Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

Çetin, Aysun; Arslanbaş, Umit; Saraymen, Berkay; Canöz, Özlem; Öztürk, Ahmet; Sağdıç, Osman

doi:10.4999/uhod.10060

Cited by 18 publications

(11 citation statements)

References 36 publications

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“…However, the CP + Propolis and CP + NP application significantly changed this difference in a positive way ( Table 2 ). In a study conducted on rats with liver damage induced by CP, Cetin et al [ 50 ] investigated the effects of grape seed and essential thyme oil on some serum blood parameters. They determined that CP caused a statistically significant increase in serum ALT and AST levels.…”

Section: Discussionmentioning

confidence: 99%

“…Caffeic acid phenethyl ester (CAPE), one of the main ingredients of propolis, blocks the production of ROS [ 60 ]. The results of previous studies reported that CP caused damage in the liver tissue by increasing the MDA level and decreasing antioxidant enzymes; however, antioxidant contributions minimized that damage [ 50 , 61 ]. In a study using grape seed extract to determine whether or not especially effective phenolic compounds could reduce liver damage [ 50 ], it was found that superoxide dismutase and GSPx activities in the liver tissue were significantly higher in the CP + grape seed extract group compared to the CP alone.…”

Section: Discussionmentioning

confidence: 99%

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Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Seven

Karakuş

et al. 2020

Plants

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This study was performed to determine the effects of chitosan-coated nano-propolis (NP), which is synthesized via a green sonochemical method, and propolis on the side effects of cisplatin (CP), which is a widely used drug in the treatment of cancer. For this aim, 56 rats were divided into seven groups, balancing their body weights (BW). The study was designed as Control, CP (3 mg/kg BW at single dose of CP as intraperitoneal, ip), Propolis (100 mg/kg BW per day of propolis by gavage), NP-10 (10 mg/kg BW of NP per day by gavage), CP + Propolis (3 mg/kg BW of CP and 100 mg/kg BW of propolis), CP + NP-10 (3 mg/kg CP and 10 mg/kg BW of NP), and CP + NP-30 (3 mg/kg BW of CP and 30 mg/kg BW of NP). Propolis and NP (especially NP-30) were preserved via biochemical parameters, oxidative stress, and activation of apoptotic pathways (anti-apoptotic protein: Bcl-2 and pro-apoptotic protein: Bax) in liver and kidney tissues in the toxicity induced by CP. The NP were more effective than propolis at a dose of 30 mg/kg BW and had the potential to ameliorate CP’s negative effects while overcoming serious side effects such as liver and kidney damage.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Seven

Karakuş

et al. 2020

Plants

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“…According to Opitz Peñuelas and Llusiá (2002) stated that temperature increases the emission and production rates of most terpenes and can replace photorespiration of the plant in protection from photodamage by scavenging oxygen-reactive species; likely explaining our observations in this study. Abdelhafiz et al (2014), Cetin et al (2011) and Dkhil et al (2013) and stated that using a plant-derived-material can protect against cisplatin-induced hepatotoxicity. P. minus is one of those candidate plants due to high level of FIGURE 5.…”

Section: Discussionmentioning

confidence: 99%

“…El-Sayyad et al (2009) and Kart et al (2010) showed that cisplatin induced severe anomalies in liver tissue histology and the ultrastructure. Whilst the mechanisms underlying cisplatin-induced hepatoxicity remains poorly understood, oxidative stress is thought to primarily mediate cisplatininduced hepatotoxicity (Cetin et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Preventive Effects of Polygonum minus Essential Oil on Cisplatin-Induced Hepatotoxicity in Sprague Dawley Rats

Rashid

Hussan

Hamid³

et al. 2019

JSM

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Cisplatin is a chemotherapeutic agent widely used in treating various types of cancer. However, its usage is restricted due to the adverse hepatoxicity, as seen in approximately 36% of cancer patients receiving cisplatin treatment. Polygonum minus essential oil has high antioxidant capacity, and is enriched with terpenoids and phenolic compounds. The objective of this study was to investigate effects of P. minus essential oil (PmEO) supplementation on cisplatininduced hepatotoxicity in rats. Male rats were divided into seven different groups, namely: control (C), cisplatininduced (CP), positive control with β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg (PmEO100CP), PmEO 200 mg/kg (PmEO200CP), PmEO 400 mg/kg (PmEO400CP) and PmEO 400 mg/kg alone (PmEO400). PmEO and BCP was given orally for 14 days prior to a single dose cisplatin (10 mg/kg) injection on day 15 and rats were sacrificed on day 18. Liver enzymes, histology, ultrastructural morphology and oxidative stress markers such as glutathione, glutathione peroxidase, catalase, superoxide dismutase and malondialdehyde were assayed. Compared to controls, levels of transaminase enzymes, serum bilirubin and oxidative stress were all increased in CP, PmEO200CP and PmEO400CP groups. However, only PmEO100CP and BCP groups reduced these increases in level of transaminase enzymes and oxidative stress compared to CP group. On both light microscopic and ultrastructural examination, CP and PmEO400CP groups showed hepatotoxicity, exhibited by cytoplasmic vacuolation, congested blood sinusoids and increased number of Kupffer cells. However, these changes were minimized in the PmEO100CP group. Therefore, we concluded that PmEO given at 100 mg/kg has preventive effect against cisplatin-induced hepatotoxicity in rats. ABSTRAKCisplatin adalah agen kemoterapi yang digunakan secara meluas untuk merawat pelbagai jenis kanser. Walau bagaimanapun, penggunaannya adalah sangat terhad disebabkan oleh berlakunya kehepatoksikan dalam kalangan kira-kira 36% pesakit kanser yang menerima rawatan cisplatin. Minyak pati Polygonum minus mempunyai keupayaan antioksidan yang tinggi dan diperkaya dengan terpenoid dan sebatian fenolik. Objektif kajian ini adalah untuk mengkaji kesan suplemen minyak pati P. minus (PmEO) ke atas cisplatin-aruhan kehepatoksikan di dalam tikus. Tikus jantan dibahagikan kepada tujuh kumpulan yang berbeza iaitu: kawalan (C), cisplatin-aruhan (CP), kawalan positif dengan β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg (PmEO100CP), PmEO 200 mg/kg (PmEO200CP), PmEO 400 mg/kg (PmEO400CP) dan PmEO 400 mg/kg sahaja (PmEO400). PmEO dan BCP diberikan secara oral selama 14 hari sebelum dos tunggal cisplatin (10 mg/kg) disuntik pada hari ke 15 dan tikus dikorbankan pada hari ke 18. Enzim hati, histologi, morfologi ultrastruktur dan penunjuk tekanan oksidatif seperti glutation, glutation peroksida, katalase, superoksida dismutase dan malondialdehid diasai. Berbanding dengan kawalan, tahap enzim transaminase, serum bilirubin dan tekanan oksidatif semuanya meningkat dalam kumpulan ...

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“…Some endemic Origanum species including O. acutidens are used as herbal teas in the regions where they grow (Tumen et al, 1995). In addition, Origanum species are widely used as culinary herbs, in alcoholic beverages and to flavor food products (Aligiannis et al, 2001;Bendahou et al, 2009;Cetin et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Areas of Utilization of Orıganum acutidens (HAND.-MAZZ.) Ietswaart and Carvacrol

Karagöz¹,

Karagöz²

2019

Int.J.Curr.Res.Aca.Rev.

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Article InfoOriganum acutidens (Hand.-Mazz.) Ietswaart is an endemic plant growing in the eastern part of Turkey. Origanum acutidens, rich in rosmarinic acid, has a high antioxidant effect. The essential oil of this plant is rich in carvacrol. The plant has chemotypes containing up to 90% carvacrol. Carvacrol also has a comprehensive range of uses from health to food. According to results obtained from previous studies, carvacrol has a lethal effect against some cancer cells. Furthermore, carvacrol has antifungal and antibacterial effects and it is lethal for some agriculturally harmful insect species. In this study, we have compiled the details of various research findings related to the morphology, natural distribution and synonymous of Origanum acutidens, its karyological and histological features, its content and yield of essential oil and its pharmacological property and the effects of carvacrol based on an exhaustive literature review. Such knowledge could contribute to the design of new and more effective technologies for the increased use and in the number of plant-based drugs for plant and human health. Using alternative and integrative strategies such as phytochemicals against harmful insect families, bacteria and fungi in agricultural areas and storage conditions are among current necessities. In addition, this review may contribute to provide a new and additional perspective on cancer treatment by combining the finding that the carvacrol in the essential oil of Origanum acutidensis effective against cancer cells.

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Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

Cited by 18 publications

References 36 publications

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Preventive Effects of Polygonum minus Essential Oil on Cisplatin-Induced Hepatotoxicity in Sprague Dawley Rats

Areas of Utilization of Orıganum acutidens (HAND.-MAZZ.) Ietswaart and Carvacrol

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