Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia reperfusion in mice

Wang, Zhishun; Zhou, Haihong; Han, Qianqian; Guo, Yonglian; Li, Zhongyuan

doi:10.1590/s0102-865020200080000002

Cited by 6 publications

(6 citation statements)

References 37 publications

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“…These changes may be attributed to increased blood creatinine, urea, and uric acid clearance into the urine. These outcomes are consistent with GSE actions in different models of kidney damage, including renal ischemia-reperfusion, 53 cadmium, 54 arsenic, 55 cisplatin, 30 and induced renal injuries. Kidney injury molecule-1 (Kim-1) is a type 1 transmembrane glycoprotein, and its expression is significantly increased in proximal tubule epithelial cells following renal injury, 56 whereas NGAL is widely used to reveal the early renal tubular injury and dysfunction in kidney disease.…”

Section: Discussionsupporting

confidence: 83%

“…The hyperoxaluric rats exhibited a deficiency in GSH content, which was related to the reduction in GSH-synthesizing enzyme activities, glutathione reductase, and glucose 6-phosphate dehydrogenase. 18, 60 On the other hand, GSE exhibited remarkable antioxidant activity in different non-renal models, for instance, type-1 diabetes, 61 titanium dioxide nanoparticle-induced hepatotoxicity, 28 and D-galactose-induced ageing mouse model, 62 and in diverse renal models including renal ischemia-reperfusion, 53 carboplatin and thalidomide, 34 cisplatin, 30 and induced renal damage.…”

Section: Discussionmentioning

confidence: 99%

“…28 Furthermore, GSE showed an anti-inflammatory effect in many other models, including the monocrotaline-induced pulmonary arterial hypertension 66 and D-galactose-induced ageing. 62 As for renal action, GSE demonstrated reno-protective activity via attenuating inflammation in diverse renal models, including renal ischemia/reperfusion, 53 arsenic, 55 carboplatin, and thalidomide-induced renal injury 34 and renal fibrosis. 67 Based on the present results and previous literature, it could be suggested that GSE produces anti-inflammatory actions by affecting the canonical pathway of NF-κB activation.…”

Section: Discussionmentioning

confidence: 99%

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Grape Seed Extract and Urolithiasis: Protection Against Oxidative Stress and Inflammation

Alomair

Alobaid

Almajed

et al. 2023

Pharmacognosy Magazine

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Background Grape seed extract (GSE) has demonstrated various pharmacological actions. Urolithiasis is the occurrence of calculus in the renal system. The present study evaluated the anti-urolithic effect of GSE on ethylene glycol (EG) and ammonium chloride (AC)-induced experimental urolithiasis in rats. Materials and Methods Rats were assigned into six groups; Normal control and Normal + GSE, in which rats received standard drinking water and GSE orally daily, respectively; Urolithiatic animals received EG with AC in drinking water for 28 days; Urolithiatic animals + GSE, in which rats were administered EG with AC in drinking water and GSE 100 and 200 mg/kg orally; and Urolithiatic + cystone, where rats received EG with AC in drinking water and 750 g/kg of cystone as a standard drug orally. Results Urolithiatic animals showed a significant decrease in excreted magnesium and citrate and antioxidant enzymes, whereas they exhibited amplified oxalate crystal numbers, urinary excreted calcium, phosphate, oxalate ions, uric acid, intensified renal function parameters, lipid peroxidation, and inflammatory mediators. Management with GSE and cystone significantly augmented urolithiasis inhibitors (excreted magnesium and citrate) and amplified the antioxidant enzymes’ activities. GSE reduced oxalate crystal numbers and urolithiasis promoters, including excreted calcium, oxalate, phosphate, and uric acid excretion, lessened renal function parameters, and declined lipid peroxidation and the inflammatory mediators. Conclusion GSE could protect against EG-induced renal stones as evidenced by mitigated kidney dysfunction, histological alterations, and oxalate crystal formation. This action may be related to the antioxidant as well as anti-inflammatory activities of the extracts.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Grape Seed Extract and Urolithiasis: Protection Against Oxidative Stress and Inflammation

Alomair

Alobaid

Almajed

et al. 2023

Pharmacognosy Magazine

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“…Naringin was shown to reduce I/R-induced oxidative stress by enhancing the expression level of Nrf2 in renal tissues and preventing ECG changes and myocardial damage following renal IR injury [33]. Furthermore, proanthocyanidin pretreatment was found to enhance the expression of anti-oxidative stress proteins through the Nrf2/HO-1 signaling pathway and to significantly reduce oxidative stress damage in the kidney tissue of ICR mice during the period of renal I/R injury [34].…”

Section: Anti-oxidative Stress Injurymentioning

confidence: 99%

“…Furthermore, genistein (15 mg/kg) was shown to exert its antiapoptotic and proliferative effects via the SIRT1/p53 axis, and thus ameliorates I/R-induced renal injury [6]. Among the flavonoids, baicalin [32,55], chrysin [49], quercetin [63], fisetin [64], hesperidin [39], naringin [65], EGCG [51], proanthocyanidins [34], anthocyanins [29], and HYSA [56] Pharmacology 2023;108:27-36 DOI: 10.1159/000527262 were also demonstrated to have protective effects against renal I/R injury by inhibiting apoptosis.…”

Section: Anti-cell Deathmentioning

confidence: 99%

Protective Effects and Mechanisms of Flavonoids in Renal Ischemia-Reperfusion Injury

et al. 2022

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Background: Acute kidney injury (AKI) is a common and potentially fatal complication encountered during a variety of kidney surgeries. Renal ischemia/reperfusion (I/R) injury is the predominant mechanism of AKI in this setting. Hence, controlling I/R injury is a key research imperative as it is directly related to the prognosis of patients. Summary: In the last decade, studies in vitro and in animal models have demonstrated that flavonoids can significantly alleviate I/R-induced AKI through a variety of pathways, including anti-oxidative stress, anti-inflammation, anti-cell death, inhibition of endoplasmic reticulum stress, and alleviation of mitochondrial dysfunction. Based on the extensive role of flavonoids in ischemia-reperfusion injury, the lack of drugs entering the clinic so far is a question worthy of consideration. Key Messages: This review summarizes the available evidence pertaining to the protective effect of flavonoids against renal I/R injury and discusses their potential clinical application in renal I/R injury.

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Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia–reperfusion injury model of mice

et al. 2023

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Purpose To investigate the effect of grape seed-derived proanthocyanidin B2 (GSPB2) pretreatment on acute renal ischemia–reperfusion injury model of mice. Methods 50 mice were divided into 5 groups: Sham group: mice were treated with right nephrectomy. GSPB2 group: GSPB2 was injected intraperitoneally 45 min before right nephrectomy. IRI group: right kidney was resected and the left renal arteriovenous vessel was blocked for 45 min. GSPB2 + IRI group: GSPB2 was intraperitoneally injected 45 min before IRI established. GSPB2 + BRU + IRI group: GSPB2 and brusatol (BRU) were injected intraperitoneally 45 min before IRI established. Creatinine and urea nitrogen of mice were detected, and the kidney morphology and pathological changes of each group were detected by HE staining, PAS staining and transmission electron microscopy. Expressions of Nrf2, HO-1, GRP78, CHOP, and cleaved-caspase3 were detected by immunofluorescence staining and western blotting. Results Morphology and mitochondrial damages of kidney in GSPB2 + IRI group were significantly alleviated than those in IRI group. Expression levels of Nrf2 and HO-1 were significantly higher in GSPB2 + IRI group than those in IRI group. Expression levels of GRP78, CHOP and cleaved-caspase3 were significantly lower in GSPB2 + IRI group than those in IRI group. However, compared to GSPB2 + IRI group, protective effects of GSPB2 pretreatment were weakened in GSPB2 + BRU + IRI group. Conclusions GSPB2 pretreatment could alleviate oxidative stress damage and reduce apoptosis of renal tubular epithelial cells, which might be related to activating the antioxidant system, up-regulating the expression of Nrf2 and HO-1, inhibiting the expressions of GRP78, CHOP and cleaved-caspase3. However, the protective effect could be reversed by brusatol.

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Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia reperfusion in mice

Abstract: Design of the study, acquisition of data, supervised all phases of the study.

Cited by 6 publications

References 37 publications

Grape Seed Extract and Urolithiasis: Protection Against Oxidative Stress and Inflammation

Grape Seed Extract and Urolithiasis: Protection Against Oxidative Stress and Inflammation

Protective Effects and Mechanisms of Flavonoids in Renal Ischemia-Reperfusion Injury

Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia–reperfusion injury model of mice

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