Effects of High-Intensity Exercises on 13C-Nandrolone Excretion in Trained Athletes

Baume, N; Avois, L; Sottas, Pierre-Edouard; Dvořák, Jiří; Cauderay, Michel; Mangin, Patrice; Saugy, Martial

doi:10.1097/01.jsm.0000158255.78040.ec

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Contaminated supplements and endogenous production as revealed in a 13C nandrolone excretion study in trained athletes4 may, in part at least, have impacted on these positive cases. Further support for this idea emerged from a study that found traces of the metabolites of nandrolone following 90 min of football in healthy volunteers 5. This finding led to a 2 ng per mL cut-off level for nandrolone metabolites being introduced as an adverse analytical finding.…”

Section: A Historical Perspectivementioning

confidence: 99%

Challenges and threats to implementing the fight against doping in sport

2014

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Prominent doping cases in certain sports have recently raised public awareness of doping and reinforced the perception that doping is widespread. Efforts to deal with doping in sport have intensified in recent years, yet the general public believes that the 'cheaters' are ahead of the testers. Therefore, there is an urgent need to change the antidoping strategy. For example, the increase in the number of individual drug tests conducted between 2005 and 2012 was approximately 90 000 and equivalent to an increase of about 50%, yet the number of adverse analytical findings remained broadly the same. There is also a strikingly different prevalence of doping substances and methods in sports such as a 0.03% prevalence of anabolic steroids in football compared to 0.4% in the overall WADA statistics. Future efforts in the fight against doping should therefore be more heavily based on preventative strategies such as education and on the analysis of data and forensic intelligence and also on the experiences of relevant stakeholders such as the national antidoping organisations, the laboratories, athletes or team physicians and related biomedical support staff. This strategy is essential to instigate the change needed to more effectively fight doping in sport

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Section: A Historical Perspectivementioning

confidence: 99%

Challenges and threats to implementing the fight against doping in sport

2014

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“…36 The analysis of urinary metabolites by gas chromatography/combustion/isotope ratio mass spectrometry (GC/C/ IRMS) has been shown to be useful in determining their origin, endogenous or exogenous. [37][38][39][40] It is routinely used for confirmation in a few laboratories; major improvements were needed with regard to sample purification and instrumental conditions to reach the level of sensitivity required for the analysis of low levels of 19-norsteroid urinary metabolites.…”

Section: Norsteroids: Metabolism Excretion and Detection In Human Umentioning

confidence: 99%

Significance of 19-norandrosterone in athletes’ urine samples

Ayotte¹

2006

Br J Sports Med

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Nandrolone and other 19-norsteroid potent anabolic steroids have been prohibited in sports for 30 years. The detection of the main urinary metabolite--19-norandrosterone--in amounts greater than 2 ng/ml constitutes an adverse analytical finding. The presence in nutritional sport supplements of steroids not listed on the label has undoubtedly resulted in positive tests, but inadvertent consumption of meat containing residues of hormonal treatment should not realistically cause apprehension. Although highly improbable, athletes should prudently avoid meals composed of pig offal in the hours preceding the test since the consumption of edible parts of a non-castrated pig, containing 19-nortestosterone, has been shown to results in the excretion of 19-norandrosterone in the following hours. Norsteroid metabolites are formed during pregnancy and excreted as minor metabolites of norethisterone, and minute amounts have been identified in some male and female samples when using more sensitive techniques of detection. Whereas exercise does not seem to be a significant factor in 19-norandrosterone excretion, some rare urine samples were found to be a suitable medium for in situ 19-demethylation of urinary metabolites.

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“…Nandrolone is one of the most abused anabolic steroid in sports and the presence of its metabolites in urine at low concentrations is always subject to discussion, because of a possible endogenous production or intake of contaminated nutritional supplements [2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%