Effects of growth hormone on initial bone formation around dental implants: a dog study

Calvo-Guirado, José Luís; Maté-Sánchez, José E.; Delgado-Ruíz, Rafael Arcesio; Ramírez-Fernández, María Piedad; Cutando-Soriano, Antonio; López-Peña, Mónica

doi:10.1111/j.1600-0501.2010.02007.x

Cited by 27 publications

(33 citation statements)

References 22 publications

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“…These results are in agreement with the authors’ previous data [11] and other authors [34]. For example, Calvo-Guirado et al [14] found topical application of 4 IU of GH like biomimetic agent at the moment of implant placement has no significant effects on the BIC at 5 and 8 weeks, although bone formation and inter-thread bone values did increase significantly. However, controversial about the efficiency of the topical administration of GH is found in the literature.…”

Section: Discussionsupporting

confidence: 92%

Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits

et al. 2016

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BackgroundIn this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed.Methods The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy.ResultsThe oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm−2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation.ConclusionsThe oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site.

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Section: Discussionsupporting

confidence: 92%

Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits

et al. 2016

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“…Nosso trabalho tem o intuito de utilizar o rhGH localmente, a partir de um dispositivo de liberação controlada, a matriz de PLGA. Assim, teremos a presença do rhGH intimamente no local da cicatrização óssea, como nos trabalhos de Calvo-Guirado et al 7 , que utilizaram o rhGH topicamente ao redor do implante em mandíbula de cães, bem como no trabalho de Gómez-Moreno et al 8 e Tresguerres et al 19 . Todos tiveram como resultados uma maior atividade celular e mitótica na fase de cicatrização, acelerando o processo cicatricial, a osteointegração.…”

Section: Discussionunclassified

“…O GH é secretado principalmente à noite, durante toda a vida; porém, seu pico de secreção ocorre durante a puberdade e há um decréscimo acentuado de sua produção a partir da sexta década de vida, sendo esse hormônio também conhecido como o hormônio da velhice 6 . Estudos demostram que o uso tópico do hormônio de crescimento humano recombinante (rhGH) tem acelerado o processo de osteointegração, estimulando a osteogênese e também acelerando o processo de remodelação óssea e maturação em volta dos implantes 7 . Gomez-Moreno et al 8 11,12 .…”

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Incorporação do hormônio do crescimento humano recombinante (rhGH) em matriz de polímero biodegradável

Garcia

Duarte

Boing

et al. 2015

Rev. odontol. UNESP

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ResumoObjetivo: Incorporar o hormônio de crescimento recombinante humano em um polímero biodegradável (PLGA). Material e método: As matrizes foram confeccionadas através da técnica de evaporação de solventes. Foi feita uma mistura do polímero (poli ácido glicólico lático) e do hormônio do crescimento humano recombinante (Saizen  Merck Serono S.A. Aubonne, Suíça). Essa mistura foi vertida em moldes de silicone circulares de 1 cm de diâmetro e aproximadamente 2 mm de espessura, e levada para secagem em uma câmara de evaporação de solvente por 48 horas. Após esse período, as matrizes foram imersas em PBS e passaram por um banho termostatizado (ensaio de degradação hidrolítica), in vitro, à temperatura de 37°C. As amostras foram retiradas do banho no intervalo de 1, 2, 3, 4, 7, 10 e 14 dias. Foram aferidas a perda de massa, a variação do pH e a concentração do hormônio liberado em função do tempo. Resultado: A concentração do hormônio liberado em função do tempo foi aumentando até o terceiro dia. No quarto dia, houve uma queda e, no sétimo, ocorreu um aumento do hormônio liberado, estendendo-se até o décimo dia; no 14° dia, houve queda novamente. O pH teve uma queda brusca de 7,4 para 3,2 no primeiro dia, mantendo uma pequena queda até o 14° dia. A perda de massa foi gradual em relação ao tempo, como já era esperado. Conclusão: O PLGA é um bom biomaterial para confecção de matrizes com hormônio do crescimento. Revelou-se possível incorporar o rhGH nessa matriz, de modo a, então, desenvolver-se um substituto ósseo.Descritores: Polímeros; hormônio do crescimento; biodegradação. AbstractObjective: Incorporate recombinant human growth hormone in a biodegradable polymer (PLGA). Material and method: The arrays were fabricated by solvent evaporation technique. A mixture of polymer (poly lactic glycolic acid) and recombinant human growth (Saizen  Merck Serono SA Aubonne, Switzerland) was performed hormone. This mixture was poured into circular molds silicone 01cm in diameter and about 02mm thick, and carried into a drying chamber for evaporation of solvent for 48 hours. After this period, the matrices were immersed in PBS and passed through a constant temperature bath (test for hydrolytic degradation) in vitro, at a temperature of 37°C. The samples were removed from the bath in the range of 01, 02, 03, 04, 07, 10, 14 days. Mass loss, pH and concentration of hormone released as a function of time was measured. Result: The concentration of hormone released versus time was increased until the third day. On the fourth day had a fall and on the seventh day there have been increased hormone released by the tenth day, the fourteenth day was falling again. The pH had a sharp drop from 7.4 to 3.2 on the first day and keeping a small drop until the fourteenth day. The mass loss was a gradual loss in relation to time as was to be expected. Conclusion: PLGA is a good biomaterial for making breeders of growth hormone. It has proved possible to incorporate the rhGH in the array so as to then develop a bone substitute.Descriptors: Polym...

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“…It directly increases longitudinal bone growth by stimulating prechondrocites. GH is a polypeptide complex that regulates the processes of bone physiology, increases the rate of mitosis of chondrocytes and osteoblasts, and increases the rate of protein synthesis (collagen, cartilage matrix, and enzymes for cartilage and bone formation) (Ohlsson et al 1998;Calvo-Guirado et al 2011). -Insulin -increases energy production from glucose.…”

Section: Bone Regenerationmentioning

confidence: 99%

Biomaterials Applicable for Alveolar Sockets Preservation: In Vivo and In Vitro Studies

Kunert‐Keil¹,

Gredes²,

Gedrange³

2011

Implant Dentistry - The Most Promising Discipline of Dentistry

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Effects of growth hormone on initial bone formation around dental implants: a dog study

Abstract: Topical application of 4 IU of GH like a biomimetic agent at the moment of implant placement has no significant effects on the BIC at 5 and 8 weeks, although bone neoformation and inter-thread bone values did increase significantly.

Cited by 27 publications

References 22 publications

Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits

Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits

Incorporação do hormônio do crescimento humano recombinante (rhGH) em matriz de polímero biodegradável

Biomaterials Applicable for Alveolar Sockets Preservation: In Vivo and In Vitro Studies

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