Osseointegration of TI6Al4V dental implants modified by thermal oxidation in osteoporotic rabbits

Abstract

BackgroundIn this work, the effect of the heat treatment on Ti6Al4V implants and topical administration of growth hormone to address a better osseointegration in osteoporotic patients has been analysed.Methods The osseointegration process of Ti6Al4V implants modified by oxidation treatment at 700 °C for 1 h and the influence of local administration of growth hormone (GH) in osteoporotic female rabbits after 15 and 30 days of implantation have been studied. Bone response was analysed through densitometric and histomorphometric studies. Characterization of the surface was provided by scanning electron microscopy.ResultsThe oxidation treatment promotes the formation of an oxide scale grown on the Ti6Al4V implants that alters the nanoroughness of the surface. Bone mineral density (BMD) increases from 0.347 ± 0.014 (commercial) to 0.383 ± 0.012 g cm−2 (modified), and bone-to-implant contact (BIC) goes from 48.01 ± 14.78 (commercial) to 55.37 ± 15.31 (modified) after 30 days of implantation.ConclusionsThe oxidation treatment on the Ti6Al4V dental implants enhances the early bone formation at the longest periods of implantation. No significant differences in the BMD and BIC results in healthy and osteoporotic rabbits were revealed with respect to the local administration of GH in the implantation site.

Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

“…In vitro experiments with primary osteoblast cell culture revealed that the surface modification does not alter but may improve the excellent biocompatible behaviour. In fact, cell adhesion and osteointegration are favored on the thermally treated surfaces [ 49 , 50 ].…”

Thermal oxidation and hydrofluoric acid treatment on the sandblasted implant surface: A histologic histomorphometric and biomechanical study

“…In an early study, thermal oxidation of the Ti implants at 280°C for 3 hr yielded a 1.6-to 5. machined implants (Hazan & Oron, 1993). Bodelon et al (2016) also examined the bone response of thermally oxidized implants in a rabbit model, where oxidation was executed at 700°C for were found for any of the parameters, and researchers should be aware of this incompetency, which has been previously reported (Akkocaoglu et al, 2005;Aparicio et al, 2006). However, a direct comparison of the present findings and previous reports is not feasible due to the employment of different methodologies in thermal oxidation and HF application.…”

“…Bodelon et al. () also examined the bone response of thermally oxidized implants in a rabbit model, where oxidation was executed at 700°C for 1 hr, and a final BIC% of 55.37% was achieved after 30 days of implant placement. Rough‐surfaced control implants demonstrated a BIC% of 48.01%.…”

“…The passive thin amorphous oxide layer (2-10 nm) that provided the principal features of the Ti was modified by thermal oxidation, thereby allowing growth of the oxide layer (c. 60 μm thick) with crystalline features (Guleryuz & Cimenoglu, 2004;Wen, Wen, Hodgson, & Li, 2012). Consequently, in vivo studies confirmed that thermal oxidation not only enhanced the stem cell behavior but also improved the in vivo properties of the osseointegration (Bodelon et al, 2016;Wang et al, 2016). This finding was related to the emerged submicron irregularities and deep grain boundaries of the thickened oxide layer, cultivating protein absorption and cell adhesion (Kumar, Narayanan, Raman, & Seshadri, 2010;Saldana et al, 2007;Wang et al, 2016).…”

Titanium Alloys for Dental Implants: A Review

“…Amounts released are also below the average nutritional uptake of these ions. Studies have confirmed that this alloy will undergo satisfactory osseointegration [3][4][5], especially when treated to enhance the oxide layer on the surface [10]. The design of modern implants usually involves a screw thread through which the metal alloy component becomes anchored within the bone of the mandible or maxilla.…”