive compounds within these fruits are besides polyphenols, ascorbic acid, tocopherol, lycopene, tannins, ß carotene, sugars, amino acids, and essential fatty acids [20].…”

Section: Introductionmentioning

confidence: 99%

Effects Of Rose-Hip And Grapeseed Dietary Supplementation On Serum Oxidative Stress Parameters In Dogs Before And After Physical Exercise

Kukovska¹,

Celeska

Ruskovska

et al. 2015

Acta Veterinaria

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The aim of this study was to evaluate the effects of 60 days of rose-hip and grapeseed dietary supplementation of a balanced home-cooked diet on serum oxidative stress parameters: ROMs, MDA and FRAP in army service dogs before and after regular physical exercise. The dogs were fed a balanced cooked diet as instructed by army standards until the initial blood sampling in June. Thereon the dogs were randomly allotted to 4 groups according to the dietary regime: dogs maintained on a balanced cooked diet according to army standards, branded dry dog food, cooked diet with added 500 mg rose-hip extract, and cooked diet with added 100 mg grapeseed extract for a 60 day period from June to September after which all 4 groups were fed the standard cooked meal diet. Sampling was performed at the beginning of the experiment (June), 60 days from the start of the treatment (September) and finally 60 days after the end of supplementation (November). Statistical analysis of the results included descriptive statistical parameters: mean (M), standard deviation (SD), and variation coefficient (CV%). In order to test the statistical significance of the differences between treatments a multifactor variance test (ANOVA) was performed for ROM, MDA and FRAP and the combined effects of diet, exercise and time period were observed. The initial (in June) increase in MDA and ROMs after exercise indicates the presence of oxidative stress 30 minutes after exercise. However, the antioxidative effects of rose-hip and grapeseed extracts are not conclusive, as multifactor ANOVA testing of time, diet, and exercise factors did not reveal for MDA statistically significant differences either at 60 days of supplementation nor 60 days after withdrawal of the supplements. Only one distinct exception was recorded for the prolonged antioxidative effects reflected in significantly decreased (p<0.01) ROMs before and after exercise in dogs fed the branded dry food 60 days after the end of such dietary regime (November). FRAP values tend to be higher (p>0.05) after exercise compared to before exercise in all experimental groups in November, indicating on a possible redistribution and upregulation of endogenous antioxidants during the experiment.

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Effects of grape seed extract supplementation on exercise-induced oxidative stress in rats

Cited by 40 publications

References 54 publications

Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model

Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model

Grape seed extract prevents skeletal muscle wasting in interleukin 10 knockout mice

Effects Of Rose-Hip And Grapeseed Dietary Supplementation On Serum Oxidative Stress Parameters In Dogs Before And After Physical Exercise

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